A systematic review of persistence and compliance with bisphosphonates for osteoporosis

Abstract

Although patients using weekly bisphosphonate medication follow their prescribed dosing regimens better than those using daily therapy, overall compliance and persistence rates were suboptimal.

Cost Effectiveness of Denosumab Compared with Oral Bisphosphonates in the Treatment of Post-Menopausal Osteoporotic Women in Belgium

“…However, it has been shown that the mode and schedule of administration may affect persistence and compliance with therapy and, in particular, less frequent regimens have been associated with better adherence. [16,63] Therefore, persistence rates for twice-yearly injections of denosumab would be higher than those previously reported for daily or weekly bisphosphonates. This has been recently confirmed by an open-label study of 250 osteoporotic women who were randomized to either denosumab or branded oral alendronate.…”

Osteoporosis: recent advances in diagnosis and management

“…9 In the UK there is a move towards adopting 20 per cent risk for any osteoporotic fracture and 5 per cent for hip fracture. Fixed treatment thresholds for people in the UK are attractive as they are easy to use and allow clear division into low risk (less than 10 per cent for any fracture and 3 per cent for hip fracture), intermediate risk (10)(11)(12)(13)(14)(15)(16)(17)(18)(19) per cent for any fracture and 3-5 per cent for hip fracture) and high risk (>20 per cent for any and >5 per cent for hip fracture). In the absence of national guidance, the decision as to which treatment threshold to use needs to be agreed locally.…”

“…Adherence to oral medications to reduce fracture risk is generally poor, with approximately one-third to a half of people prescribed bisphosphonates having low or nonadherence. 16 This poor adherence is associated with an increased risk of fracture 17 and compliance should be reviewed at each encounter, with efforts made to find more acceptable agents where necessary, such as parenteral agents.…”

Osteoporoz Tedavisine Yetersiz Yanıt

“…Uyum eksikliği tüm tedavilerde önemli bir konudur; kronik hastalıklar ve OP bir istisna değildir. Osteoporotik hastalarda bir yıllık tedavide hastaların uyum oranları %26 ile %70 arasında değişmektedir (32). Tamamen veya neredeyse tamamen uyumlu hastalarla karşılaştırıldığında, uyum eksikliğinin kırık riskinde artışı ile ilişkili olduğu gösterilmiştir (33,34).…”