A systematic review involving 11,187 participants evaluating the impact of COVID-19 on anxiety and depression in pregnant women

Abstract

Background: COVID-19 has started to spread within China since the end of December 2019. As a special population, the pregnant and delivery women maybe influenced both in physical and psychological aspects. The meta-analysis was conducted about mental health in pregnant and delivery women. Methods: We searched both MEDLINE, EMBASE, Cochrane Library in English and CBM, CNKI, WANFANG and CSSCI in Chinese to find literature from December 2019 to 31 July 2020 related to COVID-19 and mental health in patient with pregnancy and delivery, among which results such as comments, letters, reviews and case reports were excluded. The prevalence of anxiety and depression in the population was synthesized and discussed. Results: A total of 11,187 subjects were included in 15 studies. Random effect model is used to account for the data by Revman 5.2. The results showed that the prevalence of depression was 30% (95% CI: 0.23-0.37), the prevalence of anxiety was 34% (95% CI: 0.26-0.43) and prevalence of both anxiety and depression was 18% (95% CI: 0.09-0.29). The prevalence of anxiety (OR ¼ 2.15, 95% CI: 1.39-3.31, Z ¼ 3.47, p¼.0005), depression (OR ¼ 1.95, 95% CI: 1.07-3.56, Z ¼ 2.19, p¼.03) were higher than that of controls. Significant heterogeneity was detected across studies regarding these prevalence estimates. Subgroup analysis was taken according to assessment tools, and sensitivity analysis was done to explore the sources of heterogeneity. Conclusions: The higher prevalence of depression, anxiety, both depression and anxiety in women with pregnancy and delivery during COVID-19 pandemic although the significant heterogeneity detected in studies. We must interpret the results with caution and also put attention to this result. As the epidemic is ongoing, it is vital to set up a comprehensive crisis prevention system.

Perinatal Mental Health during COVID-19 Pandemic: An Integrative Review and Implications for Clinical Practice

“…The heterogeneity of study designs and inconsistent results clearly indicate the need for summative research-namely reviews, which contribute to delineate the impact of the pandemic on the mental state of pregnant women and new mothers. Previous systematic reviews [16,17,19,20] and a recent rapid review [18] have focused on the prevalence of anxiety and depression among pregnant women and new mothers.…”

“…A few systematic reviews with meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [15] have been carried out. The results of the reviews concerning antenatal psychological symptoms indicate increased severity of anxiety [16] and increased prevalence of anxiety and depression [17][18][19] in pregnant women during the COVID-19 pandemic. Based on a systematic review with meta-analysis, Yan et al [20] found high rates of anxiety, depression and insomnia in pregnant women and new mothers.…”

Stress, anxiety and depression in 1466 pregnant women during and before the COVID-19 pandemic: a Dutch cohort study

“…The systematic review by Sun et al [10] showed an overall prevalence of 30% for depression and 34% for anxiety. When specifically looking at depression rates, it ranges from 11-65% between studies and subgroup analyses showed a large difference in relation to different assessment tools.…”

“…Several studies have been conducted regarding the mental health of pregnant women during COVID-19. Sun et al [10] conducted a systematic review including 15 studies about pregnant women that were performed during the first wave of the pandemic. The results showed an overall prevalence of 30% (range 11-65%) for depression and 34% (range 18-56%) for anxiety, although significant heterogeneity was seen.…”

Screening out anti-inflammatory or anti-viral targets in Xuanfei Baidu Tang through a new technique of reverse finding target

“…At the end of 2019, the novel coronavirus disease (COVID-19) appeared and caused global concern. It is a highly infectious disease characterized by respiratory symptoms [1] . COVID-19 pandemic has caused an unprecedented and uncontrollable health crisis.…”