A systematic review of decellularized allograft and xenograft–derived scaffolds in bone tissue regeneration

Amini, Zahra; Lari, Roya

doi:10.1016/j.tice.2021.101494

Cited by 58 publications

(42 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Up until this stage, there is no definite choice of materials in terms of orbital wall reconstruction. Thus, exploration of novel alternatives such as the xenograft framework can be a solution to this issue 27 . Xenograft decellular framework such as ABCcolla ® Collagen Bone Graft has been gaining popularity in orthopedic and dental applications, but its application in orbital wall reconstruction was not yet explored 4 .…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of the orbital floor using supercritical CO₂ decellularized porcine bone graft

Huang

Hsieh²,

et al. 2021

Int. J. Med. Sci.

View full text Add to dashboard Cite

Orbital floor fractures subsequently lead to consequences such as diplopia and enophthalmos. The graft materials used in orbital floor fractures varied from autografts to alloplastic grafts, which possess certain limitations. In the present study, a novel porcine bone matrix decellularized by supercritical CO2 (scCO2), ABCcolla® Collagen Bone Graft, was used for the reconstruction of the orbital framework. The study was approved by the institutional review board (IRB) of Kaohsiung Medical University Chung-Ho Memorial Hospital (KMUH). Ten cases underwent orbital floor reconstruction in KMUH in 2019. The orbital defects were fixed by the implantation of the ABCcolla® Collagen Bone Graft. Nine out of ten cases used 1 piece of customized ABCcolla® Collagen Bone Graft in each defect. The other case used 2 pieces of customized ABCcolla® Collagen Bone Graft in one defect area due to the curved outline of the defect. In the outpatient clinic, all 10 cases showed improvement of enophthalmos on CT (computerized tomography) at week 8 follow-up. No replacement of implants was needed during follow-ups. To conclude, ABCcolla® Collagen Bone Graft proved to be safe and effective in the reconstruction of the orbital floor with high accessibility, high stability, good biocompatibility, low infection rate and low complication rate.

show abstract

Section: Discussionmentioning

confidence: 99%

Reconstruction of the orbital floor using supercritical CO₂ decellularized porcine bone graft

Huang

Hsieh²,

et al. 2021

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Cell-based biomaterials are considered to have problems in tumorigenicity, preservability, and susceptibility to infection [68][69][70]. To resolve these issues, decellularization treatment is often conducted by detergent, high-pressure, or freeze-drying of the biomaterials [71][72][73]. We focused on the freeze-dry processing that has been applied to medical products and food industry because this technology also improves the operability and stability of cell-based biomaterials [74].…”

Section: Freeze-dry Processing Of 3d Cell Constructsmentioning

confidence: 99%

Large three-dimensional cell constructs for tissue engineering

Sasaki

Abe

et al. 2021

Science and Technology of Advanced Materials

View full text Add to dashboard Cite

Much research has been conducted on fabricating biomimetic biomaterials in vitro. Tissue engineering approaches are often conducted by combining cells, scaffolds, and growth factors. However, the degradation rate of scaffolds is difficult to control and the degradation byproducts occasionally limit tissue regeneration. To overcome these issues, we have developed a novel system using a thermo-responsive hydrogel that forms scaffold-free, three-dimensional (3D) cell constructs with arbitrary size and morphology. 3D cell constructs prepared using bone marrow-derived stromal stem cells (BMSCs) exhibited self-organizing ability and formed bone-like tissue with endochondral ossification. Endothelial cells were then introduced into the BMSC construct and a vessel-like structure was formed within the constructs. Additionally, the bone formation ability was promoted by endothelial cells and cell constructs could be freeze-dried to improve their clinical application. A pre-treatment with specific protein protectant allowed for the fabrication of novel bone substitutes composed only of cells. This 3D cell construct technology using thermo-responsive hydrogels was then applied to other cell species. Cell constructs composed of dental pulp stem cells were fabricated, and the resulting construct regenerated pulp-like tissue within a human pulpless tooth. In this review, we demonstrate the approaches for the in vitro fabrication of bone and dental pulp-like tissue using thermo-responsive hydrogels and their potential applications.

show abstract

“…Therefore, either damage or loss of bone tissue can cause great inconvenience to patients, and the treatment of large-area bone defects still faces great challenges. Autologous bone transplantation is the "gold standard" in the field of bone repair, but it is difficult to achieve because of secondary injury to patients [1,2]. Allogeneic bone transplantation also has many deficiencies, such as immune rejection and infectious diseases [3].…”

Section: Introductionmentioning

confidence: 99%

3D Printing of PLLA/Biomineral Composite Bone Tissue Engineering Scaffolds

Gang

et al. 2022

Materials

View full text Add to dashboard Cite

Tissue engineering is one of the most effective ways to treat bone defects in recent years. However, current highly active bone tissue engineering (BTE) scaffolds are mainly based on the addition of active biological components (such as growth factors) to promote bone repair. High cost, easy inactivation and complex regulatory requirements greatly limit their practical applications. In addition, conventional fabrication methods make it difficult to meet the needs of personalized customization for the macroscopic and internal structure of tissue engineering scaffolds. Herein, this paper proposes to select five natural biominerals (eggshell, pearl, turtle shell, degelatinated deer antler and cuttlebone) with widely available sources, low price and potential osteo-inductive activity as functional particles. Subsequently compounding them into L-polylactic acid (PLLA) biomaterial ink to further explore 3D printing processes of the composite scaffold, and reveal their potential as biomimetic 3D scaffolds for bone tissue repair. The research results of this project provide a new idea for the construction of a 3D scaffold with growth-factor-free biomimetic structure, personalized customization ability and osteo-inductive activity.

show abstract

A systematic review of decellularized allograft and xenograft–derived scaffolds in bone tissue regeneration

Cited by 58 publications

References 111 publications

Reconstruction of the orbital floor using supercritical CO₂ decellularized porcine bone graft

Reconstruction of the orbital floor using supercritical CO₂ decellularized porcine bone graft

Large three-dimensional cell constructs for tissue engineering

3D Printing of PLLA/Biomineral Composite Bone Tissue Engineering Scaffolds

Contact Info

Product

Resources

About

A systematic review of decellularized allograft and xenograft–derived scaffolds in bone tissue regeneration

Cited by 58 publications

References 111 publications

Reconstruction of the orbital floor using supercritical CO2 decellularized porcine bone graft

Reconstruction of the orbital floor using supercritical CO2 decellularized porcine bone graft

Large three-dimensional cell constructs for tissue engineering

3D Printing of PLLA/Biomineral Composite Bone Tissue Engineering Scaffolds

Contact Info

Product

Resources

About

Reconstruction of the orbital floor using supercritical CO₂ decellularized porcine bone graft

Reconstruction of the orbital floor using supercritical CO₂ decellularized porcine bone graft