A Systematic Review of the Circadian Rhythm of Bone Markers in Blood

Diemar, Sarah Seberg; Dahl, Stig Søgaard; West, Anders Sode; Simonsen, Sofie Amalie; Iversen, Helle K.; Jørgensen, Niklas Rye

doi:10.1007/s00223-022-00965-1

Cited by 20 publications

(20 citation statements)

References 61 publications

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“…A circadian rhythm in bone turnover markers is well known in healthy individuals ( Diemar et al, 2022 ).In the present study, we demonstrate for the first time that a circadian rhythm in the bone turnover markers is also present in CKD, although this does not appear to be caused by CKD in itself.…”

Section: Discussionsupporting

confidence: 64%

Circadian rhythm of markers of bone turnover in patients with chronic kidney disease

et al. 2022

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Section: Discussionsupporting

confidence: 64%

Circadian rhythm of markers of bone turnover in patients with chronic kidney disease

et al. 2022

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“…However, Sale et al suggested that even though carbohydrate feeding during exercise reduces overall bone turnover in the hours following exercise, the balance between resorption and formation markers is maintained (63). A recent review stated circadian variation for BTMs CTX-1 and OC, with nighttime or early morning peak, but with less amplitude for P1NP and none for sclerostin (64). We tried to minimize the effects of circadian variation for BTMs by drawing blood at the same time of the day for all participants.…”

Section: Study Strengths and Limitationsmentioning

confidence: 99%

Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

et al. 2022

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ContextExercise is recognized as an important strategy to prevent bone loss, but its acute effects on bone turnover markers (BTMs) and related markers remain uncertain.ObjectiveTo assess the acute effects of two different exercise modes on BTMs and related markers in young adults of both sexes and elderly men.Design, Setting, ParticipantsThis was a three-group crossover within-subjects design study with a total of 53 participants—19 young women (aged 22–30), 20 young men (aged 21–30 years), and 14 elderly men (aged 63–74 years)—performing two different exercise sessions [strength training (ST) and high-intensity interval training (HIIT)] separated by 2 weeks, in a supervised laboratory setting.Main Outcome MeasuresPlasma volume-corrected serum measurements of the BTMs C-terminal telopeptide of type 1 collagen (CTX-I) and procollagen of type 1 N-terminal propeptide (P1NP), total osteocalcin (OC), sclerostin, and lipocalin-2 (LCN2) at baseline, immediately after, and 3 and 24 h after each of the two exercise modes were performed.Results and ConclusionAnalyses revealed sex- and age-dependent differences in BTMs and related bone markers at baseline and time-, sex-, and age-dependent differences in response to exercise. No differences between exercise modes were observed for BTM response except for sclerostin in young men and LCN2 in elderly men. An acute, transient, and uniform increase in P1NP/CTX-1 ratio was found in young participants, demonstrating that beneficial skeletal effects on bone metabolism can be attained through both aerobic endurance and resistance exercise, although this effect seems to be attenuated with age. The acute effects of exercise on bone-related biomarkers were generally blunted after 24 h, suggesting that persistent alterations following prolonged exercise interventions should be assessed at later time points.

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“…Additionally, levels of sCOMP remain stable both within minutes (interday) and 1–2 days post-exertion (intraday), demonstrating both strong interday and intraday reliability [ 87 ]. Nonetheless, sCOMP levels fluctuate following circadian rhythmicity patterns, like CTX-II [ 88 ], so it is recommended that sampling is always performed at the same time of the day (best in the morning), and in patients that follow a stable dietary regime [ 88 ]. Furthermore, sCOMP appears to be better for the detection of knee OA, while CTX-II seems more specific for the detection of hip OA [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular Assessment of Healthy Pathological Articular Cartilages in Physically Active People: A Scoping Review

Petrigna

Trovato

Roggio

et al. 2023

IJMS

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Physiological aging triggers a cascade of negative effects on the human body and the human joint is only one of the several compartments affected by this irreversible and natural process. Osteoarthritis and cartilage degeneration can cause pain and disability; therefore, identifying the molecular processes underlying these phenomena and the biomarkers produced during physical activity is of critical importance. In the present review, the main goal was to identify and discuss the articular cartilage biomarkers analyzed in studies in which physical or sports activities were adopted and eventually to propose a standard operating procedure for the assessment. Articles collected from Pubmed, Web of Science, and Scopus were scrutinized to detect reliable cartilage biomarkers. The principal articular cartilage biomarkers detected in these studies were cartilage oligomeric matrix protein, matrix metalloproteinases, interleukins, and carboxy-terminal telopeptide. The articular cartilage biomarkers identified in this scoping review may aid in a better comprehension of where research on the topic is heading and offer a viable instrument for streamlining investigations on cartilage biomarker discovery.

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A Systematic Review of the Circadian Rhythm of Bone Markers in Blood

Cited by 20 publications

References 61 publications

Circadian rhythm of markers of bone turnover in patients with chronic kidney disease

Circadian rhythm of markers of bone turnover in patients with chronic kidney disease

Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

Molecular Assessment of Healthy Pathological Articular Cartilages in Physically Active People: A Scoping Review

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