A systematic review and meta-analysis of the herbal formula Buzhong Yiqi Tang for stable chronic obstructive pulmonary disease

Chen, Yuanbin; Shergis, Johannah Linda; Wu, Lei; Yu, Xin; Zeng, Qigang; Xu, Yinji; Guo, Xinfeng; Zhang, Anthony Lin; Xue, Charlie Changli; Lin, Lin

doi:10.1016/j.ctim.2016.09.017

Cited by 28 publications

(23 citation statements)

References 21 publications

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“…Although several studies ( 24 ) demonstrated the efficacy of BZYQT on the 6MWD in stable patients with COPD, the addition of TJ-41 treatment to PR did not improve exercise capacity in patients with COPD in the current study. The reason for this discrepancy is unclear.…”

Section: Discussioncontrasting

confidence: 82%

“…The addition of TJ-41 treatment to PR may have beneficial effects on dyspnea scores and HRQOL scores in malnourished COPD patients. A previous meta-analysis ( 24 ) demonstrated the efficacy of the Chinese herbal medicine, Bu-Zhong-Yi-Qi-Tang (BZYQT), in patients with stable COPD. Many studies have examined the utility of drugs similar to TJ-41 in this population, but the benefits of TJ-41 in patients with stable COPD remain largely unexplored.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have examined the utility of drugs similar to TJ-41 in this population, but the benefits of TJ-41 in patients with stable COPD remain largely unexplored. The investigators in two studies reported that BZYQT improved CAT scores ( 24 ). Tatsumi et al ( 15 ) reported that after 6 months of treatment, the symptoms score on the St. George's Respiratory Questionnaire decreased in patients with COPD receiving TJ-41, but did not decrease in the control group.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Hochuekkito combined with pulmonary rehabilitation in patients with chronic obstructive pulmonary disease

et al. 2018

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Chronic obstructive pulmonary disease (COPD) has significant systemic effects, such as weight loss, which affects exercise capacity, health-related quality of life (HRQOL) and survival. The traditional herbal medicine, Hochuekkito (TJ-41), improves the nutritional status and decreases systemic inflammation in patients with COPD. However, to date, the additive effect of TJ-41 on pulmonary rehabilitation (PR) in patients with COPD has not been researched comprehensively. The purpose of the present study was to investigate the efficacy and safety of adding TJ-41 to PR for patients with COPD. Thirty-three malnourished patients with COPD were randomly assigned to receive low-intensity exercise with (TJ-41 group) or without (control group) TJ-41 treatment for 12 weeks. The primary outcome was the change in the 6-min walk distance (6MWD). Secondary outcomes included changes in the body composition, peripheral muscle strength, modified Medical Research Council dyspnea score, visual analog scale (VAS) score for dyspnea, VAS score for fatigue and COPD assessment test (CAT) score. After the 12-week treatment, body weight and percent ideal body weight were significantly increased in the TJ-41 group (P<0.05), but not in the control group. After the 12-week treatment, the modified Medical Research Council dyspnea score, VAS score for dyspnea, VAS score for fatigue and total CAT score decreased significantly in the TJ-41 group (all P<0.05), but not in the control group. There were no significant differences in the 6MWD and peripheral muscle strength between baseline and after 12 weeks of treatment in either group. No adverse effects were noted with the use of TJ-41. It was concluded that the addition of TJ-41 to PR may benefit malnourished patients with COPD with respect to dyspnea and HRQOL.

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Section: Discussioncontrasting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of Hochuekkito combined with pulmonary rehabilitation in patients with chronic obstructive pulmonary disease

et al. 2018

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“…The report also showed the multiple effects of medicinal plants on ischemic stroke including the protective role and recovery against injury [ 65 ]. Buzhong Yiqi is a herbal formula used for treating various conditions [ 66 ] such as muscle atrophy, whereby the decoction can downregulate nuclear receptor corepressor 1 and its downstream factors [ 67 ]. Mitochondrial oxidative metabolism was identified as the mechanism underlying the Buzhong Yiqi-mediated recovery of muscle quantity [ 67 ].…”

Section: Pharmacological Action Of Plants Tested Using In Vivo Andmentioning

confidence: 99%

Proteomic Contributions to Medicinal Plant Research: From Plant Metabolism to Pharmacological Action

2017

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Herbal medicine is a clinical practice of utilizing medicinal plant derivatives for therapeutic purposes. It has an enduring history worldwide and plays a significant role in the fight against various diseases. Herbal drug combinations often exhibit synergistic therapeutic action compared with single-constituent dosage, and can also enhance the cytotoxicity induced by chemotherapeutic drugs. To explore the mechanism underlying the pharmacological action of herbs, proteomic approaches have been applied to the physiology of medicinal plants and its effects on animals. This review article focuses on the existing proteomics-based medicinal plant research and discusses the following topics: (i) plant metabolic pathways that synthesize an array of bioactive compounds; (ii) pharmacological action of plants tested using in vivo and in vitro studies; and (iii) the application of proteomic approaches to indigenous plants with scarce sequence information. The accumulation of proteomic information in a biological or medicinal context may help in formulating the effective use of medicinal plants.

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“…Recent surveys reported that traditional Chinese medicine is effective in relieving clinical symptoms, improving lung function, reducing inflammation, shortening acute exacerbation, and improving quality of life [ 9 – 12 ]. Moreover, it has an excellent safety profile [ 11 ]. Chinese herbal injection (CHI) is an innovative formulation with high bioavailability and rapid action [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta‐Analysis of Randomized Controlled Trials

Duan

Huang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Introduction Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) imposes a huge economic burden on healthcare systems worldwide. Chinese herbal injections (CHIs) are widely used to treat AECOPD. In this study, we examined the efficacy of CHIs in the treatment of AECOPD using a network meta-analysis (NMA). Methods Literature search was conducted from electronic databases of randomized controlled trials (RCTs) on CHIs plus Western medicine (WM) versus WM. WinBUGS 1.4.3 and STATA 12.0 were adopted to compute calculations and prepare graphs, respectively. Results We included 155 RCTs with 13,218 patients. The results revealed that Danhong injection (DH) + WM had the greatest therapeutic potential in terms of rate of clinical efficacy (RCE). In addition, in comprehensively improving RCE and FEV1%, and RCE and C-reactive protein, Huangqi injection (HQ) +WM was associated with preferable effects. Similarly, Xixinnao injection + WM, Reduning injection (RDN) +WM, and HQ+WM had a favorable effect on RCE and PaO2. The effect of RDN+WM was favorable in all outcomes except RCE. The safety of CHIs needs to be further assessed. Conclusions Based on this NMA, DH+WM, HQ+WM, and RDN+WM were potential optimal therapies in AECOPD and their safety should be strictly monitored.

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A systematic review and meta-analysis of the herbal formula Buzhong Yiqi Tang for stable chronic obstructive pulmonary disease

Cited by 28 publications

References 21 publications

Effects of Hochuekkito combined with pulmonary rehabilitation in patients with chronic obstructive pulmonary disease

Effects of Hochuekkito combined with pulmonary rehabilitation in patients with chronic obstructive pulmonary disease

Proteomic Contributions to Medicinal Plant Research: From Plant Metabolism to Pharmacological Action

Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta‐Analysis of Randomized Controlled Trials

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