A systematic review and meta-analysis on the impact of pre-existing and new-onset atrial fibrillation on outcomes before and after liver transplantation

So, Wei Zheng; Tan, Felicia Liying; Tan, Darren Jun Hao; Ng, Cheng Han; Yong, Jie Ning; Tang, Ansel Shao Pin; Wong, Raymond; Lin, Weiqin; Tan, Eunice Xiang Xuan; Huang, Daniel Q.; Dan, Yock Young; Chew, Nicholas; Siddiqui, Mohammad Shadab; Muthiah, Mark

doi:10.1016/j.dld.2021.11.011

Cited by 11 publications

(14 citation statements)

References 62 publications

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“… 11 Postoperative AF following liver transplantation has been shown to prolong the length of hospital stay, increase the incidence of acute kidney injury and the incidence of graft failure at 1 year, and was shown to be an independent risk factor for post liver-transplant mortality. 12 – 14 Postoperative AF was also associated with an 8-fold increased risk of stroke and systemic embolism events over a median follow-up of 4.9 years. 15 …”

Section: Discussionmentioning

confidence: 98%

New onset atrial fibrillation during orthotopic liver transplantation induced by iced saline injection for transpulmonary thermodilution: a case report

Wang

Guo

2022

J Int Med Res

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Transpulmonary thermodilution is often used to measure extravascular lung water during liver transplantation. Here, the case of new onset atrial fibrillation during orthotopic liver transplantation, which may have been induced by iced saline injection for transpulmonary thermodilution measurement, is described. A 52-year-old male patient underwent orthotopic liver transplantation due to alcoholic cirrhosis combined with portal hypertension. During dissection of the recipient liver, transpulmonary thermodilution was performed. At 3 minutes following iced saline injected, atrial fibrillation occurred, the ventricular rate increased to more than 120 beats per min, and blood pressure dropped to 75/50 mmHg. Massive haemorrhage, inferior vena cava clamping, electrolyte disorder, acid-base balance disorder, and hypothermia were all ruled out, and iced saline injection was suspended. Hemodynamic stability was maintained with phenylephrine and lanatocide C (cedilanid), and chemical cardioversion was performed using amiodarone. During the reperfusion phase, transient hemodynamic instability was managed by norepinephrine. The neohepatic phase was uneventful. Atrial fibrillation lasted for 5 days and reversed to sinus rhythm automatically. The patient was hemodynamically stable during this period, and recovery was smooth with no thromboembolic events. In conclusion, atrial fibrillation may be induced by iced saline injection for transpulmonary thermodilution measurement during orthotopic liver transplantation.

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Section: Discussionmentioning

confidence: 98%

New onset atrial fibrillation during orthotopic liver transplantation induced by iced saline injection for transpulmonary thermodilution: a case report

Wang

Guo

2022

J Int Med Res

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“…They concluded that A-fib is relatively common before and after adult LT, which is associated with adverse outcomes. 46 A recent shift in the ESLD etiologies for adult patients undergoing LT has resulted in an increasing prevalence of CAD. Xiao and associates performed a systematic review and meta-analysis using 39 studies evaluating the prevalence of pre-LT CAD, risk factors, and outcomes.…”

Section: Cardiovascular Topicsmentioning

confidence: 99%

“…Prevalence and impact of A-fib for LT: So, et al 46 The pooled analysis of 45,070 patients in 14 studies showed that the prevalence of pre-existing A-fib was 3.3%, which was associated with major adverse cardiac or cerebrovascular events postoperatively (OR 8.02). New-onset A-fib after LT had an incidence of 6.8% with risk of mortality (OR 2.31).…”

Section: Liver Transplantationmentioning

confidence: 99%

“…Atrial fibrillation (A-fib) is the most diagnosed cardiac arrhythmia for adult patients with end-stage liver disease (ESLD) undergoing LT. A-fib for LT patients is associated with significant morbidity and mortality. So et al 46 performed a systematic literature review on the impact of pre-existing and new-onset A-fib on outcomes before and after LT. 46 Their pooled analysis of 45,070 patients in 14 studies showed that the prevalence of pre-existing A-fib was 3.3% (95% CI 2.3–4.7). BMI, history of hypertension, diabetes, coronary artery disease (CAD), and cerebrovascular accidents were risk factors for pre-existing A-fib.…”

Section: Liver Transplantation (Table 2)mentioning

confidence: 99%

“…They concluded that A-fib is relatively common before and after adult LT, which is associated with adverse outcomes. 46…”

Section: Liver Transplantation (Table 2)mentioning

confidence: 99%

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Abdominal Organ Transplantation: Noteworthy Literature in 2021

Jules

Blech

Sakai

2022

Semin Cardiothorac Vasc Anesth

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This review highlights noteworthy literature pertinent to anesthesiologists and critical care physicians caring for patients undergoing abdominal organ transplantation. In 2021, we identified noteworthy papers from over 1,200 peer-reviewed publications on pancreatic transplantation, over 1,400 on intestinal transplantation, and over 9,000 on kidney transplantation. The liver transplantation section focuses on clinical trials and systematic reviews and meta-analyses published in 2021 and features 20 selected papers. COVID-19 and abdominal organ transplantation are featured in an independent section.

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Pre-transplant Cardiovascular Risk Assessment and Modification

Crespo

VanWagner

2022

Curr Treat Options Gastro

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A systematic review and meta-analysis on the impact of pre-existing and new-onset atrial fibrillation on outcomes before and after liver transplantation

Cited by 11 publications

References 62 publications

New onset atrial fibrillation during orthotopic liver transplantation induced by iced saline injection for transpulmonary thermodilution: a case report

New onset atrial fibrillation during orthotopic liver transplantation induced by iced saline injection for transpulmonary thermodilution: a case report

Abdominal Organ Transplantation: Noteworthy Literature in 2021

Pre-transplant Cardiovascular Risk Assessment and Modification

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