A Systematic Review of the Effect of Cancer Treatment on Work Productivity of Patients and Caregivers

Abstract

This study was funded by Novartis Pharmaceuticals, which provided the concept, general oversight, and research collaboration on the project. Covvey and Kamal received research funding from Novartis Pharmaceuticals and the College of Psychiatric and Neurologic Pharmacists. Zacker is employed by, and owns stock in, Novartis Pharmaceuticals. A related poster abstract was presented at the Academy of Managed Care Pharmacy April 2016 Annual Meeting and published as Kamal KM, Covvey JR, Dashputre A, Ghosh S, Zacker C. A conceptual framework for valuebased oncology treatment: a societal perspective. J Manag Care Spec Pharm. 2016;22(4 Suppl A):S28. A publication-only abstract was presented at the American Society of Clinical Oncology 2016 Annual Meeting and published as Covvey JR, Kamal KM, Dashputre A, Ghosh S, Zacker C. The impact of cancer treatment on work productivity of patients and caregivers: a systematic review of the evidence. J Clin Oncol. 2016;34(Suppl):e18249. Study concept and design were contributed by Zacker, Kamal, and Covvey. Dashputre and Ghosh took the lead in data collection, along with Kamal and Covvey, and data interpretation was performed primarily by Shah and Bhosle, along with Ghosh, Dashputre, Covvey, and Kamal. The manuscript was written by Kamal, Covvey, Shah, and Bhosle and revised primarily by Zacker, along with Shah, Bhosle, Kamal, and Covvey.

Productivity losses in patients with newly diagnosed multiple myeloma following stem cell transplantation and the impact of maintenance therapy

“…However, 80% of overall productivity loss was due to patients feeling unable to return to work post‐ASCT, with many stating that they lacked the fitness to conduct daily duties effectively. These findings support a recent international systematic review of productivity loss across a broad range of cancers, including leukaemia, which highlighted that productivity losses were often associated with disease progression and patients feeling unable to carry out their previous roles …”

Impact of lower urinary tract symptoms on work productivity in female workers: A systematic review and meta‐analysis

“…Types of outcomes: The outcome of interest was work productivity including absenteeism, presenteeism, loss of work productivity, work impairment, sick leave, missed work, time away from work, work ability, short‐term disability, use of ancillary services, workforce dropout, employment, and long‐term disability …”

Wage losses among spouses of women with nonmetastatic breast cancer

“…Recent systematic and scoping reviews have reported that cancer negatively affects the employment of spouses of patients with cancer in terms of decreased productivity and work absences. Although a few studies have estimated how decreased productivity and work absences translate into spouses' wage losses, most have focused on cancers other than breast cancer or mixed groups including breast cancer with varying disease stages or only advanced disease, and this makes it impossible to isolate specifically the effect of nonmetastatic breast cancer on spouse wage losses.…”