A Systematic Review of Effects of Vitamin E on the Cardiovascular System

Shah, Sunil; Shiekh, Yasir; Lawrence, Jannel A; Ezekwueme, Francis; Alam, Mohammad Zahangir; Kunwar, Saru; Gordon, Domonick K

doi:10.7759/cureus.15616

Cited by 10 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is a fatsoluble antioxidant that works exclusively by quenching peroxyl radicals to disrupt the chain reaction of LPO [3]. α-Tocopherol donates a proton to peroxyl radicals, forming a tocopherol radical that reacts with another peroxyl radical to give non-reactive products [48].…”

Section: Defensive Mechanisms To Minimise Ocular Oxidative Stressmentioning

confidence: 99%

The Potential of Selenium-Based Therapies for Ocular Oxidative Stress

Al-Bassam,

Shearman,

Brocchini

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Oxidative stress plays a critical role in the development of chronic ocular conditions including cataracts, age-related macular degeneration, and diabetic retinopathy. There is a need to explore the potential of topical antioxidants to slow the progression of those conditions by mediating oxidative stress and maintaining ocular health. Selenium has attracted considerable attention because it is a component of selenoproteins and antioxidant enzymes. The application of selenium to a patient can increase selenoprotein expression, counteracting the effect of reactive oxygen species by increasing the presence of antioxidant enzymes, and thus slowing the progression of chronic ocular disorders. Oxidative stress effects at the biomolecular level for prevalent ocular conditions are described in this review along with some of the known defensive mechanisms, with a focus on selenoproteins. The importance of selenium in the eye is described, along with a discussion of selenium studies and uses. Selenium’s antioxidant and anti-inflammatory qualities may prevent or delay eye diseases. Recent breakthroughs in drug delivery methods and nanotechnology for selenium-based ocular medication delivery are enumerated. Different types of selenium may be employed in formulations aimed at managing ocular oxidative stress conditions.

show abstract

Section: Defensive Mechanisms To Minimise Ocular Oxidative Stressmentioning

confidence: 99%

The Potential of Selenium-Based Therapies for Ocular Oxidative Stress

Al-Bassam,

Shearman,

Brocchini

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…The first step in the formation of atherosclerotic plaques involves the recruitment of inflammatory cells, such as blood monocytes, which differentiate into resident macrophages in the vascular intima, allowing interaction with lipoproteins and formation of the fatty streaks, considered the initial lesions of atherosclerosis ( Libby, 2021a ). Interestingly, despite the contribution of oxidized low-density lipoprotein (LDL) to the formation of foam cells, antioxidant therapies have failed to prevent the complications of atherosclerosis ( Witztum & Steinberg 1991 ; Shah et al, 2021 ). However, oxidized LDL also triggers proinflammatory stimuli and it is possible that antioxidant therapy is ineffective in the most advanced phases of the disease, where inflammatory stimuli predominate.…”

Section: Inflammation and Atherosclerosismentioning

confidence: 99%

Role of Inflammation in Cardiac Remodeling After Acute Myocardial Infarction

Fonseca

Izar

2022

Front. Physiol.

View full text Add to dashboard Cite

Atherosclerosis is defined as an inflammatory disease. Low-grade inflammation is present in all phases of the cardiovascular continuum, since the establishment of cardiovascular risk factors and ischemic heart disease until cardiovascular events, such as myocardial infarction, heart failure and death. Not all inflammatory pathways are linked to cardiovascular outcomes, and thus, not all anti-inflammatory approaches decrease cardiovascular events. The most common cause of ventricular remodeling and heart failure is ischemic heart disease. Biomarkers such as high-sensitivity C-reactive protein can identify individuals at risk of major cardiovascular complications, but this biomarker has no causal effect on cardiovascular disease. On the other hand, interleukin 6 appears to be causally associated with cardiovascular disease. CANTOS was the first proof of concept study showing that anti-inflammatory therapy reduces major cardiovascular outcomes. Based on many anti-inflammatory trials, only therapies acting on the NLRP3 inflammasome, or interleukin 1beta, showed benefits on cardiovascular disease. Ventricular remodeling, particularly after myocardial infarction seems also influenced by the intensity of inflammatory responses, suggesting that anti-inflammatory therapies may reduce the residual cardiovascular risk. Inflammasome (NLRP3) activation, subtypes of lymphocytes, interleukin 6, and some inflammatory biomarkers, are associated with larger infarct size and impaired ventricular function after myocardial infarction. Cardiovascular risk factors commonly present in patients with myocardial infarction, and advanced age are associated with higher inflammatory activity.

show abstract

“…Vitamin E, also known as a menopausal vitamin, is recently considered an estrogen alternative [ 9 ]. The vitamin E family is comprised of eight fat-soluble compounds including four tocopherols and four tocotrienols that exert antioxidant activities [ 17 ]. Few studies have evaluated the efficacy of vitamin E in terms of alleviating menopausal symptoms, the results of which are contradictory [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized Controlled Trial

Farshbaf‐Khalili

Ostadrahimi

Mirghafourvand

et al. 2022

Journal of Nutrition and Metabolism

View full text Add to dashboard Cite

Aims of the Study. Reducing estrogen levels due to menopause activates oxidative and inflammatory processes, which causes symptoms of menopause, anxiety, and sexual dysfunction. As a suggestion, potential anti-inflammatory and antioxidant agents such as curcumin and vitamin E could be used as an effective alternative treatment due to parsimony, suitable access, and fewer side effects. Therefore, the present study was conducted to find out whether supplementation with curcumin and vitamin E affects inflammatory-oxidative stress biomarkers and primary symptoms of menopause in healthy postmenopausal women. Methods Used to Conduct the Study. The present study is a triple-blind parallel randomized controlled trial. Eighty-four eligible postmenopausal women aged 40 to 60 years old were randomly assigned into three groups using block randomization with an allocation ratio of 1 : 1 : 1. The curcumin group received one capsule containing 500 mg curcumin twice a day, the vitamin E group received one 500 mg capsule of vitamin E twice a day, and the placebo group took two placebo capsules containing 500 mg of microcrystalline cellulose (MCC) daily for eight weeks. Demographic and anthropometric characteristics, dietary intake, and early symptoms of menopause were collected at baseline. Serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), and high sensitivity C-reactive protein (hs-CRP) were measured at baseline and after the intervention. Intervention safety and satisfaction with the intervention were also evaluated. Results of the Study. Eighty-one participants completed the trial and were finally analyzed. There were no statistically significant differences in demographic characteristics and dietary intake of participants (except for vitamin C intake, P = 0.023 ) between the groups at baseline. The mean ± standard deviation (SD) score of total menopause symptoms, depression, anxiety, psychological, vasomotor, and physical domains significantly decreased within all groups ( P < 0.05 ). Between-group analyses indicated that decreasing the mean score of anxiety in the vitamin E group was significantly more than in the placebo group ( P = 0.026 ). The mean (SD) serum levels of MDA and hs-CRP significantly decreased only in the curcumin group ( P = 0.009 and P = 0.025 , respectively). Serum levels of TAC significantly increased in curcumin and vitamin E groups ( P < 0.001 and P = 0.006 , respectively). Conclusions Drawn from the Study and Clinical Implications. Curcumin could improve the oxidative stress (MDA and TAC) and inflammatory (hs-CRP) biomarkers. Vitamin E may also improve the antioxidant status by increasing the TAC levels. The alleviation of anxiety in the vitamin E group was more than in the placebo group. Clinical Trial Registration. The trial was registered at the Iranian Registry of Clinical Trials (https://irct.ir/IRCT20131009014957N6).

show abstract

A Systematic Review of Effects of Vitamin E on the Cardiovascular System

Cited by 10 publications

References 36 publications

The Potential of Selenium-Based Therapies for Ocular Oxidative Stress

The Potential of Selenium-Based Therapies for Ocular Oxidative Stress

Role of Inflammation in Cardiac Remodeling After Acute Myocardial Infarction

Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized Controlled Trial

Contact Info

Product

Resources

About