A Systematic Review of the Anal Fistula Plug for Patients With Crohn's and Non-Crohn's Related Fistula-in-Ano

O’Riordan, J M; Datta, Indraneel; Johnston, C.; Baxter, Nancy N.

doi:10.1097/dcr.0b013e318239d1e4

Cited by 142 publications

(104 citation statements)

References 66 publications

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“…These agents include fibrin glue,78 plugs,79 hyperosmolar glucose (50%), doxycycline80 and n-butyl-2-cyanoacrylate (Histoacryl) 81. Those agents can be administered via endoscopic procedures, as this can be technically feasible (figure 4).…”

Section: The Role Of Endoscopy In the Management Of Perianal Fistulasmentioning

confidence: 99%

“…Both outlined the scarcity of studies in the literature, as most are retrospective case series or prospective cohorts with significant heterogeneity. The first review included 20 studies and reported both CD-related and non-CD fistulas 79. Only 42 patients with were analysed, from a total of 530 included patients.…”

Section: Modern Surgical Techniques For Perianal Fistulas In CDmentioning

confidence: 99%

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Modern management of perianal fistulas in Crohn’s disease: future directions

Kotze

Shen

Lightner

et al. 2018

Gut

120

101

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Perianal fistulae in patients with Crohn's disease (CD) can be associated with significant morbidity resulting in negative impact on quality of life. The last two decades have seen significant advancements in the management of perianal fistulas in CD, which has evolved into a multidisciplinary approach that includes gastroenterologists, colorectal surgeons, endoscopists and radiologists. Despite the introduction of new medical therapies such as antitumour necrosis factor and novel models of care delivery, the best fistula healing rates reported with combined medical and surgical approaches are approximately 50%. More recently, newer biologics, cell-based therapies as well as novel endoscopic and surgical techniques have been introduced raising new hopes that outcomes can be improved upon. In this review, we describe the modern management and the most recent advances in the management of complex perianal fistulising CD, which will likely impact clinical practice. We will explore optimal use of both older and newer biological agents, as well as new data on cell-based therapies. In addition, new techniques in endoscopic and surgical approaches will be discussed.

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Section: The Role Of Endoscopy In the Management Of Perianal Fistulasmentioning

confidence: 99%

Section: Modern Surgical Techniques For Perianal Fistulas In CDmentioning

confidence: 99%

Modern management of perianal fistulas in Crohn’s disease: future directions

Kotze

Shen

Lightner

et al. 2018

Gut

120

101

View full text Add to dashboard Cite

show abstract

“…[32][33][34] A metaanalysis of 20 articles that included 42 patients with Crohn's disease reported a closure rate of 55%. 35 Collagen plugs have a promising role in high fistulas. In a recent meta-analysis of 25 studies, eight of which looked at patients with complex fistulas in a prospective fashion, the success rate for Crohn's-associated fistula in ano ranged from 29% to 86%.…”

Section: Fibrin Glue and Fistula Plugsmentioning

confidence: 99%

Perianal fistulas in patients with inflammatory bowel disease

Smith

Paulson

2014

Seminars in Colon and Rectal Surgery

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“…Insgesamt wurden die Plug-Technik und weitere neue Verfahren in diversen Reviews aufgearbeitet [82,139,214,234,292,296,332,402]. Cirocchi et al [82] …”

Section: Reviews Zur Plug-technikunclassified