A systematic review and meta-analysis of seroprevalence of varicella zoster virus: A nationwide population-based study

Amjadi, Omolbanin; Rafiei, Alireza; Haghshenas, Mohammadreza; Alizadeh‐Navaei, Reza; Valadan, Reza; Hosseini‐Khah, Zahra; Omran, Akbar Hedayatizadeh; Arabi, Mohsen; Shakib, Reza Jafari; Mousavi, Tahoora; Ashrafi, G. Hossein

doi:10.1016/j.jcv.2016.12.001

Cited by 26 publications

(22 citation statements)

References 43 publications

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“…The present study found that a certain proportion of young adults (20-29 years old) was susceptible to varicella. The age-speci c seropositivity of varicella in this study was similar to previous ndings from Spain, Switzerland, and Iran [18][19][20]. The disease burden of varicella in Vietnam is not well known, but varicella is one cause of central nervous system infections in northern [6] and southern Vietnam [7].…”

Section: Mumpssupporting

confidence: 87%

Population immunity to measles, rubella, mumps, and varicella among adults in Khanh Hoa province, Socialist Republic of Vietnam; residual sample analysis from multistage cluster sampling survey

Thai¹,

Huynh²,

Vien³

et al. 2020

Preprint

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Objective: Measles, rubella, mumps, and varicella are currently endemic in Vietnam, but population immunity to the four diseases among the general population has not been well investigated. This study measured specific immunoglobulin (Ig)G in 362 randomly selected adults between 20 and 70 years old, using residual serum samples to evaluate age-specific immunity to the four diseases in Khanh Hoa province.Results: Age-specific anti-measles IgG prevalence was lowest, at 89.3% (95% confidence interval 71.8–97.7%) at 20–24 years old, below the herd immunity threshold of 95% to prevent epidemics. About 71.4–90.3% of women of child-bearing age (20–49 years old) were seropositive for rubella, indicating that a certain proportion of babies are at risk of congenital rubella syndrome. A large proportion of young adults (20–29 years) are susceptible to mumps and varicella, with population immunity of 71.4–78.1% to mumps and 48.8–53.6% to varicella. Population-based seroprevalence surveys of both children and adults are needed to evaluate population immunity and improve current immunization programs by expanding the target ages for immunization and introducing new vaccines.

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Section: Mumpssupporting

confidence: 87%

Population immunity to measles, rubella, mumps, and varicella among adults in Khanh Hoa province, Socialist Republic of Vietnam; residual sample analysis from multistage cluster sampling survey

Thai¹,

Huynh²,

Vien³

et al. 2020

Preprint

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“…The incidence of VZV in women was also higher than that in men, and the difference increased with age. Compared with Amjadi et al (Amjadi, 2017), the prevalence rate of VZV in Chinese women was 62.71%, which was lower than that in Iranian women (80.47%). Dong Yanhong et al (Dong, 2017) found that the VZV prevalence of the elderly that was 96.56% in Chaoyang District of Beijing was slightly higher than that of 95.30% in Iran.…”

Section: Figure 4 Forest Plots Of Vzv Prevalence In Different Genderscontrasting

confidence: 73%

Seroprevalence of Varicella Zoster virus in China: an age-stratifed systematic review and meta-analysis

Wang

Sun

et al. 2019

Preprint

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OBJECTIVES: the aim of this meta-analysis was pooled on the comprehensive information of the epidemiology of VZV infection and analyzed the seropositivity of VZV-IgG antibodies in different age groups in China, so as to arouse people's attention on VZV. DESIGN: Systematic review DATA SOURCES: Sources included on PubMed, the China National Knowledge Infrastructure (CNKI) database, WANFANG database and the Chinese Scientific Journals Full-Text Database (CQVIP) from 1997 to 2019. ELIGIBILITY CRITERIA: (1) the Chinese and English literatures of study on varicella-zoster virus immunization epidemics in different regions of China; (2) The literature has obvious age stratification; (3) The subjects are general people; (4) VZV sero-prevalence in the population investigated by the literature research institute. Exclusion criteria: Any study that did not contain these information was excluded. DATA EXTRACTION AND SYNTHESIS: Two evaluators independently retrieved documents and extracted data. Information about the study design, eligible population, age and gender distribution, inclusion and exclusion criteria were checked. When they disagreed, they could solve the problem by discussion or by soliciting opinions from third parties. RESULTS: Literatures were screened according to the inclusion criteria and 10 studies from 1997 to 2019 with a total of 11666 individuals were included. The overall VZV seroprevalence in the Chinese population was 65.80% (95% CI; 56.5% - 75.1%), and the peak prevalence was seen in the age 36-45 93.50% (95% CI; 0.917-0.953) while the VZV seroprevalence rate (82.20%, 95% CI: 0.544-1.099) was not increased in individuals of 45 and older. CONCLUSION: The incidence of VZV increases with age, and there was no significant difference between different genders or regions. This results can provide epidemiological evidence for the prevention and treatment of VZV.

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“…This study’s findings confirm previous reports that single-dose varicella vaccine is insufficient to provide the population with an immune barrier. Based on varicella surveillance and seroprevalence data, it was found that there was a negative correlation between the reported incidence and seroprevalence among regions, which indirectly indicated that the immunization effect of varicella vaccine could prevent the spread of varicella to a certain extent [ 20 ]. The state of the varicella epidemic is the most serious and the seroprevalence of antibody in children is the lowest in the southern Jiangsu region, meaning that the occurrence of varicella virus infection in this region can easily cause an epidemic outbreak of varicella.…”

Section: Discussionmentioning

confidence: 99%

Analysis of sero-epidemiological characteristics of varicella in healthy children in Jiangsu Province, China

Zhang

Liu

et al. 2018

BMC Infect Dis

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BackgroundIn recent years, outbreaks of varicella have continued to occur, and the coverage rate of varicella vaccine in Jiangsu Province, China, remains unclear. This study aims to analyse the levels of immune antibody against varicella and obtain a comprehensive understanding of the varicella attenuated live vaccine (VarV) coverage rate in children aged 1–9 years in Jiangsu Province.MethodsFrom June to October 2016, a cross-sectional survey was conducted to collect 3631 serum samples from healthy children aged 1–9 years in Jiangsu Province. The immunoglobulin G (IgG) antibody levels of varicella were detected by enzyme-linked immunosorbent assay (ELISA).ResultsThe VarV coverage rate of healthy children was only 43.1% (95% CI: 41.1–44.7%). The seroprevalence after vaccination with a single dose of VarV was only 57.1%, and the overall seropositivity and geometric antibody titre (GMC) were 43.5% and 225.4 mU/ml, respectively. The seropositivity was significantly higher in girls than in boys (χ2 = 18.82, P < 0.001). The difference in seropositivity between the 5–9 age group and 1–4 age group was statistically significant (χ2 = 84.31, P < 0.001). The difference in seropositivity between different regions was statistically significant, with the highest seropositivity in the northern area, 53.7% (χ2 = 35.64, P < 0.001). The seropositivity in the group receiving one dose of VarV was significantly higher than that of the unvaccinated group (χ2 = 205.16, P < 0.001). Linear regression analysis suggested that the GMC of varicella antibodies wanes with the time since vaccination (F = 65.01, P = 0.002).ConclusionThe VarV coverage rate of healthy children in Jiangsu Province was low. Sero-conversion rates were also low after one dose of VarV, and the immune effectiveness of a single dose of VarV was limited. To control the spread of varicella, VarV should be included in the routine immunization program, and strengthened immunization measures for the varicella-susceptible population warrant additional consideration.

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A systematic review and meta-analysis of seroprevalence of varicella zoster virus: A nationwide population-based study

Cited by 26 publications

References 43 publications

Population immunity to measles, rubella, mumps, and varicella among adults in Khanh Hoa province, Socialist Republic of Vietnam; residual sample analysis from multistage cluster sampling survey

Population immunity to measles, rubella, mumps, and varicella among adults in Khanh Hoa province, Socialist Republic of Vietnam; residual sample analysis from multistage cluster sampling survey

Seroprevalence of Varicella Zoster virus in China: an age-stratifed systematic review and meta-analysis

Analysis of sero-epidemiological characteristics of varicella in healthy children in Jiangsu Province, China

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