A Systematic Review of the Wound-Healing Effects of Monoterpenes and Iridoid Derivatives

Abstract

Abstract:The search for more effective and lower cost therapeutic approaches for wound healing remains a challenge for modern medicine. In the search for new therapeutic options, plants and their metabolites are a great source of novel biomolecules. Among their constituents, the monoterpenes represent 90% of essential oils, and have a variety of structures with several activities such as antimicrobial, anti-inflammatory, antioxidant and wound healing. Based on that, and also due to the lack of reviews concerning the wound-healing activity of monoterpenes, we performed this systematic review-which provides an overview of their characteristics and mechanisms of action. In this search, the terms "terpenes", "monoterpenes", "wound healing" and "wound closure techniques" were used to retrieve articles published in LILACS, PUBMED and EMBASE until May 2013. Seven papers were found concerning the potential wound healing effect of five compouds (three monoterpenes and two iridoid derivatives) in preclinical studies. Among the products used for wound care, the films were the most studied pharmaceutical form. Monoterpenes are a class of compounds of great diversity of biological activities and therapeutic potential. The data reviewed here suggest that monoterpenes, although poorly studied in this context, are promising compounds for the treatment of chronic wound conditions.

Properties and Applications of Morinda citrifolia (Noni): A Review

“…Iridoids are compounds derived from geraniol belonging to the class of monoterpenes. A subclass of the iridoids are the iridoid glycosides, which are terpenes bound to glucose molecules (Barreto et al, 2014). described the isolation from the leaf extract of M. citrifolia of a new iridioid glycoside, called citrifolinoside A, along with two other known iridoid glycosides, asperuloside and asperulosidic acid.…”

“…Iridoids are compounds derived from geraniol belonging to the class of monoterpenes. A subclass of the iridoids are the iridoid glycosides, which are terpenes bound to glucose molecules (Barreto et al., ). Sang et al.…”

Inclusion of terpenes in cyclodextrins: Preparation, characterization and pharmacological approaches

“…There is a wide range of possible therapeutic pharmacological uses for terpenes including as: anticancer drugs, analgesics, anti-inflammatories, neuroprotective agents, immune modulators and in wound healing (Ali et al, 2013; Araujo-Filho, Quintans-Junior, Barreto, Almeida, Barreto & Quintans, 2016;Barreto et al, 2014; In general, terpenes represent a heterogeneous group of chemical substances constructed from hydrocarbons. They consist of the combination of several 5-carbon-base units called isoprenes (C5H8), mainly in a head-to-tail linkage.…”

Wound Healing Activity of Aucubin on Hyperglycemic Rat

“…2 Aucubin activities have been extensively studied, such as for anticancer, 2-3 immunomodulator, 2 and for the treatment of mucous membrane inflammation of nasopharyngeal channels. 4 In addition, aucubin also has wound healing activity on oral mucous and dermal wound, 5 as well as inhibit the growth of Escherichia coli and Staphylococcus aureus. 6 However, so far there has been no report on aucubin activity for diabetic wound healing.…”