A systematic review of influenza virus in water environments across human, poultry, and wild bird habitats

Kenmoe, S; Takuissu, GR; Ebogo-Belobo, JT; Kengne-Ndé, C; Mbaga, DS; Bowo-Ngandji, A; Ondigui Ndzie, JL; Kenfack-Momo, R; Tchatchouang, S; Lontuo Fogang, R; Zeuko'o Menkem, E; Kame-Ngasse, GI; Magoudjou-Pekam, JN; Puzelli, S; Lucentini, L; Veneri, C; Mancini, P; Bonanno Ferraro, G; Iaconelli, M; Del Giudice, C; Brandtner, D; Suffredini, E; La Rosa, G

doi:10.1016/j.wroa.2023.100210

Cited by 4 publications

(1 citation statement)

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“…Influenza viruses are known for their global distribution and high infection rate among high-risk groups, resulting in a strong recommendation for vaccination in this subset of the population [1][2][3]. Some influenza strains can be zoonotic and transmitted to people [4].…”

Section: Introductionmentioning

confidence: 99%

A Computationally Optimized Broadly Reactive Hemagglutinin and Neuraminidase Vaccine Boosts Antibody-Secreting Cells and Induces a Robust Serological Response, Preventing Lung Damage in a Pre-Immune Model

Ge,

Mota,

Richardson

et al. 2024

Vaccines

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The hemagglutinin (HA) and neuraminidase (NA) surface proteins are the primary and secondary immune targets for most influenza vaccines. In this study, H2, H5, H7, N1, and N2 antigens designed by the computationally optimized broadly reactive antigen (COBRA) methodology were incorporated into an adjuvant-formulated vaccine to assess the protective efficacy and immune response against A/Hong Kong/125/2017 H7N9 virus challenge in pre-immune mice. The elicited antibodies bound to H2, H5, H7, N1, and N2 wild-type antigens; cH6/1 antigens; and cH7/3 antigens, with hemagglutinin inhibition (HAI) activity against broad panels of the H2Nx, H5Nx, and H7Nx influenza strains. Mice vaccinated with the pentavalent COBRA HA/NA vaccine showed little to no weight loss, no clinical signs of diseases, and were protected from mortality when challenged with the lethal H7N9 virus. Virus titers in the lungs of vaccinated mice were lower and cleared more rapidly than in mock-vaccinated mice. Some vaccinated mice showed no detectable lung injury or inflammation. Antibody-secreting cells were significantly increased in COBRA-vaccinated mice, with higher total Ig and H7-specific ASC. Thus, the combination of H2, H5, H7, N1, and N2 COBRA antigens presents a potential for the formulation of a universal influenza virus vaccine.

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