A Systematic Review of Impulse Control Disorders in Parkinson's Disease

Callesen, Mette Buhl; Scheel-Krüger, Jørgen; Kringelbach, Morten L.; Møller, Arne

doi:10.3233/jpd-120165

Cited by 116 publications

(70 citation statements)

References 223 publications

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“…For PD patients, initial cross-sectional studies that used formal assessments of ICDs reported an estimated prevalence of 1.7% to 7.0% for compulsive gambling, 3.5% for CSB, 27 and 0.4% to 3.0% for compulsive buying. [28][29][30][31] Compulsive or binge eating was also reported in PD, but its prevalence was not initially reported.…”

Section: Frequencymentioning

confidence: 99%

Clinical spectrum of impulse control disorders in Parkinson's disease

et al. 2014

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Impulse control disorders (ICDs), including compulsive gambling, buying, sexual behavior, and eating, are a serious and increasingly recognized psychiatric complication in Parkinson's disease (PD). Other impulsive-compulsive behaviors (ICBs) have been described in PD, including punding (stereotyped, repetitive, purposeless behaviors) and dopamine dysregulation syndrome (DDS; compulsive PD medication overuse). ICDs have been most closely related to the use of dopamine agonists (DAs), perhaps more so at higher doses; in contrast, DDS is primarily associated with shorter-acting, higher-potency dopaminergic medications, such as apomorphine and levodopa. Possible risk factors for ICDs include male sex, younger age and younger age at PD onset, a pre-PD history of ICDs, and a personal or family history of substance abuse, bipolar disorder, or gambling problems. Given the paucity of treatment options and potentially serious consequences, it is critical for PD patients to be monitored closely for development of ICDs as part of routine clinical care.

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Section: Frequencymentioning

confidence: 99%

Clinical spectrum of impulse control disorders in Parkinson's disease

et al. 2014

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“…Deep brain stimulation is an effective treatment for several neurological diseases and conditions, including Parkinson’s disease and depression (Mayberg, 2009; Callesen et al, 2013). In rodent studies, electrical stimulation of the LHb reduced cocaine cravings, self-administration, and reinstatement while improving extinction.…”

Section: Electrical Stimulation In the Lateral Habenula Reduces Cocaimentioning

confidence: 99%

The role of the habenula in drug addiction

Velasquez¹,

Molfese²,

Salas³

2014

Front. Hum. Neurosci.

131

108

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Interest in the habenula has greatly increased in recent years. The habenula is a small brain structure located posterior to the thalamus and adjacent to the third ventricle. Despite its small size, the habenula can be divided into medial habenula (MHb) and lateral habenula (LHb) nuclei that are anatomically and transcriptionally distinct. The habenula receives inputs from the limbic system and basal ganglia primarily via the stria medullaris. The fasciculus retroflexus is the primary habenular output from the habenula to the midbrain and governs release of glutamate onto gabaergic cells in the rostromedial tegmental nucleus (RMTg) and onto the interpeduncular nucleus. The resulting GABA released from RMTg neurons inactivates dopaminergic cells in the ventral tegmental area/substantia nigra compacta. Through this process, the habenula controls dopamine levels in the striatum. Thus, the habenula plays a critical role in reward and reward-associated learning. The LHb also modulates serotonin levels and norepinephrine release, while the MHb modulates acetylcholine. The habenula is a critical crossroad that influences the brain’s response to pain, stress, anxiety, sleep, and reward. Dysfunction of the habenula has been linked to depression, schizophrenia, and the effects of drugs of abuse. This review focuses on the possible relationships between the habenula and drug abuse.

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“…A recent study found that patients with ICDs were more likely to be on antidepressant medications and had more motor complications than those without ICDs (Mack et al, 2013). In addition to dopaminergic medications, studies also show that ICDs can be caused by deep brain stimulation of the subthalamic nucleus (Frank et al, 2007; Callesen et al, 2013a; but also see Santangelo et al, 2013). Studies also show that cognitive behavioral therapy can ameliorate ICDs in PD patients (Okai et al, 2013).…”

Section: Impulse Control Disorders In Pdmentioning

confidence: 99%

Neural and behavioral substrates of subtypes of Parkinson’s disease

Moustafa

Poletti

2013

Front. Syst. Neurosci.

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Parkinson’s disease (PD) is a neurological disorder, associated with rigidity, bradykinesia, and resting tremor, among other motor symptoms. In addition, patients with PD also show cognitive and psychiatric dysfunction, including dementia, mild cognitive impairment (MCI), depression, hallucinations, among others. Interestingly, the occurrence of these symptoms—motor, cognitive, and psychiatric—vary among individuals, such that a subgroup of PD patients might show some of the symptoms, but another subgroup does not. This has prompted neurologists and scientists to subtype PD patients depending on the severity of symptoms they show. Neural studies have also mapped different motor, cognitive, and psychiatric symptoms in PD to different brain networks. In this review, we discuss the neural and behavioral substrates of most common subtypes of PD patients, that are related to the occurrence of: (a) resting tremor (vs. nontremor-dominant); (b) MCI; (c) dementia; (d) impulse control disorders (ICD); (e) depression; and/or (f) hallucinations. We end by discussing the relationship among subtypes of PD subgroups, and the relationship among motor, cognitive, psychiatric factors in PD.

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A Systematic Review of Impulse Control Disorders in Parkinson's Disease

Cited by 116 publications

References 223 publications

Clinical spectrum of impulse control disorders in Parkinson's disease

Clinical spectrum of impulse control disorders in Parkinson's disease

The role of the habenula in drug addiction

Neural and behavioral substrates of subtypes of Parkinson’s disease

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