A systematic review of the long-term effects of dental development disturbances after hematopoietic stem-cell transplantation in pediatric patients

Impact of Pediatric Hematopoietic Stem-Cell Transplantation on Craniofacial Growth

“…The main limitation of this study was the impossibility of separately studying the different myeloablative regimens due to the high individualization of chemotherapeutic agents to minimize the side effects. However, this limitation does not invalidate the present results since no differences were observed between the prevalence of dental anomalies and different myeloablative chemo-radiotherapy protocols ( 14 ).…”

“…The sample size was estimated before data collection based on a review of previous studies ( 10 , 13 , 14 ). A primary error probability of 5% and statistical power of 80% was assumed.…”

“…Impaired skeletal growth and development have been associated to reduce bone mineral density in the femur, vertebrae, and jaws ( 10 - 13 ). Craniofacial and dental development disturbances have been described to be more prevalent in children submitted to HSCT at a young age (<10 years) ( 14-16 ,). Impaired skeletal growth in long-term childhood HSCT survivors negatively affects their quality of life ( 6 , 12 , 13 ).…”

Estudo do crescimento e desenvolvimento craniofaciais em pacientes pediátricos transplantados de células-tronco hematopoiéticas

“…Alterações dentárias são mais prevalentes em pacientes transplantados antes dos cinco anos de idade (Frascino et al, 2014). Esses pacientes apresentam maior risco de desenvolver doença periodontal agressiva e perda dentária precoce (Osiak et al, 2018).…”

“…As alterações dentárias mais comuns são a agenesia, a microdontia, a perda da proporção coroa/raiz e o fechamento precoce dos ápices radiculares, com maior incidência nos dentes pré-molares superiores e segundos molares inferiores permanentes (Frascino et al, 2014). Também são descritos: aumento do risco de doenças periodontais, perdas dentárias precoces, xerostomia, halitose, sangramentos gengivais e disgeusia (Osiak et al, 2018).…”