A Systematic Review of Outcomes Following Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)

Sharma, Kavita; Gilmour, Adam; Jones, Georgina; O’Donoghue, J.M.; Clemens, Mark W.

doi:10.1016/j.jpra.2022.08.008

Cited by 10 publications

(22 citation statements)

References 17 publications

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“…The most common BIA-ALCL presentation consists of painless swelling of the breast and late-onset seroma. A minority of patients presents with a palpable mass in the breast [ 68 , 69 ]. Other signs and symptoms may be present, such as capsular contracture, local pain, lymphadenopathy and B-symptoms [ 6 , 68 , 69 ].…”

Section: Implications For Clinical Practicementioning

confidence: 99%

“…A minority of patients presents with a palpable mass in the breast [ 68 , 69 ]. Other signs and symptoms may be present, such as capsular contracture, local pain, lymphadenopathy and B-symptoms [ 6 , 68 , 69 ]. Patients who had implants placed for cosmetic augmentation and those who underwent implant-based reconstruction showed no difference in both incidence and clinical presentation [ 33 ].…”

Section: Implications For Clinical Practicementioning

confidence: 99%

“…Patients who had implants placed for cosmetic augmentation and those who underwent implant-based reconstruction showed no difference in both incidence and clinical presentation [ 33 ]. A systemic review by Sharma and et al reported that 82% of patients presented with swelling in the breast and breast asymmetry, 10% with pain and 8% with palpable breast mass [ 69 ]. Less frequent presentations of BIA-ALCL include regional lymphadenopathy, local skin rash, fever and capsular contracture [ 7 , 70 ].…”

Section: Implications For Clinical Practicementioning

confidence: 99%

“…BIA-ALCL’s clinical behavior resembles more solid tumors than other non-Hodgkin lymphomas. Therefore, the MD Anderson Cancer Center TNM developed a more appropriate staging system which replaced the Ann Arbor classification for non-Hodgkin lymphomas [ 69 , 72 ].…”

Section: Implications For Clinical Practicementioning

confidence: 99%

“…Although most of the data on treatment and outcomes come from retrospective case series and reports, factors associated with higher risk of recurrence and mortality include presentation with a mass, advanced stage at presentation, extracapsular involvement and incomplete surgery [ 33 , 68 , 69 ]. Complete surgery is defined as breast implant removal and total capsulectomy with complete excision of any associated mass and negative margins on final pathologic evaluation [ 6 ].…”

Section: Implications For Clinical Practicementioning

confidence: 99%

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The Role of Microorganisms in the Development of Breast Implant-Associated Anaplastic Large Cell Lymphoma

et al. 2023

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Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a variant of anaplastic large cell lymphoma (ALCL) associated with textured-surface silicone breast implants. Since first being described in 1997, over 1100 cases have been currently reported worldwide. A causal relationship between BIA-ALCL and textured implants has been established in epidemiological studies, but a multifactorial process is likely to be involved in the pathogenesis of BIA-ALCL. However, pathophysiologic mechanisms remain unclear. One of the hypotheses that could explain the link between textured implants and BIA-ALCL consists in the greater tendency of bacterial biofilm in colonizing the surface of textured implants compared to smooth implants, and the resulting chronic inflammation which, in predisposed individuals, may lead to tumorigenesis. This review summarizes the existing evidence on the role of micro-organisms and rough surface implants in the development of BIA-ALCL. It also provides insights into the most updated clinical practice knowledge about BIA-ALCL, from clinical presentation and investigation to treatment and outcomes.

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Section: Implications For Clinical Practicementioning

confidence: 99%

Section: Implications For Clinical Practicementioning

confidence: 99%

Section: Implications For Clinical Practicementioning

confidence: 99%

Section: Implications For Clinical Practicementioning

confidence: 99%

Section: Implications For Clinical Practicementioning

confidence: 99%

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The Role of Microorganisms in the Development of Breast Implant-Associated Anaplastic Large Cell Lymphoma

et al. 2023

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The Risk of Breast Implant-Associated Anaplastic Large Cell Lymphoma; A Systematic Review and Meta-Analysis

Elameen,

AlMarakby,

Atta

et al. 2024

Aesth Plast Surg

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Background Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an emerging disorder that has gained global attention throughout the past era. The present meta-analysis was performed to retrieve the risk of BIA-ALCL from population-based epidemiological studies. Factors associated with BIA-ALCL were evaluated to identify patients at higher risk of BIA-ALCL. Methods A systematic literature search was executed throughout 12 databases. All epidemiological studies encompassing patients with breast implants either for aesthetic or reconstructive purposes and reported the risk of BIA-ALCL were included. Studies reported the risk factors of BIA-ALCL were included. Results The present meta-analysis included 17 articles, encompassing 525,475 patients with breast implants. There were 254 patients with BIA-ALCL with a mean duration to the diagnosis of BIA-ALCL of 13.16 years (95% CI 11.7–14.6, P < 0.001). There were 44 patients with textured breast implants and two with smooth implants. Patients with breast implants were 28.86 times more at high risk of BI-ALCL (95% CI 3.123–266.681). The risk ranged from 0 to 1 per 1000 cases with breast implants, with a similar risk among patients seeking aesthetic and reconstructive surgeries. The risk was 0 to 1 case per 1000 cases among patients with textured breast implants. There was a significant association between the history of breast cancer and BIA-ALCL (P = 0.0016). Conclusion This meta-analysis confirmed the association between breast implants and ALCL. There was a similar risk of BIA-ALCL among patients with aesthetic or reconstructive surgeries. Patients with a history of breast cancer were at higher risk of BIA-ALCL. Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Breast Implant-Associated Anaplastic Large Cell Lymphoma: Where Hematology and Plastic Surgery Meet

Joks,

Czernikiewicz,

Mazurkiewicz

et al. 2024

Clinical Lymphoma Myeloma and Leukemia

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A Systematic Review of Outcomes Following Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)

Cited by 10 publications

References 17 publications

The Role of Microorganisms in the Development of Breast Implant-Associated Anaplastic Large Cell Lymphoma

The Role of Microorganisms in the Development of Breast Implant-Associated Anaplastic Large Cell Lymphoma

The Risk of Breast Implant-Associated Anaplastic Large Cell Lymphoma; A Systematic Review and Meta-Analysis

Breast Implant-Associated Anaplastic Large Cell Lymphoma: Where Hematology and Plastic Surgery Meet

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