A systematic review of the supportive care needs of women living with and beyond cervical cancer

Maguire, Roma; Kotronoulas, Grigorios; Simpson, Mhairi; Paterson, Catherine

doi:10.1016/j.ygyno.2014.10.030

Cited by 95 publications

(113 citation statements)

References 70 publications

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“…Cervical carcinoma is the most common type of gynaecological malignancy worldwide [57], and it is one of the leading causes of cancer death among females, especially in less developed countries [58]. In contrast to the traditional “clonal evolution” theory of carcinogenesis, which describes cervical carcinoma as a consequence of unlimited and uncontrolled cellular proliferation, there is heterogeneity in cervical carcinoma.…”

Section: Cervical Cancer Stem Cells (Ccscs)mentioning

confidence: 99%

Cancer stem cells (CSCs), cervical CSCs and targeted therapies

2016

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Accumulating evidence has shown that cancer stem cells (CSCs) have a tumour-initiating capacity and play crucial roles in tumour metastasis, relapse and chemo/radio-resistance. As tumour propagation initiators, CSCs are considered to be promising targets for obtaining a better therapeutic outcome. Cervical carcinoma is the most common gynaecological malignancy and has a high cancer mortality rate among females. As a result, the investigation of cervical cancer stem cells (CCSCs) is of great value. However, the numbers of cancer cells and corresponding CSCs in malignancy are dynamically balanced, and CSCs may reside in the CSC niche, about which little is known to date. Therefore, due to their complicated molecular phenotypes and biological behaviours, it remains challenging to obtain “purified” CSCs and continuously culture CSCs for further in vitro studies without the cells losing their stem properties. At present, CSC-related markers and functional assays are used to purify, identify and therapeutically target CSCs both in vitro and in vivo. Nevertheless, CSC-related markers are not universal to all tumour types, although some markers may be valid in multiple tumour types. Additionally, functional identifications based on CSC-specific properties are usually limited in in vivo studies. Furthermore, an optimal method for identifying potential CCSCs in CCSC studies has not been previously published, and these techniques are currently of great importance. This article updates our knowledge on CSCs and CCSCs, reviews potential stem cell markers and functional assays for identifying CCSCs, and describes the potential of targeting CCSCs in the treatment of cervical carcinoma.

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Section: Cervical Cancer Stem Cells (Ccscs)mentioning

confidence: 99%

Cancer stem cells (CSCs), cervical CSCs and targeted therapies

2016

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“…Several reviews [6][7][8][9] as well as original studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] have described the prevalence of different supportive care needs in both breast and gynecological cancer. In previous research, the need for additional medical information on the disease has been consistently reported to be highly prevalent in both breast [6,10,16,17,29] and gynecological cancer [7,9,10,12,13,16,24,25,27]. Breast and gynecological patients also expressed a wish for education on how to improve their health by changing their health behaviors [17,29].…”

Section: Introductionmentioning

confidence: 99%

Supportive care needs and quality of life in patients with breast and gynecological cancer attending inpatient rehabilitation. A prospective study

Faller

Hass²,

Engehausen³

et al. 2019

Acta Oncologica

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Background: Among patients with breast or gynecological cancer, supportive care needs are both highly prevalent and enduring. However, little is known about whether meeting patients' needs is accompanied by increased quality of life (QoL). We aimed to explore patients' supportive care needs reported at the beginning of inpatient rehabilitation and examined whether meeting these needs resulted in improved QoL. Material and methods: In a multicenter, prospective cohort study with 2 measurement occasions (beginning and end of inpatient rehabilitation), 292 patients with breast and gynecological cancer (mean age 55 years; 71% breast cancer) were enrolled. In 73%, time since diagnosis was longer than 6 months. We obtained self-reports of supportive care needs in 12 domains and measured QoL using the EORTC QLQ-C30 functioning subscales. Results: At the beginning of inpatient rehabilitation, top-ranking severe supportive care needs concerned coordination of care (48%), medical information (45%), alleviation of physical symptoms (42%) and support with improving health behaviors (36%). At the end of inpatient rehabilitation, all needs assessed declined significantly, although many patients still expressed strong needs in some domains. However, meeting patients' needs was accompanied by improvements in all functioning subscales. Conclusions: This is the first study to show that meeting breast and gynecological cancer patients' supportive care needs during inpatient rehabilitation resulted in improved QoL. Given the considerable proportions of patients still reporting unmet needs at the end of their stay, stronger and continuing efforts seem warranted to meet these needs and thus further increase QoL. ARTICLE HISTORY

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“…Yati Afiyanti, B.Sc.inf., M.Sc.inf., Département de maternité et de santé des femmes, Faculté des sciences infirmières, Université d'Indonésie, Depok, Indonésie En dépit de l'abondante littérature sur les besoins en soins de soutien et la qualité de vie, les données provenant des pays à faible et moyen revenu, tels que l'Indonésie, sont rares, et ces milieux sociodémographiques sont souvent sous-représentés dans les revues de littérature (Gonçalves, 2010;Maguire et al, 2015). En Indonésie, les femmes qui luttent contre le cancer doivent composer avec plusieurs facteurs de stress reliés à leur statut socio-économique, éducationnel et culturel défavorable (Ell et al, 2005).…”

Section: Au Sujet Des Auteuresunclassified

“…Ce type de soins implique une approche centrée sur la personne afin d'offrir les services essentiels aux personnes affectées de près ou de loin par le cancer. Les soins de soutien aident les victimes du cancer à satisfaire leurs besoins physiques, psychologiques, spirituels, sexuels, sociaux, pratiques et informationnels avant et pendant la tombée du diagnostic, durant la thérapie, et pendant la survie (Fitch, 2008;Maguire, Kotronoulas, Simpson et Paterson, 2015). Les soins de soutien visent avant tout à contrôler les symptômes et à améliorer la qualité de vie (Hui, 2014).…”

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