A systematic review of task-based functional neuroimaging studies investigating language, semantic and executive processes in thought disorder

Sumner, Philip; Bell, Imogen; Rossell, Susan L.

doi:10.1016/j.neubiorev.2018.08.005

Cited by 32 publications

(31 citation statements)

References 184 publications

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“…Furthermore, the present study is in line with the recent mCCA + jICA study by Lottman and colleagues (Lottman et al, ), once again highlighting the relationship between GMV alterations and aberrant INA in SSD. In particular, the aberrant interrelationships between GMV and INA might contribute to the explanation of very heterogeneous symptoms in SSD patients (Kubera et al, ; Sumner, Bell, & Rossell, , ).…”

Section: Discussionmentioning

confidence: 99%

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Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Hirjak

Rashidi

Fritze

et al. 2019

Human Brain Mapping

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Neurological soft signs (NSS) comprise a broad range of subtle neurological deficits and are considered to represent external markers of sensorimotor dysfunction frequently found in mental disorders of presumed neurodevelopmental origin. Although NSS frequently occur in schizophrenia spectrum disorders (SSD), specific patterns of co‐altered brain structure and function underlying NSS in SSD have not been investigated so far. It is unclear whether gray matter volume (GMV) alterations or aberrant brain activity or a combination of both, are associated with NSS in SSD. Here, 37 right‐handed SSD patients and 37 matched healthy controls underwent motor assessment and magnetic resonance imaging (MRI) at 3 T. NSS were examined on the Heidelberg NSS scale. We used a multivariate data fusion technique for multimodal MRI data—multiset canonical correlation and joint independent component analysis (mCCA + jICA)—to investigate co‐altered patterns of GMV and intrinsic neural fluctuations (INF) in SSD patients exhibiting NSS. The mCCA + jICA model indicated two joint group‐discriminating components (temporoparietal/cortical sensorimotor and frontocerebellar/frontoparietal networks) and one modality‐specific group‐discriminating component (p < .05, FDR corrected). NSS motor score was associated with joint frontocerebellar/frontoparietal networks in SSD patients. This study highlights complex neural pathomechanisms underlying NSS in SSD suggesting aberrant structure and function, predominantly in cortical and cerebellar systems that critically subserve sensorimotor dynamics and psychomotor organization.

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Section: Discussionmentioning

confidence: 99%

“…In particular, the aberrant interrelationships between GMV and INA might contribute to the explanation of very heterogeneous symptoms in SSD patients Sumner, Bell, & Rossell, 2018a, 2018b.…”

Section: Group Differencesmentioning

confidence: 99%

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Hirjak

Rashidi

Fritze

et al. 2019

Human Brain Mapping

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“…It is worth noting that the extant literature implicating language regions in thought disorder sought changes in language network a priori, rather than taking a discovery approach without task constraints. [19] and [20] could identify only 2 resting state fMRI studies investigating this issue, despite their exhaustive search. Interestingly, these few whole brain studies have reported sensorimotor dysconnectivity in association with thought disorder.…”

Section: Discussionmentioning

confidence: 99%

“…A large body of neuroimaging literature has attempted to parse the brain regions implicated in the thought disorders of schizophrenia [18], with several comprehensive systematic reviews [15,18,19] providing an excellent overview of the reported brain correlates of conceptual disorganization (more specifically, FTD). These reviews indicate that a large number of studies have focused explicitly on aberrations in language processing brain regions (especially superior temporal gyrus) as the major structural and functional underpinnings of FTD [20,21]. Nevertheless, null findings as well as findings that implicate brain regions that are not considered to be a part of the language network are also reported [20].…”

Section: Introductionmentioning

confidence: 99%

“…These reviews indicate that a large number of studies have focused explicitly on aberrations in language processing brain regions (especially superior temporal gyrus) as the major structural and functional underpinnings of FTD [20,21]. Nevertheless, null findings as well as findings that implicate brain regions that are not considered to be a part of the language network are also reported [20]. A notable lack of studies directly relating network-level functional connectivity to disorganization has been highlighted [19].…”

Section: Introductionmentioning

confidence: 99%

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Conceptual disorganization and redistribution of resting state cortical hubs in untreated first episode psychosis: A 7T MRI study

Dey¹,

Dempster²,

Mackinley³

et al. 2020

Preprint

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Background:Network level dysconnectivity has been studied in positive and negative symptoms of schizophrenia. Conceptual disorganization (CD) is a symptom subtype which predicts impaired real-world functioning in psychosis. Systematic reviews have reported aberrant connectivity in formal thought disorder, a construct related to CD. However, no studies have investigated whole-brain functional correlates of CD in psychosis. We sought to investigate brain regions explaining the severity of CD in patients with first-episode psychosis (FEPs) compared with healthy controls (HCs).Methods:We computed whole-brain binarized degree centrality maps of 31 FEPs, 25 HCs and characterized the patterns of network connectivity in the two groups. In FEPs, we related these findings to the severity of CD. We also studied the effect of positive and negative symptoms on altered network connectivity.Results:Compared to HCs, reduced hubness of a right superior temporal gyrus (rSTG) cluster was observed in the FEPs. In patients exhibiting high CD, increased hubness of a medial superior parietal (mSPL) cluster was observed, compared to patients exhibiting low CD. These two regions were strongly correlated with CD scores but not with other symptom scores.Discussion:Our observations are congruent with previous findings of reduced but not increased hubness. We observed increased hubness of mSPL suggesting that cortical reorganization occurs to provide alternate routes for information transfer.Conclusion:These findings provide insight into the underlying neural processes mediating the presentation of symptoms in untreated FEP. A longitudinal tracking of the symptom course will be useful to assess the mechanisms underlying these compensatory changes.

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The Experience of People with Formal Thought Disorder

Barrera

2020

Theory and History in the Human and Social Sciences

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A systematic review of task-based functional neuroimaging studies investigating language, semantic and executive processes in thought disorder

Cited by 32 publications

References 184 publications

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Conceptual disorganization and redistribution of resting state cortical hubs in untreated first episode psychosis: A 7T MRI study

The Experience of People with Formal Thought Disorder

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