A systematic review of the clinical effectiveness and cost-effectiveness of Pharmalgen® for the treatment of bee and wasp venom allergy.

Abstract

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Honeybee venom possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer cell line

“…4B). These data support the , and those treated with 2.5 mg/kg of BV reached 839±122 mm 3 . In addition, at day 15 after treatment, the 2.5 mg/kg BV-treated TC-1 tumor group showed that the tumor growth was significantly suppressed as compared with the 1.0 mg/kg BV-treated group (P<0.0001) and with the PBS group (P<0.0001).…”

“…TC-1 tumors were implanted in the abdomens of 4-to 5-week old female C57BL/6 mice by subcutaneous injection of 5x10 5 TC-1 cells in 100 µl of serum and antibiotic-free DMEM media (Gibco-BRL). When tumors reached a volume of 150-200 mm 3 , mice were randomly assigned to one of three groups to receive PBS, 1 mg/kg BV and 2 mg/kg BV (5 mice/group). The first day of treatment was designated as day 1.…”

“…BV has been used as a traditional medicine to treat back pain, rheumatism and skin diseases by its antibacterial, antiviral and anti-inflammatory effects (2)(3)(4). BV is a rich source of enzymes and peptides, including melittin, phospholipase A2 (PLA2), apamin, adolapin and mast cell-degranulating peptide (MCDP) (5)(6)(7).…”

Insect Venom Immunotherapy: Analysis of the Safety and Tolerance of 3 Buildup Protocols Frequently Used in Spain

“…Ultrarush protocols have been shown to be safe [9,12,[15][16][17]; however, other prospective studies have shown a rapid increase in dose to be an independent risk factor for adverse systemic reactions [13,18]. In the case of ultrarush protocols, this risk is increased 1.8-fold, although the protocols are costeffective [19,20]. We chose 3 protocols that had already been successfully tested by different groups in Spain [8,21] and are the approach used in most allergy departments in Spain.…”

À qui prescrire un dispositif auto-injectable d’adrénaline ? Position des groupes de travail « Anaphylaxie », « Allergie alimentaire », « Insectes piqueurs » sous l’égide de la Société française d’allergologie

“…[28]. Les revues systématiques et méta-analyses ont montré l'efficacité de l'immunothérapie par voie sous-cutanée dans l'allergie aux hyménoptères chez l'enfant et l'adulte (Grade A) [29][30][31]. La qualité de vie des patients recevant une immunothérapie est meilleure que celle des patients disposant d'un stylo d'adrénaline seul [32][33][34].…”