A systematic review of severe morbidity in infants born late preterm

Teune, Margreet J.; Bakhuizen, Sabine; Bannerman, Cynthia Gyamfi; Opmeer, Brent C.; Kaam, Anton H. van; Wassenaer, Aleid G. van; Morris, Jonathan M.; Mol, Ben W J

doi:10.1016/j.ajog.2011.07.015

Cited by 298 publications

(254 citation statements)

References 40 publications

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“…Pediatrics 2012;130:e265-e272 3 These neonatal morbidities include asphyxia, respiratory insufficiency, circulatory insufficiency, septicemia, hypoglycemia, hyperbilirubinemia, apnea, hypothermia, and feeding problems. [3][4][5][6] Some of these morbidities are severe enough to warrant admission to a tertiary NICU. Apart from the risk of neonatal morbidities, moderately preterm-born children are also more likely to have developmental delays at preschool age.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Morbidities and Developmental Delay in Moderately Preterm-Born Children

et al. 2012

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BACKGROUND AND OBJECTIVE: Children born moderately preterm (32–356/7 weeks’ gestation) are at increased risk of both neonatal morbidities and developmental delays in early childhood. It is unknown whether neonatal morbidities contribute to the increased risk of developmental delay. The objective of this study was to determine the effect of neonatal morbidities after moderately preterm birth on development at preschool age. METHODS: In a community-based, stratified cohort, parents of 832 moderately preterm children born in 2002 or 2003 completed the Ages and Stage Questionnaire when their child was 43 to 49 months old. Data on Apgar scores, asphyxia, tertiary NICU admission, hospital transfer, circulatory insufficiency, hypoglycemia, septicemia, mechanical ventilation, continuous positive airway pressure, apneas, caffeine treatment, and hyperbilirubinemia were obtained from medical records. We assessed associations of neonatal characteristics with developmental delay, adjusted for gender, small-for-gestational-age status, gestational age, and maternal education. RESULTS: Hypoglycemia and asphyxia were associated with developmental delay; odds ratios (ORs) were 2.42 (95% confidence interval [CI]: 1.23–4.77) and 3.18 (95% CI: 1.01–10.0), respectively. Tertiary NICU admission and hyperbilirubinemia had positive but statistically borderline nonsignificant associations with developmental delay: ORs were 1.74 (95% CI: 0.96–3.15) and 1.52 (95% CI: 0.94–2.46), respectively. No other neonatal morbidities were associated with developmental delay. In multivariate analyses, only hypoglycemia was associated with developmental delay (OR: 2.19; 95% CI: 1.08–4.46). CONCLUSIONS: In moderately preterm-born children, only hypoglycemia increased the risk of developmental delay at preschool age. A concerted effort to prevent hypoglycemia might enhance developmental outcome in this group.

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Section: Discussionmentioning

confidence: 99%

Neonatal Morbidities and Developmental Delay in Moderately Preterm-Born Children

et al. 2012

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“…11 Recommendations for immediate delivery following preterm ruptured membranes close to term require grounding in good clinical evidence as even mild prematurity is associated with a significant health burden both in the short and long term. 12 We undertook an international multicentre randomized controlled trial to establish the optimal management of birth following preterm premature rupture of the membranes close to term (PPROMT): comparing immediate delivery with expectant management, the PPROMT Trial (ISRCTN44485060)…”

Section: Aimsmentioning

confidence: 99%

Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial

et al. 2016

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A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.For more information, please contact eprints@nottingham.ac.uk 1 Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term

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“…The proportion of late preterm births has markedly increased during the past two decades, accounting for 70% of preterm births (1). Late preterm infants have been recognized as a high-risk group of infants as they present unique physiology and greater risks in terms of mortality and morbidity as compared with full-term infants (2,3).…”

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confidence: 99%

Postnatal catch-up fat after late preterm birth

et al. 2012

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Background: Late preterm birth accounts for 70% of preterm births. The aim of the study was to investigate the postnatal weight gain and weight gain composition changes in a cohort of late preterm infants. Methods: a total of 49 late preterm infants (mean birth weight 2,496 ± 330 g and gestational age 35.2 ± 0.7 wks) underwent growth and body composition assessment by an air displacement plethysmography system on the fifth day of life, at term, and at 1 and 3 mo of corrected age. The reference group was composed of 40 healthy, full-term, breast-fed infants. results: The late preterm infants showed a Δ fat mass gain between birth and term-corrected age equal to 182%. as compared with full-term infants, at term and 1 mo of corrected age mean weight (3,396 ± 390 vs. 3,074 ± 409 g and 4,521 ± 398 vs. 4,235 ± 673 g, respectively) and percentage of fat mass (16.1 ± 4.6 vs. 8.9 ± 2.9 and 22.6 ± 4.2 vs. 17.4 ± 4.0, respectively) were significantly higher in late preterm infants, whereas no difference among groups was found at 3 mo. conclusion: Rapid postnatal catch-up fat was found in these infants. Further studies are needed to investigate whether this short-term increase in fat mass may modulate the risk of chronic diseases or represent an adaptive mechanism to extrauterine life.

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A systematic review of severe morbidity in infants born late preterm

Cited by 298 publications

References 40 publications

Neonatal Morbidities and Developmental Delay in Moderately Preterm-Born Children

Neonatal Morbidities and Developmental Delay in Moderately Preterm-Born Children

Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial

Postnatal catch-up fat after late preterm birth

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