A Systematic Review of the Efficacy of Domperidone for the Treatment of Diabetic Gastroparesis

Sugumar, Aravind; Singh, Akanksha; Pasricha, Pankaj J.

doi:10.1016/j.cgh.2008.02.065

Cited by 84 publications

(53 citation statements)

References 22 publications

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“…A systematic review of quali fi ed studies in adults found that approximately 64% of studies showed that domperidone was effective in improving symptoms of diabetic gastroparesis and 60% showed ef fi cacy in improving gastric emptying [ 10 ] . In cases of GERD without evidence of gastric dysmotility, domperidone does not provide increased bene fi t to adult patients in comparison to acid suppression alone [ 11 ] .…”

Section: Dopamine-2 (D2) Receptor Antagonists Domperidonementioning

confidence: 99%

Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

Har

Croffie

2012

Pediatric Neurogastroenterology

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Section: Dopamine-2 (D2) Receptor Antagonists Domperidonementioning

confidence: 99%

Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

Har

Croffie

2012

Pediatric Neurogastroenterology

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“…Pharmacist recommendation was to stop metoclopramide injections if the patients were able to take oral medications, or metoclopramide could be replaced with drugs having fewer adverse effects, such as domperidone syrup 3 × 10 mg ½ hr before mealtime. Research on metoclopramide and domperidone for diabetic gastroparesis showed that the two drugs have similar efficacy, but domperidone has fewer side effects of somnolence, akathisia, asthenia, anxiety, depression, and problems with mental acuity [13].…”

Section: Inappropriate Drug (Including Contraindicated): C 11mentioning

confidence: 99%

Pharmacist Involvement to Decrease Drug-Related Problems Among Geriatric Patients in Indonesian Primary Health Centers

Suryani¹,

Bahtiar

Andrajati

2017

Asian J Pharm Clin Res

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Objective:The studies have demonstrated that older people often suffer from multiple diseases and are thus prescribed many different drugs. Therefore, drug-related problems (DRPs) are common in the elderly. The main objectives of this study were to reduce the number of DRPs in the elderly through pharmacist involvement and to analyze differences after pharmacist recommendations. Methods:In a quasi-experimental study, 12 primary health centers were selected and randomly divided into two groups (six in each group). In the first group, the physicians received pharmacist recommendations verbally through discussions, and in the second group, the physicians received recommendations through letters. DRPs were analyzed from all older inpatients' medical records 1 month before and 1 month after the pharmacist recommendations. The main outcome being measured was the incidence of DRPs, classified into problems, and causes according to the Indonesian translated version of Pharmaceutical Care Network Europe, Version 6.2 (PCNE V 6.2). The problems were identified based on journal articles and other relevant literature.Results: A total of 205 patients were analyzed before pharmacist intervention (Group 1: 121; Group 2: 84) and 202 patients after the intervention (Group 1: 108; Group 2: 94). The most common problem in these elderly patients was that they suffered from toxic effects. The most common cause was inappropriate drug selection. The number of DRPs and causes were decreased significantly through the discussions (Wilcoxon signed-rank test, problems p=0.027, causes p=0.028). DRPs were also significantly decreased through the recommendation letters (paired t-test, number of problems p=0.003, and causes p=0.004). Discussion with physicians seemed more effective and decreased more problems (p=0.001) and causes (p=0.002). Through discussions, the decrease in a number of problems was 20.83±8.931, and the decrease in the number of causes was 25.33±11.431 versus the recommendation letter, at 4.17±1.941 and 5.17±2.483, respectively. Conclusion:Pharmacist involvement decreased DRPs among older inpatients. Discussing DRPs with the physicians treating the patients is more effective than giving recommendations in writing only. The PCNE V 6.2 DRP classification system is useful for documenting DRPs among the elderly as it can help pharmacists develop plans to reduce DRPs.

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“…Older prokinetic drugs, metoclopropamide and bethanechol, have frequent side-effects, and cisapride has been withdrawn or restricted in most countries. Domperidone (unavailable in the USA) has been used in the treatment of gastroparesis [125] and as part of a treatment regimen in two small studies of asthmatics with GERD [126,127], but it may prolong the QTc interval [128]. Finally, baclofen reduces the frequency of TLESR in GERD patients [129,130] but, to date, has not been well studied in clinical trials.…”

Section: Managementmentioning

confidence: 99%

Gastro-oesophageal reflux disease and non-asthma lung disease

Morehead¹

2009

European Respiratory Review

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Gastro-oesophageal reflux disease (GERD) is a common disorder in Western countries, and its relationship to airways disorders (e.g. asthma) has been well established. Lung diseases other than asthma have also been associated with GERD, but the nature and scope of this relationship has not been fully defined. Diseases that have been associated with GERD include bronchiolitis syndromes, idiopathic pulmonary fibrosis, scleroderma and nontubercular mycobacterial infection.Diagnostic evaluation centres upon proving both reflux and pulmonary aspiration, which may be accomplished in some cases by lung biopsy. However, in many cases a compatible clinical and radiographic picture coupled with proof of proximal reflux by combined oesophageal probe testing may suffice for a provisional diagnosis and allow institution of anti-reflux measures.Proton-pump inhibitors are the medications of choice for GERD; other interventions shown to reduce reflux are weight loss, elevation of the head of the bed and avoidance of recumbency after meals. However, acid suppression therapy does not address non-acid reflux that may be important in disease pathogenesis in select patients, and lifestyle modifications often fail.Laparoscopic fundoplication is the procedure of choice for medically refractory GERD with excellent short-term results with respect to respiratory symptoms associated with GERD; however, long-term studies document a significant percentage of patients requiring ongoing acid suppression therapy.

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A Systematic Review of the Efficacy of Domperidone for the Treatment of Diabetic Gastroparesis

Cited by 84 publications

References 22 publications

Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

Pharmacist Involvement to Decrease Drug-Related Problems Among Geriatric Patients in Indonesian Primary Health Centers

Gastro-oesophageal reflux disease and non-asthma lung disease

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