A systematic review of the health-related quality of life and economic burdens of anorexia nervosa, bulimia nervosa, and binge eating disorder

Ágh, Tamás; Kovaćs, Gábor L.; Supina, Dylan; Pawaskar, Manjiri; Herman, Barry K.; Vokó, Zoltán; Sheehan, David V.

doi:10.1007/s40519-016-0264-x

Cited by 278 publications

(181 citation statements)

References 88 publications

(200 reference statements)

Supporting

Mentioning

174

Contrasting

Unclassified

Order By: Relevance

“…So-called “food addiction” has been hypothesized to underlie many cases of obesity and eating disorders, which may collectively comprise the most prevalent and deadliest form of addictive behavior (Agh et al, 2016; Fichter & Quadflieg, 2016; Flegal, Kit, Orpana, & Graubard, 2013; Flegal, Kruszon-Moran, Carroll, Fryar, & Ogden, 2016; Hoang, Goldacre, & James, 2014; Kroes, Osei-Assibey, Baker-Searle, & Huang, 2016; Micali et al, 2017; Mitchell, 2016; Olguin et al, 2017; Perez, Ohrt, & Hoek, 2016; Smink, van Hoeken, & Hoek, 2013; Westmoreland, Krantz, & Mehler, 2016). In the United States, ~3 of 4 men and 2 of 3 women were overweight (25<body mass index [BMI]<30) or obese (BMI>30) in 2013–2014, and ~33% of overweight/obese people (and ~54% of patients undergoing bariatric surgery for obesity) met diagnostic criteria of the Yale Food Addiction Scale (Flegal et al, 2016; Long, Blundell, & Finlayson, 2015; Pursey, Stanwell, Gearhardt, Collins, & Burrows, 2014).…”

Section: Compulsive Eatingmentioning

confidence: 99%

Corticotropin-Releasing Factor (CRF) and Addictive Behaviors

Roberto

Spierling

Kirson

et al. 2017

International Review of Neurobiology

View full text Add to dashboard Cite

Drug addiction is a complex disorder that is characterized by compulsivity to seek and take the drug, loss of control in limiting intake of the drug, and emergence of a withdrawal syndrome in the absence of the drug. The transition from casual drug use to dependence is mediated by changes in reward and brain stress functions and has been linked to a shift from positive reinforcement to negative reinforcement. The recruitment of brain stress systems mediates the negative emotional state produced by dependence that drives drug seeking through negative reinforcement mechanisms, defined as the “dark side” of addiction. In this chapter we focus on behavioral and cellular neuropharmacological studies that have implicated brain stress systems (i.e., corticotropin-releasing factor [CRF]) in the transition to addiction and the predominant brain regions involved. We also discuss the implication of CRF recruitment in compulsive eating disorders.

show abstract

Section: Compulsive Eatingmentioning

confidence: 99%

Corticotropin-Releasing Factor (CRF) and Addictive Behaviors

Roberto

Spierling

Kirson

et al. 2017

International Review of Neurobiology

View full text Add to dashboard Cite

show abstract

“…Second, we examined whether these groups differed in condition-specific psychopathology (i.e., overall ED psychopathology and NSSI frequency) and quality of life. While worse quality of life is associated with EDs and NSSI (e.g., Agh et al, 2016; Ammerman, et al, 2017) and may convey a more severe clinical presentation, quality of life has not been investigated among those with both ED and NSSI. Based on an additive model of psychopathology, we expected that the co-occurring group would exhibit greatest severity condition-specific psychopathology and impairment in quality of life.…”

Section: Introductionmentioning

confidence: 99%

Emotional reactivity in a clinical sample of patients with eating disorders and nonsuicidal self-injury

Hayes

Styer

Washburn

2017

Psychiatry Research

View full text Add to dashboard Cite

Emotional reactivity is theorized to contribute to both eating disorders (ED) and nonsuicidal self-injury (NSSI). Although EDs and NSSI frequently co-occur, no study has examined emotional reactivity in individuals with both conditions. This study examined the following hypotheses in a large clinical sample (N=648): (1) patients with co-occurring ED and NSSI would report higher emotional reactivity and more severe clinical characteristics; (2) among those with EDs, patients with bulimia nervosa (BN) would be more likely to report NSSI and evidence the highest emotional reactivity; and (3) higher emotional reactivity would be associated with worse treatment outcomes. Data were collected at admission and discharge from inpatient, partial hospitalization, and intensive outpatient treatment programs for ED or NSSI. The NSSI-only and co-occurring groups reported significantly higher emotional reactivity than the ED-only group. Among those with EDs, individuals with BN reported higher emotional reactivity and were more likely to engage in NSSI compared to those with anorexia nervosa. Emotional reactivity was inconsistently related to treatment outcomes among the co-occurring and ED-only groups. Results highlight the importance of emotional reactivity in clinical presentation, particularly when NSSI is present.

show abstract

“…Somatic complications related to malnutrition including bradycardia, hypokaliemia, hypotension, anemia, hormonal imbalance, and osteoporosis [7] are well documented in AN. All these psychiatric and somatic complications massively impair functional capacities and quality of life [8]. The pathophysiological mechanisms of AN remain debated, but evidence is accumulating for a dysregulation of neuropeptidergic regulation of eating behavior in response to different types of stress [9,10].…”

Section: Introductionmentioning

confidence: 99%

Micronutrient Status in 153 Patients with Anorexia Nervosa

et al. 2017

View full text Add to dashboard Cite

Micronutrient status in Anorexia Nervosa (AN) has been poorly documented and previous data are often contradictory. We aimed to assess micronutrient status in a large population of AN patients. The relationships between micronutrient status and body composition were also determined. Anthropometric, biochemical parameters and body composition data were collected at referral in 153 patients with AN (28.5 ± 11 years). At least one trace element deficit was observed in almost half of patients; the most frequent was selenium deficit (40% of patients). At least one vitamin deficit was observed in 45.7% of patients, mostly vitamin A and B9. Albumin, transthyretin and CRP were within normal range in most patients. No correlations were found between body composition and micronutrient status. Our study suggests that micronutrient status is often altered in AN patients, which may contribute to neuropsychiatric dysfunction. Monitoring of micronutrients and correction of deficits should be included in the routine care of AN patients.

show abstract

A systematic review of the health-related quality of life and economic burdens of anorexia nervosa, bulimia nervosa, and binge eating disorder

Cited by 278 publications

References 88 publications

Corticotropin-Releasing Factor (CRF) and Addictive Behaviors

Corticotropin-Releasing Factor (CRF) and Addictive Behaviors

Emotional reactivity in a clinical sample of patients with eating disorders and nonsuicidal self-injury

Micronutrient Status in 153 Patients with Anorexia Nervosa

Contact Info

Product

Resources

About