A systematic review of epidemiology, risk factors, diagnosis, antifungal resistance, and management of invasive aspergillosis in Africa

Yerbanga, Isidore W.; Diallo, Seydou; Rouamba, Toussaint; Denis, Olivier; Rodriguez-Villalobos, Hector; Montesinos, Isabel; Bamba, Sanata

doi:10.1016/j.mycmed.2022.101328

Cited by 12 publications

(10 citation statements)

References 35 publications

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“…However, most of these estimates do not take into consideration the "at-risk population" and the clinical spectrum of invasive aspergillosis. The estimates per 100,000 population were 4.8 to 16 in Southern Africa, 0.05 to 10.9 in Northern Africa, and 0.3 to 6.25 in Western Africa while it ranges from 7.1 to 10.7 and 3.2 to 6.9 in Northern Africa and Central Africa, respectively [106].…”

Section: Invasive Aspergillosismentioning

confidence: 93%

Invasive Fungal Diseases in Africa: A Critical Literature Review

Bongomin

Ekeng

Kibone

et al. 2022

JoF

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Invasive fungal diseases (IFDs) are of huge concern in resource-limited settings, particularly in Africa, due to the unavailability of diagnostic armamentarium for IFDs, thus making definitive diagnosis challenging. IFDs have non-specific systemic manifestations overlapping with more frequent illnesses, such as tuberculosis, HIV, and HIV-related opportunistic infections and malignancies. Consequently, IFDs are often undiagnosed or misdiagnosed. We critically reviewed the available literature on IFDs in Africa to provide a better understanding of their epidemiology, disease burden to guide future research and interventions. Cryptococcosis is the most encountered IFD in Africa, accounting for most of the HIV-related deaths in sub-Saharan Africa. Invasive aspergillosis, though somewhat underdiagnosed and/or misdiagnosed as tuberculosis, is increasingly being reported with a similar predilection towards people living with HIV. More cases of histoplasmosis are also being reported with recent epidemiological studies, particularly from Western Africa, showing high prevalence rates amongst presumptive tuberculosis patients and patients living with HIV. The burden of pneumocystis pneumonia has reduced significantly probably due to increased uptake of anti-retroviral therapy among people living with HIV both in Africa, and globally. Mucormycosis, talaromycosis, emergomycosis, blastomycosis, and coccidiomycosis have also been reported but with very few studies from the literature. The emergence of resistance to most of the available antifungal drugs in Africa is yet of huge concern as reported in other regions. IFDs in Africa is much more common than it appears and contributes significantly to morbidity and mortality. Huge investment is needed to drive awareness and fungi related research especially in diagnostics and antifungal therapy.

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Section: Invasive Aspergillosismentioning

confidence: 93%

Invasive Fungal Diseases in Africa: A Critical Literature Review

Bongomin

Ekeng

Kibone

et al. 2022

JoF

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“…However, this finding was different from reports in African nations, where A. flavus and A. niger are the most prevalent aspergillus species. 3 Further research should focus on prospective studies to validate the predictive value of BALF galactomannan levels and other identified risk factors. Additionally, exploring the role of immunomodulatory treatments and their impact on the incidence and progression of IPA in these patients could provide new therapeutic avenues.…”

Section: Dear Editormentioning

confidence: 99%

Response to “Prevalence, Risk Factors, and Mortality of Invasive Pulmonary Aspergillosis in Patients with Anti-MDA5 + Dermatomyositis: A Retrospective Study in China” [Letter]

Prisusanti,

Suhariyono,

Mahdi

2024

JIR

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“…Newly synthesized pyrazoles were evaluated for their antifungal effectiveness against two fungal strains, A. niger and C. albicans, using the serial plate dilution method in a DMSO solution [11,12]. A Sabouraud agar medium was prepared by dissolving 1g of peptone, 4 g of D-glucose, and 2 grams of agar in 100 ml of distilled water, adjusting the pH to 5.7.…”

Section: In Vitro Antifungal Studiesmentioning

confidence: 99%

Studies on Photophysical and Biological Activity of Newly Synthesized of 4-Methylpiperidin-4-ol Substituted Pyrazole Derivatives

Al-Hazmi,

Marrakkur,

Naik

et al. 2024

Pol. J. Environ. Stud.

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A systematic review of epidemiology, risk factors, diagnosis, antifungal resistance, and management of invasive aspergillosis in Africa

Cited by 12 publications

References 35 publications

Invasive Fungal Diseases in Africa: A Critical Literature Review

Invasive Fungal Diseases in Africa: A Critical Literature Review

Response to “Prevalence, Risk Factors, and Mortality of Invasive Pulmonary Aspergillosis in Patients with Anti-MDA5 + Dermatomyositis: A Retrospective Study in China” [Letter]

Studies on Photophysical and Biological Activity of Newly Synthesized of 4-Methylpiperidin-4-ol Substituted Pyrazole Derivatives

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