A systematic review of integrative clinical trials for supportive care in pediatric oncology: a report from the International Society of Pediatric Oncology, T&amp;CM collaborative

Radossi, Andrea L.; Taromina, Katherine; Marjerrison, Stacey; Diorio, Caroline; Similio, Raquel; Njuguna, Festus; Afungchwi, Glenn Mbah; Ladas, Elena J.

doi:10.1007/s00520-017-3908-0

Cited by 27 publications

(30 citation statements)

References 59 publications

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“…There have been several studies evaluating the efficacy of massage therapy in the setting of pediatric oncology. 36 The available evidence suggests that massage therapy may be beneficial for several symptoms, which concurs with a recent consensus statement on nonpharmacologic approaches. 79 Evidence-based nonpharmacologic massage therapy may be a cost-effective approach to advance the provision of supportive care throughout the spectrum of pediatric cancer care.…”

Section: Massagesupporting

confidence: 80%

“…A recent systematic review of clinical trials evaluating the use of nutritional supplements for supportive care indications found several studies with a range of evidence. 36 The authors reported on 32 studies that investigated the use of dietary supplements for several supportive care indications, including mucositis (N = 12), [37][38][39][40][41][42][43][44][45][46][47][48] treatment-related toxicities (N = 5), [49][50][51][52][53] appetite and weight management (N = 3), [54][55][56] hepatic toxicity (N = 3), [57][58][59] fever and neutropenia (N = 3), [60][61][62] neuropathy (N = 2), 63,64 chemotherapyinduced nausea and vomiting (N = 2), 65,66 bone mineral density (N = 1), 67 and gastrointestinal symptoms (N = 1). 68 Mixed, but encouraging, findings were reported for glutamine and honey for mucositits, zinc for the prevention of weight loss and infections, essential fatty acids for weight loss, and milk thistle for the treatment of hepatoxicity.…”

Section: Nutritional Supplementsmentioning

confidence: 99%

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Integrative Medicine in Childhood Cancer

Ladas

2018

The Journal of Alternative and Complementary Medicine

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The diagnosis of cancer in a child leaves parents and families devastated and vulnerable. In an effort to do everything possible, families often choose an integrative medicine approach to their child's care. Surveys have found that 31%-84% of children with cancer use complementary and alternative medicine and most often as supportive care agents. Several systematic reviews have demonstrated a clinical benefit for some select therapies; however, the safety and efficacy of the combination of biological therapies with conventional treatment remain largely unknown and garner concern due to the potential for interactions with conventional therapy. Given the sustained use and potential benefit of integrative medicine, additional research is warranted in pediatric oncology. Utilizing the available literature, clinical providers should aim to conduct open and nonjudgmental discussions with families about the use of integrative medicine so as to guide the safe integration of the two modalities.

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Section: Massagesupporting

confidence: 80%

Section: Nutritional Supplementsmentioning

confidence: 99%

Integrative Medicine in Childhood Cancer

Ladas

2018

The Journal of Alternative and Complementary Medicine

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“…Many of these approaches may not be evidence-based due to the difficulty of standardizing the products used and approaches or techniques employed. These impending trends underscore the need for effective models of integrative care that are both evidence-based and culturally sensitive [ 111 , 112 ]. Further research work evaluating the use of CAM among survivors of childhood cancer may help clarify and answer the many questions and concerns regarding the use of complementary and conventional therapy and better delineate its role in health care needs of childhood cancer survivors.…”

Section: Directions For Future Researchmentioning

confidence: 99%

Clinical ascertainment of health outcomes in Asian survivors of childhood cancer: a systematic review

Poon

Peng

et al. 2019

J Cancer Surviv

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Purpose Survivorship in children with cancer comes at a cost of developing chronic treatment-related complications. Yet, it is still an under-researched area in Asia, which shares the largest proportion of the global childhood cancer burden given its vast population. This systematic review summarizes existing literature on clinically ascertained health outcomes in Asian survivors of childhood cancer. Methods A search was conducted on Ovid Medline and EMBASE for studies that focused on survivors of childhood cancer from countries in East and Southeast Asia; adopted post-treatment clinical ascertainment of organ-specific toxicities or/and secondary malignancy. Studies were excluded if health outcomes were assessed during the acute treatment. Results Fifty-nine studies, enrolling a total of 13,442 subjects, were conducted on survivors of leukemia (34%), CNS tumor (14%), and cohorts of survivors with heterogeneous cancer diagnoses (52%). The studies used different medical evaluation methods to assess cardiovascular (15%), metabolic and infertility (32%), and neurological/neurocognitive (20%) outcomes in survivors. The collective findings suggest potential differences in the prevalence of certain late effects (e.g., secondary malignancy and obesity) among Asian and non-Asian populations, which may reflect differences in treatment regimens, practice, genetic variations, or/and socioeconomic disparity. Conclusions We recommend developing collaborative initiatives to build a regional repository of systematically assessed health outcomes and biospecimens to investigate treatment, social-environmental and genetic predictors, and interventions for late effects in this population. Implications for Cancer Survivors The existing types of chronic health problems identified in this review suggest the need for active screening, better access to survivorship care, and promotion of protective health behavior in Asia. Keywords Childhood cancer. Late effects. Survivorship. Risk-based. Asian. Organ toxicity The review was presented at the 8th Nursing Symposium on Cancer Care, Hong Kong (24th to 25th May), and was awarded the Best Poster Award.

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“… 4 , 13 , 14 Pediatric oncology programs may offer a variety of nonpharmacological interventions, including acupuncture, aromatherapy, massage, music therapy, and supplements, as part of their standard of care. 15 The contemporary literature base suggests that nonpharmacological interventions, such as music therapy, may lessen emotional and somatic distress post BMT. 1 , 2 , 8 , 16 …”

Section: Literature Reviewmentioning

confidence: 99%

Caregiver Perceptions of Music Therapy for Children Hospitalized for a Blood and Marrow Transplant: An Interpretivist Investigation

Yates

Beckmann

Voss

et al. 2018

Glob Adv Health Med

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BackgroundDespite pharmacological and psychosocial support, pediatric blood and marrow transplant (BMT) recipients typically experience heightened levels of somatic and psychological distress while undergoing transplant. Although clinicians have used psychosocial interventions to target distress, there are gaps in the literature concerning music therapy for children recovering from BMT. This is especially the case among younger children and those affected by rare genetic or metabolic disorders.ObjectiveAs caregivers are the primary decision makers for minor children, there is a need to understand their preferences and values as this constitutes a component of evidence-informed practice. Therefore, the purpose of this interpretivist investigation was to explore primary caregivers’ perspectives and experiences with music therapy for their children during hospitalization for BMT.MethodsThe researchers conducted semistructured phone interviews with 15 primary caregivers of children who had received music therapy services while hospitalized for BMT. Member checking was used to ensure accuracy of the transcripts and experiences, while trustworthiness was used to verify themes.ResultsFifteen caregivers of 14 pediatric BMT recipients were interviewed by phone. The following four themes emerged: (1) music therapy motivated patients to physically engage their bodies despite symptoms; (2) music therapy elevated patients’ moods; (3) caregivers benefited from seeing their child engaged in music therapy; and (4) caregivers were appreciative for the opportunity and requested additional music therapy services.ConclusionsCaregivers perceived music therapy to be a positive and beneficial experience for pediatric patients while hospitalized for BMT. Implications for clinical practice, limitations, and suggestions for future research are provided.

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A systematic review of integrative clinical trials for supportive care in pediatric oncology: a report from the International Society of Pediatric Oncology, T&CM collaborative

Cited by 27 publications

References 59 publications

Integrative Medicine in Childhood Cancer

Integrative Medicine in Childhood Cancer

Clinical ascertainment of health outcomes in Asian survivors of childhood cancer: a systematic review

Caregiver Perceptions of Music Therapy for Children Hospitalized for a Blood and Marrow Transplant: An Interpretivist Investigation

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