Abstract:Effective diagnosis, prognostication and management of central nervous system (CNS) malignancies traditionally involves invasive brain biopsy but sampling and molecular profiling of cerebrospinal fluid (CSF) is a safer, rapid and non-invasive alternative that can offer a snapshot of the intracranial milieu. While numerous assays and biomarkers have been analyzed, translational challenges remain, and standardization of protocols is necessary. Here we systematically reviewed 141 studies (Medline, SCOPUS, and Bio… Show more
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