A systematic review and meta‐analysis of fetal outcomes following the administration of influenza A/H1N1 vaccination during pregnancy

Zhang, Chuan; Wang, Xiaodong; Liú, Dan; Zhang, Lingli; Sun, Xin

doi:10.1002/ijgo.12394

Cited by 25 publications

(23 citation statements)

References 42 publications

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“…However, between 1997 and 2004 only women in the second and third trimesters were advised to be vaccinated for influenza [ 9 , 43 , 44 ] resulting in limited information on exposures and outcomes like SAB in the first trimester [ 7 , 8 , 10 , 11 , 20 , 45 , 46 ]. More recently, studies and systematic reviews investigating pH1N1-containing vaccines have not identified excess risks of adverse events [ 3 , 12 , 13 , 15 , 18 , 40 , 47 – 49 ]. Overall, evidence to support the safety of influenza vaccine in pregnant women is substantial.…”

Section: Discussionmentioning

confidence: 99%

Inactivated influenza vaccine and spontaneous abortion in the Vaccine Safety Datalink in 2012–13, 2013–14, and 2014–15

Donahue

Kieke

King

et al. 2019

Vaccine

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Introduction: A recent study reported an association between inactivated influenza vaccine (IIV) and spontaneous abortion (SAB), but only among women who had also been vaccinated in the previous influenza season. We sought to estimate the association between IIV administered in three recent influenza seasons and SAB among women who were and were not vaccinated in the previous influenza season. Methods: We conducted a case-control study over three influenza seasons (2012–13, 2013–14, 2014–15) in the Vaccine Safety Datalink (VSD). Cases (women with SAB) and controls (women with live births) were matched on VSD site, date of last menstrual period, age group, and influenza vaccination status in the previous influenza season. Of 1908 presumptive cases identified from the electronic record, 1236 were included in the main analysis. Administration of IIV was documented in several risk windows, including 1–28, 29–56, and >56 days before the SAB date. Results: Among 627 matched pairs vaccinated in the previous season, no association was found between vaccination in the 1–28 day risk window and SAB (adjusted odds ratio (aOR) 0.9; 95% confidence interval (CI) 0.6–1.5). The season-specific aOR ranged from 0.5 to 1.7 with all CIs including the null value of 1.0. Similarly, no association was found among women who were not vaccinated in the previous season; the season-specific aOR in the 1–28 day risk window ranged from 0.6 to 0.7 and the 95% CI included 1.0 in each season. There was no association found between SAB and influenza vaccination in the other risk windows, or when vaccine receipt was analyzed relative to date of conception. Conclusion: During these seasons we found no association between IIV and SAB, including among women vaccinated in the previous season. These findings lend support to current recommendations for influenza vaccination at any time during pregnancy, including the first trimester.

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Section: Discussionmentioning

confidence: 99%

Inactivated influenza vaccine and spontaneous abortion in the Vaccine Safety Datalink in 2012–13, 2013–14, and 2014–15

Donahue

Kieke

King

et al. 2019

Vaccine

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“…The rst choice was meropenim because it has the pregnant category B. The patient was immunized by H1N1 vaccine as it is recommended from many studies with safe effects for mom and natal after birth [16,17].…”

Section: Discussionmentioning

confidence: 99%

Severe Pneumonia Associated With (H1N1) in a Pregnant Young Woman

Alduihi

2020

Preprint

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H1N1 is an acute infection that can affect any person any age as all viral infections, but it may be more aggressive in pregnant women. It may require admission to the ICU, and it carries many complications, pre-partum delivery, a severe state and even death if not treated immediately. H1N1 can correlate with a co-infection with bacterial pneumonia, and carries poor prognosis to morbidity and mortality. It needs a correlation of antibiotics and anti-swan treatment, and it needs a high intensity of clinician because, the diagnosis of H1N1 may be misleading in such cases. This case of a 14-year-old nonsmoker, a young pregnant woman, presented to the emergency department with gynecological hemorrhage 2 days prior. She was admitted to the obstetrics department and developed severe breathlessness, chest pain and nonproductive cough through hospitalization. After taking a throat swap, she was diagnosed with H1N1. She was treated with oseltamivir and antibiotics, and suspected coauthor bacterial pneumonia.

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“…Overall, it has been established that vaccinating pregnant women is safe, with no evidence demonstrating a link between immunization during pregnancy and adverse outcomes in offspring [159][160][161][162][163][164][165]. Infants born to mothers who were vaccinated against influenza may have a decreased rate of preterm birth, low birthweight, and stillborn birth, although establishing a causal relationship is challenging [160,[166][167][168][169][170][171]. Infants born to mothers who were severely sick with H1N1 influenza infection have been shown to have an increased risk of preterm birth, decreased 5 min Apgar scores, and an increased risk of death [172][173][174].…”

Section: A Key Role For Maternal Vaccination In Protecting Young Infamentioning

confidence: 99%

Influenza Virus and Vaccination

2020

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Influenza virus infections represent a serious public health problem causing contagious respiratory disease and substantial morbidity and mortality in humans, resulting in a considerable economic burden worldwide. Notably, the number of deaths due to influenza exceeds that of any other known pathogen. Moreover, influenza infections can differ in their intensity, from mild respiratory disease to pneumonia, which can lead to death. Articles in this Special Issue have addressed different aspects of influenza in human health, and the advances in influenza research leading to the development of better therapeutics and vaccination strategies, with a special focus on the study of factors associated with innate or adaptive immune responses to influenza vaccination and/or infection.

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A systematic review and meta‐analysis of fetal outcomes following the administration of influenza A/H1N1 vaccination during pregnancy

Abstract: The administration of H1N1 vaccines during pregnancy might reduce the risk of stillbirth, a complication associated with H1N1 infection. The quality of evidence was, however, not adequate to reach a definitive conclusion.

Cited by 25 publications

References 42 publications

Inactivated influenza vaccine and spontaneous abortion in the Vaccine Safety Datalink in 2012–13, 2013–14, and 2014–15

Inactivated influenza vaccine and spontaneous abortion in the Vaccine Safety Datalink in 2012–13, 2013–14, and 2014–15

Severe Pneumonia Associated With (H1N1) in a Pregnant Young Woman

Influenza Virus and Vaccination

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