A Systematic Review and Meta-analysis of the Clinical and Epidemiological Characteristics of Patients with Hypertensive Emergencies: Implication for Risk Stratification

Benenson, Irina; Waldron, Frederick A; Holly, Cheryl

doi:10.1007/s40292-023-00586-1

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…In contrast, in the case of PLMS the use of SSRIs led to an increase in the PLMS index (Ferri et al, 2023); however, EFM and PLMS must not be directly compared with each other. In conclusion, older age, being male, having higher PLMS/PLMW indices explain the increase in the FMI but, e.g., age and male gender are per se associated with an increased cardiovascular disease (Benenson et al, 2023).…”

Section: Discussionmentioning

confidence: 79%

A 24% prevalence of excessive fragmentary myoclonus in 500 consecutive sleep laboratory patients

Bergmann,

Stefani,

Ibrahim

et al. 2023

Journal of Sleep Research

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SummaryExcessive fragmentary myoclonus (EFM) is a frequent finding during routine video‐polysomnography (VPSG). We aimed to automatically measure the prevalence of EFM according to current American Academy of Sleep Medicine (AASM) criteria, and the fragmentary myoclonus index (FMI) in sleep stage N1, N2, N3, rapid eye movement (REM) sleep and wake in a large patient population. A total of 500 VPSG recordings of patients admitted to the Sleep Laboratory, Department of Neurology, Medical University of Innsbruck, Austria, between May 1, 2022 and February 28, 2023, were included. EFM according to AASM criteria and FMI were computed by applying a previously validated algorithm. EFM was automatically detected in 121 of the 500 Sleep Laboratory patients (24.2%, 95% confidence interval 20.1%–28.9%). FMI increased with age, male gender, apnea–hypopnea‐index (AHI), oxygen desaturation index (ODI), and periodic leg movements of sleep (PLMS) index. FMI was highest in REM sleep behaviour disorder (RBD), followed by neurodegenerative and internal medicine diseases, but the increase in the FMI was not explained by the disease itself but rather by the age and sex of the patients. Almost a quarter of our patient population had EFM. However, the prevalence of EFM does not allow the drawing of any conclusions about the pathophysiology of EFM or even the determination of a pathological FMI cut‐off value. Associations of the FMI with age, sex, AHI, ODI and PLMS are in line with previous studies, but the FMI needs to be evaluated in different disease entities to learn more about its pathophysiology.

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Section: Discussionmentioning

confidence: 79%

A 24% prevalence of excessive fragmentary myoclonus in 500 consecutive sleep laboratory patients

Bergmann,

Stefani,

Ibrahim

et al. 2023

Journal of Sleep Research

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Hypertensive crisis and its predictors in Africa: Systematic review and meta-analysis, 2024

Adal,

Kebede,

Delie

et al. 2024

International Journal of Cardiology Cardiovascular Risk and Pre

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Evaluation and management of hypertensive emergency

Miller,

Hrabec,

Krishnamoorthy

et al. 2024

BMJ

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Hypertensive emergencies cause substantial morbidity and mortality, particularly when acute organ injury is present. Careful and effective strategies to reduce blood pressure and diminish the effects of pressure-mediated injury are essential. While the selection of specific antihypertensive medications varies little across different forms of hypertensive emergencies, the intensity of blood pressure reduction to the target pressure differs substantially. Treatment hinges on balancing the positive effects of lowering blood pressure with the potential for negative effects of organ hypoperfusion in patients with altered autoregulatory mechanisms. When patients do not have acute organ injury in addition to severe hypertension, they benefit from a conservative, outpatient approach to blood pressure management. In all cases, long term control of blood pressure is paramount to prevent recurrent hypertensive emergencies and improve overall prognosis. This review discusses the current evidence and guidelines on the evaluation and management of hypertensive emergency.

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A Systematic Review and Meta-analysis of the Clinical and Epidemiological Characteristics of Patients with Hypertensive Emergencies: Implication for Risk Stratification

Cited by 3 publications

References 46 publications

A 24% prevalence of excessive fragmentary myoclonus in 500 consecutive sleep laboratory patients

A 24% prevalence of excessive fragmentary myoclonus in 500 consecutive sleep laboratory patients

Hypertensive crisis and its predictors in Africa: Systematic review and meta-analysis, 2024

Evaluation and management of hypertensive emergency

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