A Systematic Review of the Anti‐Inflammatory and Immunomodulatory Properties of 16 Essential Oils of Herbs

Zuo, Xu; Gu, Yinuo; Wang, Chao; Zhang, Jinrong; Zhang, Jing; Wang, Guoqiang; Wang, Fang

doi:10.1155/2020/8878927

Cited by 29 publications

(26 citation statements)

References 74 publications

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“…Otherwise, iNOSas selected multiple top compounds able to bind favorably both in COX-1 and iNOScs, suggesting possible multi-front anti-inflammatory compounds. Between these, stand out compounds as caryophyllene and patchoulene (respective compounds 4 and 6 in Figure 4 ), already with substantially reported anti-inflammatory activities [ 25 , 26 , 27 , 28 , 29 ]. Similarly, a set of monoterpenes and oxygenated compounds were recovered as top hits for iNOS by binding to both sites, the active and the cofactor one.…”

Section: Resultsmentioning

confidence: 99%

“…This set of attributes means these plant extracts have been used in natural medicine and in various technological and biotechnological applications since ancient times [ 19 , 20 , 21 , 22 , 23 , 24 ]. Of the different biological activities reported for EOs in humans, anti-inflammatory properties appear with a prominent role, presenting potential for a less invasive aid to more orthodox drugs against classical and current illnesses (such as COVID-19) [ 25 , 26 , 27 , 28 , 29 ]. For the above reasons, the development of an inexpensive, environmentally safe and sufficiently accurate method to profile the molecular content and its relative variances of the EOs from M. urundeuva seeds and a first approach to obtain insights about such activity are both valuable goals.…”

Section: Introductionmentioning

confidence: 99%

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Profile of Myracrodruon urundeuva Volatile Compounds Ease of Extraction and Biodegradability and In Silico Evaluation of Their Interactions with COX-1 and iNOS

et al. 2022

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Myracrodruon urundeuva Fr. Allem. (Anacardiaceae) is a tree popularly known as the “aroeira-do-sertão”, native to the caatinga and cerrado biomes, with a natural dispersion ranging from the Northeast, Midwest, to Southeast Brazil. Its wood is highly valued and overexploited, due to its characteristics such as durability and resistance to decaying. The diversity of chemical constituents in aroeira seed has shown biological properties against microorganisms and helminths. As such, this work aimed to identify the profile of volatile compounds present in aroeira seeds. Headspace solid phase microextraction was employed (HS-SPME) using semi-polar polydimethylsiloxane-divinylbenzene fiber (PDMS/DVB) for the extraction of VOCs. 22 volatile organic compounds were identified: nine monoterpenes and eight sesquiterpenes, in addition to six compounds belonging to different chemical classes such as fatty acids, terpenoids, salicylates and others. Those that stood out were p-mentha-1,4, 4(8)-diene, 3-carene (found in all samples), caryophyllene and cis-geranylacetone. A virtual docking analysis suggested that around 65% of the VOCs molar content from the aroeiras seeds present moderate a strong ability to bind to cyclooxygenase I (COX-I) active site, oxide nitric synthase (iNOS) active site (iNOSas) or to iNOS cofactor site (iNOScs), corroborating an anti-inflamatory potential. A pharmacophoric descriptor analysis allowed to infer the more determinant characteristics of these compounds’ conferring affinity to each site. Taken together, our results illustrate the high applicability for the integrated use of SPME, in silico virtual screening and chemoinformatics tools at the profiling of the biotechnological and pharmaceutical potential of natural sources.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Profile of Myracrodruon urundeuva Volatile Compounds Ease of Extraction and Biodegradability and In Silico Evaluation of Their Interactions with COX-1 and iNOS

et al. 2022

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“…However, loss of regulation occurs not infrequently, leading perhaps to more danger than that which triggered it. It can lead to the development of chronic disease such as asthma, atherosclerosis, inflammatory bowel disease, cardiovascular diseases, neurological disorders, and cancer [ 138 , 139 ]. Inflammation is usually classified into two categories according to its time course and intensity: acute inflammation and chronic inflammation.…”

Section: Essential Oils To Reduce Inflammation and Painmentioning

confidence: 99%

Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review

Matera¹,

Lucchi²,

Valgimigli

2023

Molecules

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Essential oils (EOs) are mixtures of volatile molecules endowed with health-promoting biological activities that go beyond their role as aromas and natural preservatives and can be exploited to develop functional foods and diet supplements. Their composition is briefly addressed along with regulatory aspects. The potential health benefit of human diet supplementation with EOs is outlined through a review of the recent literature on available clinical trials and preclinical research concerning EOs activity towards: (1) irritable bowel syndrome; (2) inflammatory bowel disease; (3) regulation of microbiota; (4) gastroprotection; (5) hepatoprotection; (6) protection of the urinary tract and diuresis; (7) management of metabolic disorders including hyperglycemia and hyperlipidemia; (8) anti-inflammatory and pain control; (9) immunomodulation and protection from influenza; and (10) neuroprotection and modulation of mood and cognitive performance. The emerging potential in such activities of selected EOs is given focus, particularly green and black cumin, bergamot, orange, myrtle, peppermint, sage, eucalyptus, lavender, thyme, lemon balm, ginger, and garlic.

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“…These include carvacrol, 1,8-cineole, cinnamaldehyde, citronellol, eugenol, geraniol, limonene, linalool, ⍺-pinene, ⍺-terpinene and terpinen-4-ol [6]. Essential oil compounds including ⍺-pinene, ⍺-terpineol, cinnamaldehyde and limonene demonstrate anti-inflammatory activity inhibiting various signal pathways and reducing production of inflammatory cytokines [11].…”

Section: Biological Activities Of Essential Oil Componentsmentioning

confidence: 99%

A Science Review of Selected Essential Oils and their Botanical Ingredients. Focus on Essential Oils used for Respiratory and Calming Indications

2021

Arch Environ Sci Environ Toxicol

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Interest in botanical ingredients is rapidly growing. Essential oils are a key part of this growth and are one of the most important natural products derived from plants. Rising prevalence of both mental and physical health issues is contributing to this increased demand. Essential oils have been used traditionally for millennia and scientific research is now uncovering the potential mechanisms of action of biological active ingredients in these preparations. Many thousands of such compounds, mainly terpenes, including monoterpenes and sesquiterpenes, and also phenolic compounds, alcohols, aldehydes, esters and ketones have been identified in essential oils. Thanks to their chemical composition, essential oils possess numerous biological activities (e.g., antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral). Anecdotally, and in the practice of aromatherapists, they have been shown to enhance mental and physical well-being and provide refreshment from exhaustion. Increasingly they are used in aromatherapy practice in various disorders such as cardiovascular disorders, sleep disorders and Alzheimer's disease. This review evaluates laboratory and clinical evidence on a range of essential oils and their botanical ingredients.

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A Systematic Review of the Anti‐Inflammatory and Immunomodulatory Properties of 16 Essential Oils of Herbs

Cited by 29 publications

References 74 publications

Profile of Myracrodruon urundeuva Volatile Compounds Ease of Extraction and Biodegradability and In Silico Evaluation of Their Interactions with COX-1 and iNOS

Profile of Myracrodruon urundeuva Volatile Compounds Ease of Extraction and Biodegradability and In Silico Evaluation of Their Interactions with COX-1 and iNOS

Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review

A Science Review of Selected Essential Oils and their Botanical Ingredients. Focus on Essential Oils used for Respiratory and Calming Indications

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