A Systematic review for sudden cardiac death in hypertrophic cardiomyopathy patients with Myocardial Fibrosis: A CMR LGE Study

Abstract

Hypertrophic cardiomyopathy is unique and presents with myriad of clinical symptoms and signs affecting infants to the very old [1,4,5]. Most of the affected individuals probably have an uneventful life. However, in some patients with HCM the disease results in profound clinical implications including

Myocardial Fibrosis in Hypertrophic Cardiomyopathy: What Remains to be Proven?

“…This result is in accordance with another meta-analysis evaluating HCM and myocardial fibrosis, totaling 1,063 patients (mean follow-up of 43 ± 14 months), in which the presence of late enhancement in these patients resulted in a 9-fold higher chance of ventricular fibrillation / tachycardia and a 3.3-fold higher chance of SD. 10 These results suggest that late enhancement may be very useful as a high-risk prognostic marker.…”