A systematic review of the clinical and radiographic features of hybrid central giant cell granuloma lesions of the jaws

Alsufyani, Noura; Aldosary, Reem; Alrasheed, Rasha S; Alsaif, Rand F

doi:10.1080/00016357.2020.1797160

Cited by 11 publications

(5 citation statements)

References 35 publications

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“…In this case, the main lesion was over 1 cm, and it affected the neighboring skull base radiologically, so it was more likely to be diagnosed as an osteoblastoma. Giant cell lesions of the jaws also show similar radiographic and clinical features to osteoblastoma (22). However, giant cell lesions of the jaws are always composed of fibrous connective tissue, irregularly distributed multinucleated giant cells, abundant blood vessels, a little bone-like tissue, and a large amount of hemosiderin in histopathological slices (23), so they can be distinguished accordingly.…”

Section: Differentiation Diagnosismentioning

confidence: 99%

Temporal bone osteoblastoma involving temporomandibular joint diagnosed as simple disc disorders: A case report

Zhao

Zhang²,

Pan³

et al. 2023

Front. Surg.

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BackgroundOsteoblastoma is quite rare in the oromaxillo-facial region, while the mandible is always the predilection. However, in our case, the lesion was located in the left temporal articular tubercle, involving the adjacent skull base, which is extremely rare in the literature.Case reportsIt had been diagnosed as the most common temporomandibular joint disorder in the local hospital before the patient came to our department, mainly due to the primary symptom, that was, the patient got pain in the left temporomandibular joint area while opening the mouth. However, we found a mass of bone lesions at the left temporal articular tubercle in MRI and cone beam CT, and it turned out to be an osteoblastoma after surgery. The patient's primary symptom disappeared after recovering from the surgery, and there have been no indications of complication or recurrence up to now.ConclusionOsteoblastoma is very rare in the temporomandibular joint region. It could easily miss the possibility of a benign tumor due to its unusual location and confusing chief complaint in this case. Our report provides experience in the identification of osteoblastoma in rare sites.

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Section: Differentiation Diagnosismentioning

confidence: 99%

Temporal bone osteoblastoma involving temporomandibular joint diagnosed as simple disc disorders: A case report

Zhao

Zhang²,

Pan³

et al. 2023

Front. Surg.

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“…1 Several reports suggest there are three theories for its development 1) reactive origin to a local irritant, 2) development anomaly and 3) neoplastic etiology. [2][3][4] CGCG is more commonly found in the mandible and mainly in a young females. 2 It can be seen classified as "aggressive" or "non-aggressive" radiologically, clinically, and histologically (Table 1).…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4] CGCG is more commonly found in the mandible and mainly in a young females. 2 It can be seen classified as "aggressive" or "non-aggressive" radiologically, clinically, and histologically (Table 1). 2,[4][5][6]…”

Section: Introductionmentioning

confidence: 99%

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Implant-Associated Giant Cell Granuloma: A Case Report of 4.8-Year Follow-up and Literature Review.

ESKAN¹

2022

Selcuk Dental Journal

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Implant-Associated Giant Cell Granuloma: A Case Report of 4.8-Year Follow-up and Literature Review.Objective. The aim of this case report was to document a case of implant associated central giant cell granuloma (CGCG) and review the literature on implant associated and intrabony lesions. CGCG is most common in females and usually seen in the mandible from anterior to posterior. Based on its clinical, radiological, and histological findings, it can be classified as aggressive and non-aggressive forms. Trauma is considered a major etiological factor for the lesion. Even peripheral giant cell granuloma has been shown as a peri-implant lesion, CGCG has not been reported as an implant-associated pathology. In this case report, we reported that CGCG developed after implant placement in 8 months. 39-year-old female patient with partial edentulism in the posterior mandible presented to our clinic. She had reported that she lost her posterior mandible teeth for more than six years. Initial clinical and radiological examination revealed that she showed localized slight to moderate chronic periodontitis, horizontal ridge deficiency (in the posterior mandible), and cavities. A total of six implants were placed at the same time. At 8month of the surgery, she showed a radiolucency area #34 area. The lesion was enucleated, and the defect area was filled up with a xenogeneic bone substitute. The healing was uneventful. The histological examination determined the lesion was CGCG. The lesion showed no recurrency for 4.8 years.

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“…The second claims that CGCG is a developmental anomaly, while the third implies that such a lesion has a neoplastic attribution. 2,[4][5][6] In 1986, Chuong and co-workers 3 documented a series of 17 cases of CGCG of the jaws in children and adolescents, among whom aggressive CGCG was observed, characterized by pain, rapid growth, root resorption, cortical perforation, with a mean diameter of 5.8 cm, and a high rate of recurrence. Since the varied biological behavior of CGCG is not linked to histopathological features or molecular alterations and does not allow the practitioner to determine the prognosis of this condition, 7,8 some studies have indicated that the relative percentage of giant cells and immunohistochemically stained mononuclear cells for glucocorticoid and/or calcitonin receptors can be used as a reliable and effective tool for selecting the optimal treatment for individuals with CGCG.…”

Section: Introductionmentioning

confidence: 99%

Central giant cell granuloma of the maxilla: Long‐term follow‐up of a patient treated with an adjuvant corticosteroid

Arruda

Martins

Abreu

et al. 2021

Special Care in Dentistry

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Background: Central giant cell granuloma (CGCG) is one of the most intriguing lesions of the jaws and its nature has not yet been fully elucidated. Clinically, some CGCG behave more aggressively, while others have an indolent course.In cases of aggressive CGCG of the maxilla, effective personalized therapies are worth understanding. Case report:We report here a challenging case of aggressive CGCG in a 15-yearold girl which was misdiagnosed as an endodontic lesion. Radiographically, a large osteolytic lesion involving the hard palate from the central incisor to the second premolar, extending into the nasal cavity, with loss of the lamina dura and cortical resorption was observed. The lesion expanded aggressively after extensive curettage. With possible mutilation and defects due to a more radical approach to the lesion, treatment with systemic prednisone and intralesional triamcinolone hexacetonide associated with a calcitonin nasal spray was instituted. The decision in favor of this therapeutic strategy was made after careful immunohistochemical analysis of calcitonin and glucocorticoid receptors. The H-score for the staining of glucocorticoid and calcitonin receptors in multinucleated giant cells was 222 and 153.6, respectively. The lesion reduced in size, and no adverse effects associated with medications were observed. Another curettage was performed, and only fibrous connective tissue was found. The patient is in follow-up for 11 years without evidence of recurrence. Conclusion: Pharmacological agents hold clinical promise in cases of aggressive CGCG affecting the maxilla of pediatric patients. Investigating the expression of calcitonin and glucocorticoid receptors in order to plan treatment is very helpful in the decision to manage aggressive CGCG.

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A systematic review of the clinical and radiographic features of hybrid central giant cell granuloma lesions of the jaws

Cited by 11 publications

References 35 publications

Temporal bone osteoblastoma involving temporomandibular joint diagnosed as simple disc disorders: A case report

Temporal bone osteoblastoma involving temporomandibular joint diagnosed as simple disc disorders: A case report

Implant-Associated Giant Cell Granuloma: A Case Report of 4.8-Year Follow-up and Literature Review.

Central giant cell granuloma of the maxilla: Long‐term follow‐up of a patient treated with an adjuvant corticosteroid

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