A systematic review and meta-analysis of 18F-fluoro-d-deoxyglucose positron emission tomography interpretation methods in vascular graft and endograft infection

Folmer, Eline I. Reinders; Meijenfeldt, Gerdine C.I. von; Scholten, Renske S. te Riet ook genaamd; Laan, Maarten J. van der; Glaudemans, Andor W.J.M.; Slart, Riemer H. J. A.; Zeebregts, Clark J.; Saleem, Ben R.

doi:10.1016/j.jvs.2020.05.065

Cited by 29 publications

(28 citation statements)

References 35 publications

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“…LVAD infections are diagnostically challenging and difficult to treat, as source culture and source control (device removal) may not be easily possible. Similarly, it may also have a key role in diagnosing vascular graft infection (VGI)—both native vessel and endoprosthesis—for which it has high pooled sensitivity (>90%) and moderate-to-high pooled specificity (59–81%) [ 72 , 73 , 74 , 75 ].…”

Section: Nuclear Imagingmentioning

confidence: 99%

Contemporary Review of Multi-Modality Cardiac Imaging Evaluation of Infective Endocarditis

Arockiam

Agrawal

Dahdah

et al. 2023

Life

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Infective endocarditis (IE) remains to be a heterogeneous disease with high morbidity and mortality rates, which can affect native valves, prosthetic valves, and intra-cardiac devices, in addition to causing systemic complications. The combination of clinical, laboratory, and cardiac imaging evaluation is critical for early diagnosis and risk stratification of IE. This can facilitate timely medical and surgical management to improve patient outcomes. Key imaging findings for IE include vegetations, valve perforation, prosthetic valve dehiscence, pseudoaneurysms, abscesses, and fistulae. Transthoracic echocardiography continues to be the first-line imaging modality of choice, while transesophageal echocardiography subsequently provides an improved structural assessment and characterization of lesions to facilitate management decision in IE. Recent advances in other imaging modalities, especially cardiac computed tomography and 18F-fluorodeox-yglucose positron emission tomography, and to a lesser extent cardiac magnetic resonance imaging and other nuclear imaging techniques, have demonstrated important roles in providing complementary IE diagnostic and prognostic information. This review aims to discuss the individual and integrated utilities of contemporary multi-modality cardiac imaging for the assessment and treatment guidance of IE.

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Section: Nuclear Imagingmentioning

confidence: 99%

Contemporary Review of Multi-Modality Cardiac Imaging Evaluation of Infective Endocarditis

Arockiam

Agrawal

Dahdah

et al. 2023

Life

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“…Also, it detects radiolabeled leukocyte uptake by white blood cell (WBC) scintigraphy based on the capacity of a radiolabeled granulocyte to reach the infection site and to accumulate in infectious tissues. WBC scintigraphy together with single-photon emission computed tomography (SPECT/CT) seems to increase diagnostic power [21,[84][85][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103].…”

Section: Diagnosismentioning

confidence: 99%

“…cell (WBC) scintigraphy based on the capacity of a radiolabeled granulocyte to reach the infection site and to accumulate in infectious tissues. WBC scintigraphy together with single-photon emission computed tomography (SPECT/CT) seems to increase diagnostic power [21,[84][85][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103]. The importance of MAGIC criteria, which are also recommended in the current guidelines [22], lies in the provided definition of classic and definite cases that can be managed with high sensitivity and specificity.…”

Section: Diagnosismentioning

confidence: 99%

Infection of Vascular Prostheses: A Comprehensive Review

et al. 2023

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Vascular graft or endograft infection (VGEI) is a complex disease that complicates vascular-surgery and endovascular-surgery procedures and determines high morbidity and mortality. This review article provides the most updated general evidence on the pathogenesis, prevention, diagnosis, and treatment of VGEI. Several microorganisms are involved in VGEI development, but the most frequent one, responsible for over 75% of infections, is Staphylococcus aureus. Specific clinical, surgical, radiologic, and laboratory criteria are pivotal for the diagnosis of VGEI. Surgery and antimicrobial therapy are cornerstones in treatment for most patients with VGEI. For patients unfit for surgery, alternative treatment is available to improve the clinical course of VGEI.

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“…Although there is a tendency from open surgery to more endovascular procedures, vascular graft and endograft infection (VGEI) still occurs in approximately up to 6% of all vascular graft replacements [1,2]. Early postoperative infections mainly occur due to intraoperative contamination or a direct progression of a wound infection to the graft, while VGEI occurring a long time after surgery is considered to be a result of the reactivation of a previously undetected infection of the graft or seeding of the graft due to bacteraemia [3].…”

Section: Introductionmentioning

confidence: 99%

Added Value of Abnormal Lymph Nodes Detected with FDG-PET/CT in Suspected Vascular Graft Infection

Rijsewijk

Helthuis

Glaudemans

et al. 2023

Biology

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Vascular graft and endograft infections (VGEI) cause a serious morbidity and mortality burden. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging is frequently used in the diagnostic workup, but the additional value of abnormal (18F-FDG active and/or enlarged) locoregional lymph nodes is unknown. In this retrospective study, the additional diagnostic value of abnormal locoregional lymph nodes on 18F-FDG PET/CT imaging for VGEI was evaluated, including 54 patients with a culture-proven VGEI (defined according to the Management of Aortic Graft Infection [MAGIC] group classification) and 25 patients without VGEI. 18F-FDG PET/CT was qualitatively and quantitatively assessed for tracer uptake and pattern at the location of the vascular graft, and locoregional lymph node uptake and enlargement (>10 mm). 18F-FDG uptake intensity and pattern independently predicted the presence of VGEI by logistic regression (Χ2: 46.19, p < 0.001), with an OR of 7.38 (95% CI [1.65, 32.92], p = 0.009) and 18.32 (95% CI [3.95, 84.88], p < 0.001), respectively. Single visual assessment of abnormal locoregional lymph nodes predicted the presence of VGEI with a sensitivity of 35%, specificity of 96%, PPV of 95%, and NPV of 41%. The visual assessment of abnormal lymph nodes after qualitative assessment of 18F-FDG uptake intensity and pattern at the vascular graft location did not independently predict the presence of VGEI by logistic regression (Χ2: 3.60, p = 0.058; OR: 8.25, 95% CI [0.74, 63.37], p = 0.096). In conclusion, detection of abnormal locoregional lymph nodes on 18F-FDG PET/CT has a high specificity (96%) and PPV (95%) for VGEI. However, it did not add to currently used 18F-FDG PET/CT interpretation criteria.

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A systematic review and meta-analysis of 18F-fluoro-d-deoxyglucose positron emission tomography interpretation methods in vascular graft and endograft infection

Cited by 29 publications

References 35 publications

Contemporary Review of Multi-Modality Cardiac Imaging Evaluation of Infective Endocarditis

Contemporary Review of Multi-Modality Cardiac Imaging Evaluation of Infective Endocarditis

Infection of Vascular Prostheses: A Comprehensive Review

Added Value of Abnormal Lymph Nodes Detected with FDG-PET/CT in Suspected Vascular Graft Infection

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