A systematic review and meta‐analysis of familial prostate cancer risk

Abstract

calculating the weighted average of the log relative risk (RR) estimates from studies. RESULTSThe pooled RR (95% confidence interval) in first-degree relatives was 2.5 (2.2-2.8). There was evidence that this was highest in relatives of cases diagnosed before age 60 years and that RRs declined with age. The risk for the few men with two affected relatives was increased 3.5-fold (2.6-4.8). RRs to sons of cases appeared to be lower than in brothers; a complete explanation of this observation is uncertain. CONCLUSIONMen with a family history of prostate cancer have a significantly greater risk of developing prostate cancer than those with no such history. Risks are greatest for relatives of cases diagnosed when young and those with more than one relative affected. KEYWORDSprostate cancer, familial risk, meta-analysis OBJECTIVETo identify published studies quantifying familial prostate cancer risks in relatives of prostate cancer cases and, by meta-analysis, obtain more precise estimates of familial risk according to the family history.

Family history of prostate cancer and prostate cancer risk in the Alpha‐Tocopherol, Beta‐Carotene Cancer Prevention (ATBC) Study

“…Several 2,21,30,35 but not all, 22 studies have found that a history of prostate cancer in a sibling confers greater risk than that of paternal history, which would be consistent with the additional contribution to risk of a shared environment in childhood and adolescence. We observed a somewhat stronger association with paternal history, although the number of cases was small, and the confidence intervals for paternal versus sibling history were not mutually exclusive.…”

“…A recent meta-analysis estimated that a family history of prostate cancer in first-degree relatives was associated with a relative risk of 2.5 [3.5 for risk of early onset (<60 years old) disease]. 2 However, most existing studies are limited to retrospective case-control studies [3][4][5][6][7] and some existing cohort studies are based on family history probands. [8][9][10] Additionally, 2 prospective studies reported that associations between body mass index and prostate cancer were more pronounced among men with a positive family history, 11,12 but data evaluating interactions with other important prostate cancer risk factors are limited.…”

The significance of biological, environmental, and social risk factors for prostate cancer in a cohort study in Brazil

“…Ample epidemiologic evidence suggests that prostate cancer has both a familial and genetic component (1). In one meta-analysis, the pooled risk of prostate cancer was higher in men who had a father or brother affected by prostate cancer, compared to a control population with no affected relatives (RR 2.5, 95%CI 2.2-2.8) (14). Another meta-analysis showed an increased risk of prostate cancer for any affected family member (RR 2.04, 95%CI 1.64-2.55), a higher risk for disease for affected fi rst-degree relatives (RR 2.24, 95%CI 2.08-2.41), and an elevated risk of cancer in affected second-degree relatives (RR 1.91, 95%CI 1.58-2.30) (15).…”

Correlação entre exposição ao óxido de etileno e câncer de próstata: doença ocupacional?

“…Os 22 , mas nenhum estudo até a presente data foi conclusivo [8][9][10][22][23][24] . O risco de desenvolvimento de doença neoplásica maligna associada à exposição ao OEt não pode, até a presente data, ser confirmado.…”

“…Em relação à etnia, os afroamericanos têm maior risco de desenvolver a doença, entre dez a quarenta vezes mais que os asiáticos 6,7 . Parentes de primeiro grau de sujeitos com CP apresentam de duas a três vezes mais chance de ter a doença, quando comparados a homens na população geral 8,9 . A dieta altamente calórica e os hormônios masculinos também são fatores de risco 10,11 .…”