A systematic review of the prognostic value of motor abnormalities on clinical outcome in psychosis

Pieters, L; Nadesalingam, Niluja; Walther, Sebastian; Harten, Peter N. van

doi:10.1016/j.neubiorev.2021.11.027

Cited by 22 publications

(18 citation statements)

References 125 publications

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“…We did not perform formal tests of replicability across cohorts, as it was outside the scope of this study. Second, though evidence showing the relationship between increased motor abnormalities and poor functional outcome demonstrates the clinical relevance that motor abnormalities play psychosis spectrum disorders (Pieters et al., 2021), we did not systematically assess motoric side effects in this study. However, we did motion scrub functional scans at the subject level and included FD as a covariate of no interest to help mitigate any potential movement confounds that may have existed within our functional connectivity data.…”

Section: Discussionmentioning

confidence: 99%

Dorsal striatal hypoconnectivity predicts antipsychotic medication treatment response in first‐episode psychosis and unmedicated patients with schizophrenia

et al. 2022

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Introduction:The dorsal striatum, comprised of the caudate and putamen, is implicated in the pathophysiology of psychosis spectrum disorders. Given the high concentration of dopamine receptors in the striatum, striatal dopamine imbalance is a likely cause in cortico-striatal dysconnectivity. There is great interest in understanding the relationship between striatal abnormalities in psychosis and antipsychotic treatment response, but few studies have considered differential involvement of the caudate and putamen. This study's goals were twofold. First, identify patterns of dorsal striatal dysconnectivity for the caudate and putamen separately in patients with a psychosis spectrum disorder; second, determine if these dysconnectivity patterns were predictive of treatment response.Methods: Using resting state functional connectivity, we evaluated dorsal striatal connectivity using separate bilateral caudate and putamen seed regions in two cohorts of subjects: a cohort of 71 medication-naïve first episode psychosis patients and a cohort of 42 unmedicated patients with schizophrenia (along with matched controls).Patient and control connectivity maps were contrasted for each cohort. After receiving 6 weeks of risperidone treatment, patients' clinical response was calculated. We used regression analyses to determine the relationship between baseline dysconnectivity and treatment response.Results: This dysconnectivity was also predictive of treatment response in both cohorts.Discussion: These findings suggest that the caudate may be more of a driving factor than the putamen in early cortico-striatal dysconnectivity.

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Section: Discussionmentioning

confidence: 99%

Dorsal striatal hypoconnectivity predicts antipsychotic medication treatment response in first‐episode psychosis and unmedicated patients with schizophrenia

et al. 2022

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“…BOT‐2 can provide a more detailed picture of motor performance in clinical and research settings, potentially helping to optimize early identification and providing effective interventions. Providing a more detailed picture of motor performance may additionally be of importance due to studies suggest that movement impairments are of prognostic value, as they may be related to functional outcome in schizophrenia and may predict the development and course of schizophrenia over time (Pieters et al., 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Besides the health implications, as cardiovascular disease is a critical concern, especially in schizophrenia patients (Henderson et al., 2015), the identification of motor impairments in adolescents with schizophrenia is also important as this may be of prognostic value. Motor impairments may be markers that predict the development and course of schizophrenia (Hirjak et al., 2018; Pieters et al., 2022; van Harten et al., 2017; Walther & Mittal, 2017). Studies also suggest that motor impairments relate to the functional outcome of schizophrenia over time (Pieters et al., 2022).…”

Section: Introductionmentioning

confidence: 99%

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Comparing the Movement Assessment Battery for Children with the Bruininks‐Oseretsky Test of Motor Proficiency in adolescents with and without schizophrenia

Byrial

Clausen

Nyboe

2022

Physiotherapy Res Intl

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Background As motor impairments have implications for health and functioning, they need to be addressed early, not only in childhood but also in adolescence, the period in which mental disorders as schizophrenia, typically develops. Further, the possible prognostic value of motor impairments in schizophrenia highlights the importance. The Bruininks‐Oseretsky Test of Motor Proficiency (BOT‐2) and the Movement Assessment Battery for Children (MABC‐2) assess adolescent motor performance. However, MABC‐2 is not valid past age 16 and has no sex‐norms. Further, while the concurrent validity between the tests and their ability to distinguish between clinical and non‐clinical groups has been established in children, however they have not been established in adolescence. Purpose To compare the ability of MABC‐2 and BOT‐2 to distinguish between adolescents with and without schizophrenia, to examine the concurrent validity between tests, to examine the agreement between tests in classifying adolescents “at risk” or scoring “below average” and to examine the influence of age and sex on MABC‐2. Method Motor performance assessed by BOT‐2 and MABC‐2 was compared in 25 adolescents with schizophrenia (14–18) and age‐ and sex‐matched controls using t‐test, Cohen's D and false discovery rate's q‐value. The associations between tests were assessed using Pearson's correlation and Lin's concordance correlation coefficient. The Kappa coefficient was used to assess the agreement between tests in classifying “risk/below average” and linear regression was adopted to assess the influence of age/sex on MABC‐2. Results MABC‐2 and BOT‐2 significantly distinguished adolescents with schizophrenia from controls with large effect size. A strong association (p > 0.001) was found between the tests. The tests revealed moderate agreement in identifying “risk” or scoring “below average”. Only sex influenced MABC‐2 scores. Conclusion MABC‐2 and BOT‐2 are both useful for assessing motor performance and distinguishing between adolescents with and without schizophrenia, although BOT‐2 provides a more detailed picture of the challenges in adolescent with schizophrenia.

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“…Motor abnormalities are frequently observed in patients with schizophrenia and related psychoses and may have clinical and prognostic relevance [1]. Of these, catatonia may be the most intriguing and challenging in terms of presentation and diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Catatonia Due to General Medical Conditions in Psychiatric Patients: Implications for Clinical Practice

Peritogiannis¹,

Rizos

2023

Psychiatry International

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Catatonic syndrome is frequently observed over the course of severe mental disorders and general medical conditions, but when catatonia occurs in psychiatric patients with co-morbid medical or neurologic conditions, diagnosis and management may be challenging. Several medical conditions may cause catatonia in psychiatric patients, but some, such as brain injury, infections, hyponatremia and critical illness, may be most relevant in this population. Alongside appropriate etiologic treatment, benzodiazepines and electroconvulsive therapy in refractory cases are effective and safe, and may resolve catatonic syndrome rapidly. When newly-onset psychotic symptoms in catatonic patients with established psychotic disorders occur, delirium should be suspected and appropriately managed. An extensive clinical and laboratory diagnostic workup to determine the underlying etiology of catatonic syndrome should be carried out. In cases of acute multi-morbidity, the exact cause of catatonic syndrome in psychiatric patients may be unclear. It is recommended to avoid antipsychotic drugs in acutely catatonic patients, because they may exacerbate the catatonic symptoms. The akinetic type of catatonia should be differentiated from hypoactive delirium, as treatments for these syndromes differ substantially. When a psychiatric patient presents with symptomatology of both catatonia and delirium, treatment is particularly challenging.

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A systematic review of the prognostic value of motor abnormalities on clinical outcome in psychosis

Cited by 22 publications

References 125 publications

Dorsal striatal hypoconnectivity predicts antipsychotic medication treatment response in first‐episode psychosis and unmedicated patients with schizophrenia

Dorsal striatal hypoconnectivity predicts antipsychotic medication treatment response in first‐episode psychosis and unmedicated patients with schizophrenia

Comparing the Movement Assessment Battery for Children with the Bruininks‐Oseretsky Test of Motor Proficiency in adolescents with and without schizophrenia

Catatonia Due to General Medical Conditions in Psychiatric Patients: Implications for Clinical Practice

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