A Systematic Review of Clinical Efficacy of Adjunctive Antibiotics in the Treatment of Smokers With Periodontitis

Angaji, Mahdi; Gelskey, Shirley C.; Nogueira-Filho, Getulio; Brothwell, Doug

doi:10.1902/jop.2010.100192

Cited by 37 publications

(35 citation statements)

References 49 publications

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Section: Discussionmentioning

confidence: 99%

“…[1819] The results of various studies have shown Azi as an effective drug in controlling periodontitis as an adjuvant to the periodontal therapy. [1316171819] Although Azi has also been observed to be effective in improving DIGO but this conclusion still needs to be explored. [9101120] and therefore, the present study was undertaken to evaluate the efficacy of Azi in inhibiting the GO caused by CsA + Nf combination therapy in SD rat model.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats

Ratre¹,

Mehta

2016

J Indian Soc Periodontol

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Background:Drug-induced gingival overgrowth (DIGO) is a well-known adverse effect of cyclosporine A (CsA) and nifedipine (Nf) therapy. The aim of the present morphometric study was to evaluate the effect of azithromycin (Azi) on the combined GO in rats induced by CsA + Nf combination.Materials and Methods:Thirty Sprague-Dawley male rats were randomly divided equally into three groups. Group 1 (control) received olive oil only; Group 2 received a combination of CsA and Nf in olive oil throughout the study period; Group 3 received CsA + Nf combination therapy, and Azi was added for 1 week in the 5th week. All the drugs were delivered by oral route. Impressions of the mandibular central incisal regions were taken, and study models were prepared at baseline and biweekly up to the 8 weeks. Statistical analysis was done by one-way analysis of variance and intergroup comparisons were made using Tukey's post hoc analysis.Results:Significant GO was evident in Group 2 and Group 3 rats when compared to Group 1. However, in Group 3 (Azi), GO was observed up to the 4th week, but a significant decrease in GO was noticed during 6–8th week after the administration of Azi in 5th week.Conclusion:Azi is an effective drug in the remission of DIGO induced by combined therapy of CsA + Nf and thereby can be considered as a useful therapeutic regimen in minimizing the DIGO in transplant patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats

Ratre¹,

Mehta

2016

J Indian Soc Periodontol

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“…In the present study, 20% of the professionals reported indicating the use of antibiotics in the treatment of chronic periodontitis, irrespective of the severity of the disease or the patient's smoking habit, aspects considered relevant when the use of antibiotic therapy is referred to in chronic periodontal disease therapy. In spite of these studies demonstrating positive results with the use of antibiotics as adjunct to the treatment of chronic periodontitis 2,3,8,18,28,30 , a recent systematic review showed that there is still insufficient and inconclusive evidence to support the use of systemic antibiotics 31 . Although most of the mentioned professionals concern about associating antibiotic with mechanical therapy, 33% of the professionals used antibiotic therapy alone.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the use of systemic antimicrobial agents by professionals for the treatment of periodontal diseases

Monteiro¹,

Ribeiro²,

Casarin³

et al. 2013

Braz. J. Oral Sci.

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Aim: To investigate the indication of systemic antimicrobial agents used by dental professionals for treatment of patients affected by periodontal diseases. Methods: Interviews by a questionnaire were held with 225 professionals of different dental specialties and who performed periodontal treatment. Results: Among interviewees, 94% indicated systemic antibiotics as a form of periodontal disease treatment. Their main indication was for periodontal abscesses (80%) followed by aggressive periodontitis (62%) and necrotizing diseases (45%). The most frequently used antibiotics were amoxicillin (81%) and metronidazole (57%). The medications were indicated in association with mechanical therapy by 67% of the professionals. As regards the occasion of indication, 60% indicated systemic antibiotic therapy before and after mechanical periodontal scaling and root planing. Seventy-eight percent of the professionals indicated antibiotics associated with periodontal surgery for access to scaling, and 76% indicated it before and after the surgical procedure. Among the interviewees, 99% took into account systemic involvement for drug administration. Conclusions: It was concluded that a considerable portion of professionals indicate systemic antibiotic-therapy in an incoherent manner and in situations in which there is no indication for antibiotic use, or with ineffective protocols.

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“…Moreover, patients in the test group, who received an intramucosal injection of thermosetting gel containing 3% doxycycline hyclate had lower values of all parameters studied than the control group. Doxycycline, a broad-spectrum semisynthetic tetracycline, is one of the antibiotics most widely used in many fields of medicine; it is unanimously reported to be of great importance in the treatment of various diseases, especially periodontitis (16,17).…”

Section: Discussionmentioning

confidence: 99%

Effect of Thermosetting Gel with Doxycycline Hyclate 3% on Postoperative Discomfort after Third Molar Surgery: A Prospective Study

et al. 2013

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The study evaluated the effect of intra-alveolar administration of a thermosetting gel containing doxycyclyne hylcate 3% on patient discomfort after third molar surgery. Eighty-five consecutive patients requiring surgical removal of a single maxillary or mandibular impacted third molar were randomly selected and divided into 2 groups. After the onset of local anaesthesia, the experimental groups received 2 different antibiotic protocols: rifampicin for the first group and a thermosetting gel containing doxycyclyne hylcate 3% for the second group. Standardized surgical protocols were followed. The patients' perception of the severity of symptoms (pain, swelling, reddening, bleeding and body temperature) was assessed with a follow-up questionnaire (PoSSe scale). On the second postoperative day, pain, reddening and bleeding showed a statistically significant reduction in Group 2 compared with Group 1. There was no difference between the two groups when postoperative swelling was evaluated on the second day. From the third day, conversely, swelling decreased faster in Group 2 than in Group 1. Our data demonstrate that the use of the thermosetting gel containing doxycyclyne hylcate 3%, given as an intra-alveolar injection at the end of surgery, is effective in the prevention of postoperative symptoms after third molar extraction.The surgical removal of impacted third molars involves trauma to soft and bony tissue and can result in considerable pain, swelling, reddening and bleeding. These postoperative sequela can cause stress to the patient and affect the patient's quality of life after surgery. These sequelae can happen also after surgical-orthodontic treatments (1-3). Prediction of impaction of third molars in patients could be of great help in the planning of orthodontic treatment, surgery, or prostheses (4-8).The need for better discomfort control in patients who undergo third molar surgery is widely recognized, and several types of medications have been proposed (9). In order to improve the postoperative course, the surgical procedure must be appropriate and as far as possible non-traumatic; it is also useful to prescribe a suitable medication protocol.The aim ofthe antibiotic prophylaxis, is to protect the patient from the consequences of transient

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A Systematic Review of Clinical Efficacy of Adjunctive Antibiotics in the Treatment of Smokers With Periodontitis

Cited by 37 publications

References 49 publications

Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats

Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats

Evaluation of the use of systemic antimicrobial agents by professionals for the treatment of periodontal diseases

Effect of Thermosetting Gel with Doxycycline Hyclate 3% on Postoperative Discomfort after Third Molar Surgery: A Prospective Study

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