A systematic review of circulating-free MYCN amplification status as a noninvasive and prominent prognostic and recurrence monitoring indicator for neuroblastoma
Abstract:MYCN gene plays an important role in neuroblastoma cell growth,
apoptosis, differentiation, tumor infiltration, metastasis, and
angiogenesis. MYCN gene amplification status in tumor tissue is
one of the important clinical indicators of neuroblastoma risk. However,
there are several problems in detecting the MYCN gene in tumor
tissues, such as complex procedures in detection approaches, high
detection costs, and difficulty in obtaining tumor tissues. Studies have
shown that circulating-free MYCN gene amplificat… Show more
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