A systematic review of the scales used for the measurement of cancer-related fatigue (CRF)

Minton, Ollie; Stone, Patrick

doi:10.1093/annonc/mdn537

Cited by 273 publications

(228 citation statements)

References 38 publications

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“…It is frequently suggested in the literature that fatigue is multi-dimensional and includes physical, mental and sometimes emotional components [45][46][47][48][49]. Although, the qualitative research reported here supported this multidimensional view, the correlation and factor analysis data suggested that these components are so closely related that a measure focusing on the core "symptom" of fatigue is most appropriate.…”

Section: Discussioncontrasting

confidence: 53%

Validation of the Daily Diary of Fatigue Symptoms—Fibromyalgia (DFS-Fibro)

Burbridge¹,

Symonds²,

Humphrey³

et al. 2013

OJRA

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Introduction: Fatigue is an important fibromyalgia (FM) symptom, but existing measures of fatigue are unlikely to meet regulatory standards for clinical trial use. We describe the development and validation of the Daily Diary of Fatigue Symptoms-Fibromyalgia (DFS-Fibro), a 24-hour recall, patient-reported outcome (PRO) measure of fatigue in FM that is administered electronically (ePRO). Methods: There were 3 phases of work: 1) item generation based on concept elicitation interviews with FM patients, with clinical relevance confirmed by expert clinician review; 2) pilot testing/cognitive debriefing interviews with FM patients; and 3) psychometric validation using data from a methodology study with 145 FM patients. The measure was finalised based on both qualitative and quantitative findings. Results: Twenty-three items were generated in phase 1, some minor revisions were made following the pilot testing and cognitive debriefing (phase 2) but none were deleted. All patients found the measure easy to understand and use. Item reduction was conducted taking into account both the initial psychometric data and the earlier qualitative research, resulting in a final 5 item measure of the "symptom" of fatigue. The 5-item DFS-Fibro had very high internal consistency (alpha = 0.99), and strong test-re-test reliability (r > 0.84), convergent validity and known-groups validity. Conclusion: The DFS-Fibro has strong psychometric properties and strong face and content validity for the measurement of fatigue in FM.

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Section: Discussioncontrasting

confidence: 53%

Validation of the Daily Diary of Fatigue Symptoms—Fibromyalgia (DFS-Fibro)

Burbridge¹,

Symonds²,

Humphrey³

et al. 2013

OJRA

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“…The present systematic review complements two previously published meta-analyses evaluating the effects of pharmacologic agents on fatigue in cancer patients 18,152 . Our review adds important insights, given that the review by Mustian et al 18 reported many types of interventions, citing 14 studies of pharmacologic interventions that were analyzed as a single group.…”

Section: Discussionmentioning

confidence: 72%

Pharmacologic Interventions for Fatigue in Cancer and Transplantation: A Meta-Analysis

et al. 2018

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“…52 'Fatigue' is a patient-reported outcome and multi-faceted concept including both mental and physical components whose critical domains have not been sufficiently standardized and for which several scales have been developed. 53 Despite these shortcomings, we believe that further investigation of this extremely debilitating symptom observed in many if not all cancer patients is useful for optimizing patient care.…”

confidence: 99%

Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome

et al. 2012

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Myelodysplastic syndromes and acute myeloid leukemia exemplify the complexity of treatment allocation in older patients as options range from best supportive care, non-intensive treatment (e.g. hypomethylating agents) to intensive chemotherapy/hematopoietic cell transplantation. Novel metrics for non-disease variables are urgently needed to help define the best treatment for each older patient. We investigated the feasibility and prognostic value of geriatric/quality of life assessments aside from established disease-specific variables in 195 patients aged 60 years or over with myelodysplastic syndromes/acute myeloid leukemia. These patients were grouped according to treatment intensity and assessed. Assessment consisted of eight instruments evaluating activities of daily living, depression, mental functioning, mobility, comorbidities, Karnofsky Index and quality of life. Patients with a median age of 71 years (range 60-87 years) with myelodysplastic syndromes (n=63) or acute myeloid leukemia (n=132) were treated either with best supportive care (n=47), hypomethylating agents (n=73) or intensive chemotherapy/hematopoietic cell transplantation (n=75). After selection of variables, pathological activities of daily living and quality of life/fatigue remained highly predictive for overall survival in the entire patient group beyond disease-related risk factors adverse cytogenetics and blast count of 20% or over. In 107 patients treated non-intensively activities of daily living of less than 100 (hazard ratio, HR 2.94), Karnofsky Index below 80 (HR 2.34) and quality of life/'fatigue' of 50 or over (HR 1.77) were significant prognosticators. Summation of adverse features revealed a high risk of death (HR 9.36). In-depth evaluation of older patients prior to individual treatment allocation is feasible and provides additional information to standard assessment. Patients aged 60 years or over with newly diagnosed myelodysplastic syndromes/acute myeloid leukemia and impairments in activities of daily living, Karnofsky Index below 80%, quality of life/'fatigue' of 50 or over, are likely to have poor outcomes.Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome

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A systematic review of the scales used for the measurement of cancer-related fatigue (CRF)

Cited by 273 publications

References 38 publications

Validation of the Daily Diary of Fatigue Symptoms—Fibromyalgia (DFS-Fibro)

Validation of the Daily Diary of Fatigue Symptoms—Fibromyalgia (DFS-Fibro)

Pharmacologic Interventions for Fatigue in Cancer and Transplantation: A Meta-Analysis

Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome

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