A systematic review and meta-analysis of the relationship between lipoprotein lipase Asn291Ser variant and diseases

Hu, Yongbin; Liu, Wei; Huang, Rong; Zhang, Xiaoying

doi:10.1194/jlr.m600108-jlr200

Cited by 50 publications

(32 citation statements)

References 46 publications

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“…Similar to the findings of Bhanushali & Das [34] in South Indians, the N291S polymorphism was not detected in our study, although this variant has been reported to be associated with dyslipidemia, DM and coronary artery disease in a meta-analysis [35].…”

Section: Discussionsupporting

confidence: 78%

Are Common Polymorphisms of the Lipoprotein Lipase and Human Paraoxonase-1 Genes Associated with the Metabolic Syndrome in South African Asian Indians?

Prakaschandra¹,

Gordon²,

Naidoo

2016

J Clin Exp Cardiolog

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A cross-sectional study was performed to determine the possible contribution of the Human Paraoxonase-1 (PON1) and Lipoprotein Lipase (LPL) polymorphisms to the risk of the metabolic syndrome (MetS) in 817 participants of South African Asian Indian ancestry. Demographic and anthropometric data, including fasting blood for analysis of glycaemic and lipid parameters was collected. DNA was isolated from peripheral blood and allelic polymorphisms at positions Q192R, L55M in the PON1 gene and S447X and N291S in the LPL gene were studied using real-time PCR. Melting curve analysis was used to identify homozygotes and heterozygotes. The MetS was classified using the harmonised criteria.The prevalence of the MetS was 47.99%, with the main drivers being the increased waist circumference (96.6%), raised blood pressure (76.8%) and raised triglyceride levels (72.4%). There was no significant difference (p=n/s) in the distribution of the genotypes as well as their alleles in subjects with and without MetS. Increased levels of triglycerides was found in subjects with the MetS who had the QQ (p=0.007; OR=1.19; 95%CI=1.04; 1.36) and QR (p=0.018; OR=1.73; 95% CI=1.12; 2.67) genotypes of the Q192R polymorphisms. Subjects who had both the SX genotype (S447X polymorphism) and the LM genotype (L55M polymorphism) were more likely to have the MetS than those without (p=0.016; OR 2.19; 95% CI: 1.17, 4.06). Interactions involving the PON 1 gene may predispose to the MetS and to its component risk factors such as hypertriglyceridemia in this population. Environmental factors, such as lifestyle behaviour patterns appear to be the main driver contributing to obesity-related MetS.

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Section: Discussionsupporting

confidence: 78%

Are Common Polymorphisms of the Lipoprotein Lipase and Human Paraoxonase-1 Genes Associated with the Metabolic Syndrome in South African Asian Indians?

Prakaschandra¹,

Gordon²,

Naidoo

2016

J Clin Exp Cardiolog

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“…Using a stringent threshold for statistical significance but without considering biological information may falsely reject an important biological finding. Since the associations observed in the 10 genes had been reported previously in the white and black populations [3,5,6,27,[31][32][33][34][35][36], our findings were less likely to be false positive.…”

Section: Discussionmentioning

confidence: 76%

Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics

Liao

Lin

Rundek

et al. 2008

Clinical Biochemistry

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Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. Design and methods:A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high-and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC). Results:We identified 19 SNPs at 10 genes that were significantly related to lipids (p<0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively. Conclusions:The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.

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“…However, Hallman et al (10) did not find any association between the HindIII(-) allele and higher LPL activity. The associations of certain polymorphic loci in the LPL promoter, introns or exons with lipid disorders and coronary artery disease (CAD) have been reported by some groups (rs285, rs1800590, rs320, rs268, rs1801177) (6)(7)(8)(11)(12)(13)(14) but contested by other authors (15)(16)(17). To the best of our knowledge, no data on the screening of such specific polymorphisms in the Saudi population have been reported.…”

Section: Introductionmentioning

confidence: 83%

Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease

et al. 2013

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Abstract. Lipoprotein lipase (LPL) plays a central role in lipoprotein metabolism by hydrolyzing the core triglycerides (TGs) of circulating chylomicrons and very-low-density lipoprotein (VLDL). The effects of LPL polymorphisms on lipid levels and coronary artery disease (CAD) have been inconsistent among studies and populations. To assess the lipid profiles and distributions of three LPL gene polymorphisms in Saudi patients with CAD, the HindIII, PvuII and Ser447Ter polymorphisms in the LPL gene were analyzed in 226 patients with CAD and 110 controls. Polymerase chain reaction-restriction fragment length polymorphism was used to detect LPL gene polymorphisms. The plasma lipid profiles of the patients were determined using standard enzymatic methods. Patients in the CAD group had significantly higher triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels than controls irrespective of the HindIII, PvuII or Ser447Ter genotype. Compared to the findings in controls, the HindIII TT, PvuII TC and Ser447Ter CC genotypes were associated with significantly reduced high-density lipoprotein cholesterol (HDL-C) levels in patients with CAD (P<0.0001). In summary, there are associations between LPL gene variants and high plasma TG, TC and LDL-C levels as well as low HDL-C levels.

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A systematic review and meta-analysis of the relationship between lipoprotein lipase Asn291Ser variant and diseases

Cited by 50 publications

References 46 publications

Are Common Polymorphisms of the Lipoprotein Lipase and Human Paraoxonase-1 Genes Associated with the Metabolic Syndrome in South African Asian Indians?

Are Common Polymorphisms of the Lipoprotein Lipase and Human Paraoxonase-1 Genes Associated with the Metabolic Syndrome in South African Asian Indians?

Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics

Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease

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