A Systematic Review of Prognostic Tools for Stroke in Patients with Diabetes

Chowdhury, Mohammad Shah Jahirul Hoque; Yeasmin, Fahmida; Chowdhury, Tanvir Turin

doi:10.1016/j.jcjd.2017.08.231

Cited by 1 publication

(3 citation statements)

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“…Estimates from 1997 suggested that worldwide, about five percent (5%) of all heterosexual couples had unresolved infertility (Himmel [2]). Male infertility constitutes about 20% -30% of infertility cases, while 20% -35% are due to female infertility and 25% -40% are due to combined problems in both sexes (Chowdhury [1]). There are basically two types of infertility: primary and secondary.…”

Section: Introductionmentioning

confidence: 99%

“…Other causes which have been implicated are infections, Cushing's syndrome, hyperprolactinaemia, thyroid disorders, Polycystic Ovary Syndrome (PCOS), and Primary Ovarian Insufficiency (POI) (Michael [4,5]). Furthermore, ovulatory problems which generally manifest with sparse or absent menstrual periods have been implicated as one of the major causes of infertility among women (Chowdhury [1]). Metabolic processes in humans result in the generation of Reactive Oxygen Species (ROS).…”

Section: Introductionmentioning

confidence: 99%

“…Antioxidants are probably now regarded as superheroes for maintaining health. The enzymatic antioxidants such as Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidases (GPx), and non-enzymatic antioxidants like Vitamin C, Vitamin E, Ceruloplasmin, albumin, and reduced glutathione (GSH) play important roles in the protection of cells against free radical damage (Halliwel [1,6,7]). Excessive generation of ROS, higher than the supply of antioxidants to the body system, results in oxidative stress (OS).…”

Section: Introductionmentioning

confidence: 99%

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"Effect of Supplementation with Moringa Oleifera on Antioxidant and Oxidative Stress Biomarkers of Infertile Women: A Pilot Open-Label Case-Control Randomized Clinical Study"

Onyeaghala

2024

BJSTR

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Background: Excessive generation of free radicals has been reported to be associated with infertility. Clinical studies investigating the effect of supplementation with moringa oleifera on antioxidant and oxidative stress markers of infertile women are depleted. This study aims to investigate the effects of supplementation with Moringa Oleifera on the antioxidant and oxidative stress markers of infertile women. Methodology:This study was an open-label case-control randomized clinical study. A total of 100 women, aged 35-50 years, attending Island Maternity Hospital, Lagos, and diagnosed with infertility were recruited and screened. Pre-enrollment fertility screening for LH, FSH, Prolactin, and E2 was measured using the ELISA technique. Of these numbers, 40 had elevated reproductive hormones and were excluded. Sixty (60) of these infertile women with normal hormone levels were randomized into two groups -cases and controls, each comprising 30 subjects respectively. Thirty (30) fertile women were recruited for comparison of the baselines of biomarkers between fertile and infertile women. A five-milliliter (5ml) blood sample was collected and used to assess the baseline parameters. The case group was supplemented with 2g of Moringa capsules daily for four weeks. The control group received no supplementation. After four weeks post-supplementation, Plasma levels of Malondialdehyde (MDA), Total Plasma Peroxide (TPP), Lipid hydroperoxide (LPO), Total Antioxidant Capacity (TAC), Glutathione reductase (GR), and Glutathione (GSH) were reassessed using standard methods. The Oxidative Stress Index (OSI) was calculated using an approved conventional method. Results:The mean levels of markers of oxidative stress (MDA, TPP, LPO, and OSI) were higher in infertile women than in the fertile group. However, only TPP and OSI were significantly higher (p ≤ 0.05). Levels of MDA, TPP, LPO, and OSI were lower in the supplemented group than in those unsupplemented (P>0.05). The levels of antioxidant biomarkers (TAC, GR, and GSH) were slightly higher in the infertile women supplemented with Moringa Oleifera than in the unsupplemented group (P>0.05). Conclusion:This study revealed that an increase in oxidative stress biomarkers is associated with female infertility. Supplementation with moringer oleifera in infertile women could help reduce the effects of OS and may likely improve pregnancy outcomes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%