A systematic review of evidence for silver nanoparticle-induced mitochondrial toxicity

Maurer, Laura L.; Meyer, Joel N.

doi:10.1039/c5en00187k

Cited by 102 publications

(80 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Ag-NPs cause significant genotoxicity and cytotoxicity due to oxidative stress and inflammation (Asharani et al 2009;Ivask et al 2015;Maurer and Meyer 2016). Evidence of published literature suggested that Ag-NPs induce damage to DNA due to double strands breaks, fragmentation and fusions (AshaRani et al 2008;Kovvuru et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Assessment of toxicity in fresh water fish Labeo rohita treated with silver nanoparticles

2017

View full text Add to dashboard Cite

Silver nanoparticles (17.78 ± 12.12 nm) were synthesized by the reduction of 0.5 M silver nitrate using formaldehyde as reducing and triethylamine as promoting and stabilizing agent. The particles were grain like agglomerates with spherical, centered-face cubic and crystalline in nature. The sample was highly pure with amine (NH) as associated and capping molecules. Further, the genotoxicity and oxidative stress of these particles were evaluated using Labeo rohita (L. rohita) as genetic model exposed (10-55 mg L -1 dose) through aquatic medium for 28 days. The cells were produced with micronuclei, fragmented, lobed and buds nuclei in dose dependent manner. The highest incidence of comet was recoded (27.34 ± 5.68) at 55 mg L -1 Ag-NPs and 14 days treatment. Then frequency was decreased to 22.65 ± 6.66% after 28 days due to complex repair mechanism. Moreover, the treatment also produces the oxidative stress and disturbs the level of GST in gill and liver tissue. There was a sharp decline in the activities of GST and this decrease of activity increase the MDA content. Further, the elevated level of GSH represents that the liver has started defensive mechanism against oxyraidcals. This study concluded, Ag-NPs are genotoxic in nature and produce micronuclei, comet cells and also induces oxidative stress in aquatic organisms.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of toxicity in fresh water fish Labeo rohita treated with silver nanoparticles

2017

View full text Add to dashboard Cite

show abstract

“…There are several review papers published to address the issues associated with AgNPs in terms of their toxicology properties during their use as antimicrobial agents for textiles, dental biomaterials, and bio‐detectors, as well as during their syntheses . For instance, toxicity properties including cytotoxicity and genotoxicity of capped or uncapped AgNPs have been reviewed in detail .…”

Section: Introductionmentioning

confidence: 99%

A Review of Silver Nanoparticles: Research Trends, Global Consumption, Synthesis, Properties, and Future Challenges

Syafiuddin

Salmiati

Salim

et al. 2017

J Chinese Chemical Soc

331

176

View full text Add to dashboard Cite

Silver nanoparticles (AgNPs) are intensively investigated for their superior physical, chemical, and biological properties. A proper knowledge of these properties is essential to maximizing the potential applications of AgNPs in several areas while minimizing their risks to humans and the environment. This paper aims to critically review AgNPs from the perspectives of research trends, global consumption, synthesis, properties, and future challenges. Generally, AgNPs can be synthesized using three methods, namely physical, chemical, and biological, and the related works as well as their numerous advantages and disadvantages are presented in this review. In addition, AgNPs can be potentially explored for various applications. Future challenges on (AgNP) synthesis, their release into the environment, and scaling up production, as presented in the review, suggest that several potential topics for future works are available to promote a safer and more efficient use of these nanoparticles. Studies on AgNPs in Malaysia have increased since the Malaysian government officially established a directorate for nanotechnology development. This calls for a proper set of policies on AgNPs starting from their production to utilization as well as their effects on various related industries and the environment.

show abstract

“…The reviews published so far on nanoparticle toxicology provide information about toxicity of engineered nanoparticles to environmental microorganisms [20], titanium oxide nanoparticle toxicity [21], gold nanoparticle toxicity [21], risk management of inhaled nanoparticles [22], induced mitochondrial toxicity of silver nanoparticles [23] and single-wall carbon nanotube toxicity [24] and multi-wall carbon nanotube toxicity [25]. The published reviews are either too general or very specific (focusing on a single nanoparticle or toxicological effects on a particular organ) to explain the toxicity.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

View full text Add to dashboard Cite

Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

show abstract

A systematic review of evidence for silver nanoparticle-induced mitochondrial toxicity

Abstract: Here we review mitochondrial effects of silver nanoparticle (AgNP) exposure, which may mediate overall cytotoxicity observed following AgNP exposure.

Cited by 102 publications

References 110 publications

Assessment of toxicity in fresh water fish Labeo rohita treated with silver nanoparticles

Assessment of toxicity in fresh water fish Labeo rohita treated with silver nanoparticles

A Review of Silver Nanoparticles: Research Trends, Global Consumption, Synthesis, Properties, and Future Challenges

In vitro and in vivo toxicity assessment of nanoparticles

Contact Info

Product

Resources

About