A Systematic Review and Meta-Analysis of Circulating Biomarkers Associated with Failure of Arteriovenous Fistulae for Haemodialysis

Morton, Sarah; Rodríguez, Alexander J.; Morris, Dylan; Bhandari, Abhishta; Moxon, Joseph V.; Golledge, Jonathan

doi:10.1371/journal.pone.0159963

Cited by 23 publications

(19 citation statements)

References 29 publications

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“…22 Studies have clearly demonstrated the main pathophysiology underlying neointimal hyperplasia and atherosclerosis: inflammation. [23][24][25] Platelets play a significant role in both prothrombotic and proinflammatory events by contacting with endothelium and inducing cytokine secretion. 26 Besides, lowness of the lymphocyte number is proved to be an independent predictor of cardiovascular disease by taking part in the pathogenesis of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Relationship of arteriovenous fistula stenosis and thrombosis with the platelet–lymphocyte ratio in hemodialysis patients

2019

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Background: The platelet–lymphocyte ratio, which was reported to have a strong relationship with chronic inflammation and thrombosis, is a useful biomarker. The purpose of this study was to evaluate the relationship between the platelet–lymphocyte ratio, arteriovenous stenosis, and thrombosis in patients with chronic renal failure. Methods: Patients who were referred to our interventional radiology department due to arteriovenous fistula dysfunction from dialysis units between August 2015 and December 2018 were retrospectively reviewed. In the study, 95 patients with arteriovenous fistula access problems were included. Patients were divided into two groups: stenosis ( n = 52) and thrombosis ( n = 43). Thirty-six subjects with a patent left radiocephalic arteriovenous fistula proven by both color Doppler ultrasonography and clinically were added to the control group. Blood samples were obtained on the same day before the fistulography. Results: Platelet counts, lymphocyte counts, and platelet–lymphocyte ratio were found to be significantly different between the three groups. After the Bonferroni post hoc analysis, there was a significant difference between the stenosis and control group ( p = 0.017), and the thrombosis and control group ( p < 0.001) in terms of the platelet–lymphocyte ratio. No significant difference for any parameter was found between stenosis and thrombosis group. Conclusion: High levels of the platelet–lymphocyte ratio may be a supportive finding of arteriovenous fistula stenosis and thrombosis and can be taken into consideration during hemodialysis-dependent patients’ follow-up.

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Section: Discussionmentioning

confidence: 99%

Relationship of arteriovenous fistula stenosis and thrombosis with the platelet–lymphocyte ratio in hemodialysis patients

2019

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“…Studies suggest that inflammation causes neointimal hyperplasia, which results in thrombosis at the anastomotic site and is responsible for failure of the AVF. 4 , 12 , 13 ) Neointimal hyperplasia is pathologically similar to atherosclerosis. 14 ) Studies have clearly demonstrated that atherosclerosis is the main pathology in coronary occlusive disease, 6 ) bare metal stent failure 7 ) and autologous saphenous vein graft failure 8 ) ; and NLR has been shown as a strong independent predictor in all of these scenarios.…”

Section: Discussionmentioning

confidence: 99%

High Preoperative Neutrophil-Lymphocyte Ratio (NLR) and Red Blood Cell Distribution Width (RDW) as Independent Predictors of Native Arteriovenous Fistula Failure

Rashid

Jamil

Naveed

2017

Annals of Vascular Diseases

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Objective: To study the association between a high preoperative neutrophil lymphocyte ratio (NLR) and red cell distribution width (RDW) with arteriovenous fistula (AVF) failure, as well as to determine the cut-off values in a South Asian population. Materials and Methods: A total of 150 consecutive patients with a failed fistula who presented in the Department of Vascular Surgery between January 2014 and January 2016. Patients fulfilling the inclusion criteria were selected as defined as Case. They were compared with 150 patients who had matured fistulae (Control). Results: A significant difference was found between the Case and Control groups in mean preoperative NLR (3.3±0.5 versus 2.2±0.9, P value=0.011) and RDW (15.9±2.9 versus 13.6±1.1%, P value of 0.02), respectively. Multivariate analysis revealed that NLR (Odds Ratios (OR) 1.39; 95% Confidence Intervals (CI) 1.02 to 2.08; P<0.001) and RDW (OR 1.39; 95%CI 1.11 to 1.69; P<0.001) were strong independent predictors of AVF failure. A receiver operating characteristic curve analysis showed a cut-off value of 2.65 (specificity 80%, sensitivity 98%) and 15.1 (specificity 79%, sensitivity 98%) for NLR and RDW, respectively. Conclusion: Increased preoperative NLR and RDW were associated with a high rate of AVF failure in a South Asian population.

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“…thirteen different studies in their meta-analysis study (11) . At the end of the study, no relation was found between AVF thrombosis development and a total of twelve biochemical parameters including hemoglobin levels and C-reactive Research Article protein (CRP).…”

Section: Morton Et Al Have Evaluated 1512 Patients Frommentioning

confidence: 99%

A Research for Predictive Value of Hemogram Parameters at Late Term Arteriovenous Fistula Thrombosis Formation

Akkaya¹,

Bilen²

2019

ejcm

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This study aims to assess the relation between late term arteriovenous fistula thrombosis and alteration in hemogram parameters before the occurrence of thrombosis in hemodialysis patients with end-stage renal failure. Materials and Methods: Data of three hemodialysis centers in our city were evaluated retrospectively. The results of hemogram values before thrombosis formation at first and third month in 14 re-operated patients between March-September 2017, owing to late term fistula thrombosis occurrence, who previously had a successful fistula access, were compared to 73 patients still having hemodailysis therapy via fistula access. Results: Statistically significant increments were measured in neutrophile to lympocyte ratio, red blood cell distribution width, mean platelet volume, platelet distribution width parameters in fistula thrombosis developed patients compared to their previous results three months before thrombosis formation and control group. No significant relation was found between thrombosis formation and other parameters in hemogram. Conclusion: Herein, it's determined that a profound examination of hemogram has a predictive value for late term fistula thrombosis in hemodialysis patients.

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A Systematic Review and Meta-Analysis of Circulating Biomarkers Associated with Failure of Arteriovenous Fistulae for Haemodialysis

Cited by 23 publications

References 29 publications

Relationship of arteriovenous fistula stenosis and thrombosis with the platelet–lymphocyte ratio in hemodialysis patients

Relationship of arteriovenous fistula stenosis and thrombosis with the platelet–lymphocyte ratio in hemodialysis patients

High Preoperative Neutrophil-Lymphocyte Ratio (NLR) and Red Blood Cell Distribution Width (RDW) as Independent Predictors of Native Arteriovenous Fistula Failure

A Research for Predictive Value of Hemogram Parameters at Late Term Arteriovenous Fistula Thrombosis Formation

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