A Systematic Review And Meta-Analysis: Botulinum Toxin A Effect on Postoperative Facial Scar Prevention

Yue, Shuai; Ju, Mengran; Su, Zhe

doi:10.1007/s00266-021-02596-7

Cited by 11 publications

(9 citation statements)

References 55 publications

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“…Furthermore, in comparison to regular botox applications, cosmetic products with botox-like effects are topically applied, and no needles are necessary to obtain the cosmetic effect. And, comparing again the biological effects of these two products, the injected botox targets muscle cells, or even neuralmuscular interface, which can promote undesirable effects for longer periods, since these tissues regenerate slowly in comparison to dermal structures 29 . Within this context, some initiatives like the WASP-PEP have already been proposed in the literature.…”

Section: Fibroblast Relaxationmentioning

confidence: 99%

Development of a new bioinspired peptide with fibroblast relaxation proprieties for cosmetics applications

Mortari

Ramalho

Camargo³

et al. 2023

Preprint

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The cosmetic field is driven by the development of new inputs and raw materials that are used to the development innovative products for consumers. Among the different sub-areas in cosmetology, skin care is the biggest area, with almost fifty percent of the market, and probably the most innovative of them. Thus, there is a complex value chain organized to develop and produce innovative inputs to supply the demands of the market. Within this context, different basic scientific areas, such as biochemistry and biotechnology, have been a source of inspiration for new active ingredients. In the present article, we will present the pre-clinical and clinical trials involved in the development of a new innovative biomimetic peptide derived from natural wasp venoms content. This new peptide sequence, here named WASP-PEP was designed based on natural peptide templates with some strategic amino acid modifications to increase the molecule's effectiveness. As the main results, we observed that the WASP-PEP is a biocompatible and dermatology tolerate compound, and the peptide can promote some relaxation effects in dermal fibroblasts. This relaxation effect is compatible with a kind of regulated and cumulative botox-like effect. Notablyr, this relaxation effect was also observed in the clinical trial, when volunteer subjects reported that their facial skin was flatter after the use of the WASP-PEP product for one month.

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Section: Fibroblast Relaxationmentioning

confidence: 99%

Development of a new bioinspired peptide with fibroblast relaxation proprieties for cosmetics applications

Mortari

Ramalho

Camargo³

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…However, the usage of BTA has not been considered a conventional therapy for scar management. The injection protocol of BTA is varied among studies ( 129 ). A consensus on the injection time and BTA concentration are required before widespread clinical practice and further investigation.…”

Section: Clinical and Potential Biological Strategies For Hts Prevent...mentioning

confidence: 99%

Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring

et al. 2022

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Hypertrophic scarring (HTS) is a major source of morbidity after cutaneous injury. Recent studies indicate that mechanical force significantly impacts wound healing and skin regeneration which opens up a new direction to combat scarring. Hence, a thorough understanding of the underlying mechanisms is essential in the development of efficacious scar therapeutics. This review provides an overview of the current understanding of the mechanotransduction signaling pathways in scar formation and some strategies that offload mechanical forces in the wounded region for scar prevention and treatment.

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“…In the last decade, researchers have published several scientific articles assessing the possibilities of using botulinum toxin type A (BTA) to prevent pathological scarring. [1][2][3][4][5][6] However, these data presented in a few clinical studies performed with insufficient power to form reasoned judgments. Therefore, to find an answer to the question about the possibility of using BTA to prevent hypertrophic and keloid scars, it is advisable to conduct a special study in the metaanalysis format.…”

Section: Introductionmentioning

confidence: 99%

Prospects for Use of Botulinum Toxin Type A for Prevention of Hypertrophic and Keloid Scars after Surgeries (Meta-analysis)

Korableva,

Romanenkov,

Kremlev

et al. 2024

Indian J Plast Surg

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Objective To evaluate the possibility of improving and preventing the formation of postoperative hypertrophic and keloid scars using botulinum toxin type A (BTA). Materials and Methods Scientific articles published in English have been systematically screened in PubMed/MEDLINE database over the entire period. The following information about the studies was analyzed: first author surname; year of publication; number of patients; average age; scar location; dosage of the drug administered; follow-up duration; scar assessment methods; results, incidence of hypertrophic and keloid scars formation. The odds ratio and 95% confidence interval were calculated for each of the estimated parameters. The statistical heterogeneity of publications assessed using the criteria of chi-square test and I 2. The differences were considered significant at p < 0.05. Results A total of 18 prospective randomized studies were selected for evaluation, containing data on the use of BTA in 363 cases. Patients receiving botulinum toxin had a lower Vancouver scar scale index, higher visual analog scale index, and higher Stony Brook scar evaluation scale score. The use of BTA reduces the risk of perceptible scar formation, the incidence of hypertrophic and keloid scars. Conclusion The use of BTA to obtain imperceptible scar and prevent hypertrophic and keloid postoperative scars demonstrates good prospects. However, there is no consensus regarding the pathophysiological mechanisms underlying the positive effect of BTA on the prevention of hypertrophic and keloid scars.

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A Systematic Review And Meta-Analysis: Botulinum Toxin A Effect on Postoperative Facial Scar Prevention

Cited by 11 publications

References 55 publications

Development of a new bioinspired peptide with fibroblast relaxation proprieties for cosmetics applications

Development of a new bioinspired peptide with fibroblast relaxation proprieties for cosmetics applications

Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring

Prospects for Use of Botulinum Toxin Type A for Prevention of Hypertrophic and Keloid Scars after Surgeries (Meta-analysis)

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