A systematic review and meta-analysis of studies comparing burden from lung cancer and chronic obstructive pulmonary disease

Abstract

Background: Chronic obstructive pulmonary disease and lung cancer are both life-limiting diseases that confer burden in the form of symptoms and affect functioning and quality of life. Comparing burden between these diseases is of interest to determine whether people with chronic obstructive pulmonary disease require improved access to Specialist Palliative Care. Access should be based on needs rather than diagnosis or prognosis but is limited for people with chronic obstructive pulmonary disease compared to lung cancer. Aim: The aim of this study was to synthesise research comparing burden from chronic obstructive pulmonary disease and lung cancer to estimate relative need for Specialist Palliative Care. Design: A systematic review was conducted of observational quantitative studies published in English peer-reviewed journals comparing burden from chronic obstructive pulmonary disease and lung cancer (PROSPERO CRD42018108819). No limits were placed on disease stage. Meta-analyses were performed where studies used the same measure; otherwise, synthesis used a narrative approach. Risk of bias was assessed using the Agency for Healthcare Research and Quality tool. Data sources: Electronic databases were searched in September 2019. Results: Of 790 articles returned, 13 were included, reporting 11 studies. Risk of bias was generally moderate. Except for pain, burden tended to be at least as substantial from chronic obstructive pulmonary disease as from lung cancer, with breathlessness and impacts on functioning being significantly worse. Longitudinal studies suggest that people with chronic obstructive pulmonary disease live with burden for longer. Conclusion: Efforts should be made to ensure that access to Specialist Palliative Care is commensurate with chronic obstructive pulmonary disease’s substantial and long-lasting burden. Future research should clarify whether managing burden in chronic obstructive pulmonary disease and lung cancer requires different approaches.

Effect of Respiration Training-Assisted Western Medicine Therapy on Activity Tolerance, Pulmonary Function, and Quality of Life of Chronic Obstructive Pulmonary Disease Patients in the Stable Phase

“…Its pathogenic factors are smoking, air pollution, inhalation of dust and harmful gases, and respiratory tract infection. The disease is clinically distinguished by persistent respiratory symptoms and airflow limitation [ 2 ], severely affecting patients' life safety and at the same time causing a heavy economic burden on patients and their families. With the continuously deepened clinical research in recent years, attention has been paid to respiratory training in clinical work for patients with stable COPD [ 3 , 4 ].…”

Stability of distinct symptom experiences in patients with chronic obstructive pulmonary disease (COPD)

“…However, findings from our research group suggest that COPD patients report variations in their symptom burden based on their stage of disease [13]. In addition, research suggests COPD patients in a terminal stage of disease may experience a higher symptom burden compared to cancer patients, possibly because COPD patients often live longer with their disease burden [41,42]. Prolonged shortness of breath has previously been associated with symptoms such as fatigue, sleep disturbance, depression, anxiety, pain, and a higher number of comorbidities, as well as being a significant predictor of mortality in COPD [43][44][45].…”

COPD: Bei älteren Patienten an Sarkopenie denken und diese in ein therapeutisches Gesamtkonzept integrieren

“…Sie ist gekennzeichnet durch eine progrediente und irreversible Bronchialobstruktion. Die COPD betrifft etwa 20% der älteren Menschen und ist von erheblicher Relevanz, da sie mit Morbidität, Mortalität, Abhängigkeit und Pflegebedürftigkeit assoziiert ist [2].…”