A Systematic Review of the Quality of Evidence of Ablative Therapy for Small Renal Masses

Kang, Diana; Palmer, Drew; Zarei, Mina; Shah, Prithvi; Folsom, Craig; Beyth, Rebecca J.; Stoffs, Taryn; Neuberger, Molly M.; Dahm, Philipp

doi:10.1016/j.juro.2011.09.046

Cited by 22 publications

(2 citation statements)

References 16 publications

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“…But in recent years, novel minimally invasive procedures [e.g., radio frequency ablation (RFA)] have been increasingly applied (10). The principle of RFA is to destroy the tumor tissues with heat and desiccation by radio frequency current, which can be performed through open incisions, laparoscopic or percutaneous routes under image guidance [i.e., ultrasound (US), magnetic resonance imaging (MRI), computed tomography (CT)] (11)(12)(13).…”

Section: Traditional Surgical Treatment Of Renal Tumors Hasmentioning

confidence: 99%

Comparative outcomes of radio frequency ablation versus partial nephrectomy for T1 renal tumors: a systematic review

Wei¹,

Ren²,

Ding³

et al. 2019

Transl Androl Urol

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Background: The role of radio frequency ablation (RFA) in small renal tumors remains controversial. This systematic review was performed to compare clinical outcomes of RFA versus partial nephrectomy (PN) for the treatment of T1 renal tumors. Methods: A total of 11 studies including 2,397 patients were analyzed in this systematic review after searching the databases of PubMed, EMBASE and Web of Science. P value and odds ratio (OR)/hazard ratio (HR) with 95% confidence interval (CI) were used to evaluate the strength of the association.Results: A total of six studies (2,056 patients) provided either survival curves or HR and its 95% CI, demonstrating that the majority of the patients with RFA treatment tended to exhibit a similar long-term survival rate to those with PN treatment. In addition, according to four studies, no differences were found in the overall rate of complications between the two groups. Furthermore, there were significant differences in glomerular filtration rate (GFR) change between the two methods in four studies but no differences were observed in other two.Conclusions: Our systematic review indicated that RFA is an effective treatment option which could provide comparable oncologic outcomes to PN. Moreover, it may present obvious advantages in renal function preservation.

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Section: Traditional Surgical Treatment Of Renal Tumors Hasmentioning

confidence: 99%

Comparative outcomes of radio frequency ablation versus partial nephrectomy for T1 renal tumors: a systematic review

Wei¹,

Ren²,

Ding³

et al. 2019

Transl Androl Urol

View full text Add to dashboard Cite

show abstract

“…I risultati oncologici delle terapie focali, ed in particolare quelli della crioablazione e dell'ablazione con radiofrequenze sono limitati da follow-up modesti se comparati alla chirurgia nephron-sparing. Altre limitazioni sono dovute a bias (pecche) nel disegno degli studi presenti in letteratura e dall'assenza di raccolte dati standardizzate (3).…”

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Focal Therapy in Urology: Kidney Cancer

et al. 2013

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Focal therapy has gained attention in the treatment of small renal masses (SRM). However, its use is limited due to scarce data on long-term outcomes. The availability of such data is significantly lower as compared to the relevant data on surgery outcomes. At the same time, minimally invasive surgery has seen the development of laparoscopic nephron-sparing surgery and, recently, robot-assisted surgery. Our purpose is to review the possibilities of treatment for SMR with particular attention on focal therapy. Clinical series and comprehensive reviews support safety and mid/long-term efficacy of renal cryoablation or radiofrequency ablation. Comparative studies and meta-analysis outlined oncological inferiority against partial nephrectomy in local tumor control. For smaller and more peripheral lesions, radiofrequency ablation showed best indications than cryoablation. There are significant demographic and tumor differences between patients treated by one or another approach. The correct indication for each treatment seems to be of key importance to achieve the best oncological and functional outcome. Open partial nephrectomy remains the gold standard treatment for PMR, but laparoscopic approaches have been showing similar results.

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Epidemiology and Biology of Small Renal Masses

Crispen

Campbell

2013

Percutaneous Renal Surgery

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A Systematic Review of the Quality of Evidence of Ablative Therapy for Small Renal Masses

Cited by 22 publications

References 16 publications

Comparative outcomes of radio frequency ablation versus partial nephrectomy for T1 renal tumors: a systematic review

Comparative outcomes of radio frequency ablation versus partial nephrectomy for T1 renal tumors: a systematic review

Focal Therapy in Urology: Kidney Cancer

Epidemiology and Biology of Small Renal Masses

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