Indoor temperatures in buildings and their urban environment are increasing every year, especially in hot climates, moving increasingly away from the desired comfort conditions. The scarcity of vegetation and the use of conventional materials in urban areas lead to a worsening of environmental conditions, feeding the urban heat island effect. It also affects indoor comfort, increasing electricity consumption for air conditioning and, consequently, greenhouse gas emissions. This work evaluates the impact of urban transformation on the thermal demand and comfort of adjacent buildings in an urban space. This is located in the Avenida Cruz Roja in Seville, the object of a real bioclimatic urban design intervention. For this purpose, the buildings involved are organized into clusters, assessing the impact on indoor demand and comfort of the different mitigation measures proposed in each cluster. In this way, adaptation to climate change not only provides the necessary conditions for citizens to enjoy life in the street again, but also benefits buildings, reducing their demand and increasing the comfort of their occupants.