A systematic review of the local field potential adaptations during conditioned place preference task in preclinical studies

Abstract

Addiction is a global concern with a high relapse rate and without effective therapeutic options. Developing new effective therapeutic strategies is impossible without discovering the disease's neurobiological basis. The present systematic review aimed to comprehensively recognize and discuss the role of local field potentials from brain areas essential in forming and storing context-drug/food associations following the conditioned place preference (CPP) paradigm as a popular animal model of reward and addiction. Qualified studies were incorporated by a broad search of four databases, including Web of Science, Medline/PubMed, Embase, and ScienceDirect, in July 2022, and they were evaluated via appropriate methodological quality assessment tools.The current study found that drug-seeking behavior in different stages of the CPP paradigm is accompanied by alterations in neural oscillatory activity and adaptations in connectivity among various areas such as the hippocampus, nucleus accumbens, basolateral amygdala, and prelimbic area, intensely engaged in reward-related behaviors.These findings need to be extended by more future advanced studies to finally recognize the altered oscillatory activity patterns of large groups of cells in regions involved in reward-context associations to improve clinical strategies such as neuromodulation approaches to modify the abnormal electrical activity of these critical brain regions and their connections for treating addiction and preventing drug/food relapse in abstinent patients. Definitions:• Power is the amount of energy in a frequency band and is the squared amplitude of the oscillation.• Cross-frequency coupling refers to a statistical relationship between activities in two different frequency bands.• Phase-amplitude coupling is perhaps the most commonly used method of computing cross-frequency coupling. Phase-amplitude coupling involves testing for a relationship between the phase of one frequency band and the power of another, typically relatively higher, frequency band. Thus, within phase-amplitude coupling, you refer to the "frequency for phase" and the "frequency for power."Mojdeh Fattahi and Shaghayegh Modaberi equally contributed to this work.

Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling

“…Conditioning hypotheses, which are also rooted in drug-related environment stimuli to cause drug use, have a proven neurobiological basis linking dopaminergic transmission to drug-related cues and stress ( WEISS et al, 2001 ). Furthermore, the different stages of condition placed preference (CPP), a leading behavioural model, have been intrinsically linked to specific neural alterations ( Fattahi et al, 2023 ).…”