A Systematic Review of Associations of Physical Activity and Sedentary Time with Asthma Outcomes

Cordova-Rivera, Laura; Gibson, Peter G.; Gardiner, Paul A.; McDonald, Vanessa M.

doi:10.1016/j.jaip.2018.02.027

Cited by 97 publications

(120 citation statements)

References 80 publications

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“…There was an increased risk of current asthma in children who engaged in regular physical exercise (three or more times in a week), similar to that reported in some studies . Though the exact mechanism is unknown, two theories have been proposed: an airway humidity theory, which suggests that air movement through the airway results in relative drying of the airway that serves as a trigger to a cascade of events that then result in airway edema and bronchospasm in susceptible children.…”

Section: Discussionsupporting

confidence: 75%

“…[34][35][36] There was an increased risk of current asthma in children who engaged in regular physical exercise (three or more times in a week), similar to that reported in some studies. [37][38][39][40][41][42][43][44][45] Though the exact mechanism is unknown, two theories have been proposed: an airway humidity theory, which suggests that air movement through the airway results in relative drying of the airway that serves as a trigger to a cascade of events that then result in airway edema and bronchospasm in susceptible children. The other theory, based on airway cooling phenomenon, notes that the air moving in the bronchial tree results in a decreased temperature, which triggers a hyperemic response within the bronchi, in an effort to re-heat the airway.…”

Section: Many Households In Low and Middle-income Countries Burnmentioning

confidence: 99%

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Environmental risk factors for asthma in 13‐14 year old African children

Ayuk

Ramjith

Zar

2018

Pediatric Pulmonology

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Background Asthma prevalence in African children is high. Factors driving the prevalence or disease severity are poorly understood. This study aims to investigate environmental factors associated with asthma and severity in African children. Methods Population based cross‐sectional study of children aged 13–14 years from 10 African centers who participated in ISAAC III. Self‐reported environmental exposures included engaging in physical exercise, television watching, various biomass and ETS exposure, consumption of paracetamol, large family sizes and having pets in the home. Univariable and multivariable analyses were done adjusting for center variations. Prevalences, odds ratio and 95% confidence intervals (CI) were calculated. Results There were 258 267 children recruited among the 13‐14‐year‐old participants. Of these, 28,391 respondents from 232 schools completed both the written questionnaire (WQ) and environmental questionnaire (EQ). The prevalence of asthma and severe asthma were 12.8% (CI 12.4‐13.2), and 8.7% (CI 8.4‐8.0) respectively. Factors strongly associated with asthma were maternal smoking (OR = 1.41; 95%CI: 1.23‐1.64), open fire heating (OR = 1.28; 95%CI: 1.08‐1.51) electric heating (OR = 1.13; 95%CI: 1.01‐1.28), physical exercise (OR = 1.29; 95%CI: 1.11‐1.50), monthly paracetamol use (OR 1.23; 95%CI 1.13‐1.33), having an elder sibling (OR = 0.87; 95%CI 0.77‐0.98). Factors associated with severe asthma were maternal smoking (OR = 1.61; 95%CI: 1.38‐1.89), cat pet (OR = 1.14; 95%CI: 1.04‐1.25), frequent physical exercise (OR = 1.42; 95%CI: 1.23‐1.64) and monthly paracetamol use (OR = 1.20; 95%CI 1.07, 1.34). Conclusion Several environmental exposures were associated with asthma and severe disease.

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Section: Discussionsupporting

confidence: 75%

Section: Many Households In Low and Middle-income Countries Burnmentioning

confidence: 99%

Environmental risk factors for asthma in 13‐14 year old African children

Ayuk

Ramjith

Zar

2018

Pediatric Pulmonology

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“…illness perception (Canonica et al, 2018). PA levels are strictly related to QoL: PA levels are improved in populations with a high QoL (Mazzeo et al, 2016;Monda et al, 2017b;Wu et al, 2017;Cordova-Rivera et al, 2018a;Sessa et al, 2018a). In our preliminary real-life study, for the first time, we demonstrated the improvement of the QoL of SA patients treated with biologics in terms of PA levels and, indirectly, in terms of the AQLQ score.…”

Section: Discussionmentioning

confidence: 69%

Physical Activity as a New Tool to Evaluate the Response to Omalizumab and Mepolizumab in Severe Asthmatic Patients: A Pilot Study

et al. 2020

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Asthma is a chronic inflammatory airway disease, representing one of the most severe pathologies in developed countries. Based on a report of the World Health Organization (WHO), it affects about 300 million people worldwide. Few studies have analyzed the effects of daily life physical activity (PA) levels in patients with asthma: moreover, little research has been carried out on PA levels in patients suffering from severe asthma (SA). This study aimed to investigate the PA levels in two groups of patients suffering from SA; in particular, this study analyzed the changes that occur in patients treated with biologic therapy (BT group) and patients who underwent traditional treatment (TT group) over 6 months. Moreover, this study represents a pilot study because, to the best of our knowledge, it is the first investigation that analyzed if the kind of biologic drug (omalizumab or mepolizumab) can produce differences in the PA levels of SA patients. Fifty SA patients were enrolled and PA parameters were monitored for 6 months. Subjects were divided into two treatment groups: TT (20 patients) and BT (30 patients), the BT group was further subdivided according to the drugs used (15, omalizumab; 15, mepolizumab). During drug treatment, all subjects improved their PA levels: indeed, considering the intragroup variation, the PA levels were significantly higher comparing the T6 levels to baseline (T0, p < 0.01). Considering the intragroup variation, it is very interesting to note that biologic therapy improved PA levels compared to the effects of traditional therapy; while at T0 there were no significant differences in the steps per day (SPD) values between the two groups (T0, p = 0.85), the differences become statistically significant at T1, T3, and T6 (T1, p = 0.019; T3, p = 3.48x10 −6 ; T6, p = 4.78x10 −10). As expected, the same differences were reported analyzing the energy expenditure data. In

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“…Earlier population-based evidence collectively suggests that individuals with asthma are less likely to engage in physical activity and less likely to engage in more intense exercise than those without asthma as well as less likely to engage in physical activity at recommended levels [26][27][28][29]. A recent systematic review among all available studies using a control group, identified 11 studies (asthma sample = 32,606) reporting less physical activity in asthma, and 6 studies (asthma sample = 7824) reporting no difference thus leading to the conclusion that people with asthma engage in less activity compared to controls [30]. Data on sedentary time in asthma are still scarce [30].…”

Section: Physical Activity In Asthmamentioning

confidence: 99%

Physical Activity: A Missing Link in Asthma Care

Panagiotou

Koulouris

Rovina

2020

JCM

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Asthma is the commonest respiratory disease and one of unceasingly increasing prevalence and burden. As such, asthma has attracted a major share or scientific interest and clinical attention. With the various clinical and pathophysiological aspects of asthma having been extensively investigated, the important association between asthma and physical activity remains underappreciated and insufficiently explored. Asthma impacts adversely on physical activity. Likewise, poor physical activity may lead to worse asthma outcomes. This concise clinical review presents the current recommendations for physical activity, discusses the available evidence on physical activity in asthma, and examines the causes of low physical activity in adult asthmatic patients. It also reviews the effect of daily physical activity and exercise training on the pathology and clinical outcomes of asthma. Finally, it summarizes the evidence on interventions targeting physical activity in asthma.

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A Systematic Review of Associations of Physical Activity and Sedentary Time with Asthma Outcomes

Cited by 97 publications

References 80 publications

Environmental risk factors for asthma in 13‐14 year old African children

Environmental risk factors for asthma in 13‐14 year old African children

Physical Activity as a New Tool to Evaluate the Response to Omalizumab and Mepolizumab in Severe Asthmatic Patients: A Pilot Study

Physical Activity: A Missing Link in Asthma Care

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