A Systematic Review of the Frequency of Persistent Constitutional and Respiratory Symptoms Related to COVID-19: A New Long COVID Syndrome?

Soriano-Moreno, A. N.; Soriano-Moreno, David R.; Pacheco‐Barrios, Niels; Lescano, A.

doi:10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3795

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“…Prior PCC studies presenting the prevalence of persistent symptoms following SARS-CoV-2 infection reported that constitutional symptoms are very common, which supported the high frequency of measurements. For example, the prevalence of fatigue was estimated to be 35%–45% at 4 weeks, 30%–77% at 8 weeks and 16%–55% at 12 weeks after infection and 21% more likely ≥6 months after infection 34–41. Neurological-related PCC were the next most frequently assessed PCC (measured in 83% of studies among both children and adults).…”

Section: Discussionmentioning

confidence: 99%

“…For example, the prevalence of fatigue was estimated to be 35%-45% at 4 weeks, 30%-77% at 8 weeks and 16%-55% at 12 weeks after infection and 21% Open access more likely ≥6 months after infection. [34][35][36][37][38][39][40][41] Neurologicalrelated PCC were the next most frequently assessed PCC (measured in 83% of studies among both children and adults). This finding likely reflects ongoing concerns regarding the impact of PCC-associated neurological symptoms/conditions in adults and children.…”

Section: Discussionmentioning

confidence: 99%

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Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature review

Yang,

Markus,

Andersen

et al. 2024

BMJ Open

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Post-COVID-19 conditions (PCC) is an umbrella term that encompasses a range of signs, symptoms and conditions present weeks after the acute phase of a SARS-CoV-2 infection. This systematic literature review summarises the heterogeneous methodology used to measure PCC across real-world studies and highlights trends by region, age group, PCC follow-up period and data source.MethodsMedline, EMBASE and the Cochrane Library were searched and supplemented with conference and grey literature searches. Eligible studies included individuals with (1) PCC or (2) a positive SARS-CoV-2 test or COVID-19 diagnosis who were followed over time. Included studies were published in English between 1 January 2020 and 14 November 2022.FindingsOf 291 publications included, 175 (60%) followed individuals with confirmed COVID-19 over time for PCC and 116 (40%) used a prespecified PCC definition. There was substantial heterogeneity in study design, geography, age group, PCC conditions/symptoms assessed and their classification and duration of follow-up. Among studies using a prespecified PCC definition, author-defined criteria (51%) were more common than criteria recommended by major public health organisations (19%). Measurement periods for PCC outcomes from date of acute COVID-19 test were primarily 3 to <6 months (39.2%), followed by 6 to <12 months (27.5%) and <3 months (22.9%). When classified by organ/system, constitutional-related PCC were the most frequently assessed in adult (86%) and paediatric (87%) populations. Within constitutional symptoms, fatigue was most frequently assessed in adult (91.6%) and paediatric (95.0%) populations, followed by fever/chills (37.9% and 55%, respectively).ConclusionsPCC definitions are heterogenous across real-world studies, which limits reliable comparisons between studies. However, some similarities were observed in terms of the most frequently measured PCC-associated symptoms/conditions, which may aid clinical management of patients with PCC.CRD42022376111.

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Section: Discussionmentioning

confidence: 99%