A systematic review and meta-analysis of the clinicopathologic characteristics of cystic versus solid pancreatic neuroendocrine neoplasms

Are Cystic Pancreatic Neuroendocrine Tumors an Indolent Entity Results from a Single-Center Surgical Series

“…Moreover, a recent systematic review and meta-analysis extracted pooled data from published series and reinforced this evidence claimPaiella et al ing that the dimensional threshold for the conservative management of CPanNETs could be even higher than that used for SPanNETs [14]. We did not find any significant difference in terms of both overall and diseasespecific survival estimates between the group of CPanNETs and a matched cohort of solid counterparts.…”

“…As a matter of fact, there is scarcity of data with regard to actual differences in terms of epidemiology, biology, and long-term outcomes following surgical resection between cystic and solid pancreatic neuroendocrine tumors (SPanNETs) [5][6][7]11]. Although several surgical series report that CPanNETs can sometimes harbor malignancy [5,9,11,13], a recent metaanalysis claimed that, due to their mostly benign biology, parenchyma-sparing pancreatic resections can be advocated as the treatment of choice of CPanNETs [14].…”

Laparoscopic splenopancreatectomy for an endocrine tumor with cystic changes: a case report

“…However, as reported by Singhi et al , lymph node and distant metastases are less common in CPEN cases than in PEN cases, as are nerve plexus permeation and vascular invasion. Moreover, CPENs have a low potential for biological malignancy and, according to many reports, a better prognosis than PENs . Accordingly, limited surgery such as distal pancreatectomy without splenectomy and enucleation should be considered for CPENs that are not accompanied preoperatively by lymph node or distant metastasis, as was seen in the present case.…”

Neuroendokrynne torbielowate nowotwory trzustki — punkt widzenia gastroenterologa

“…Most pancreatic cysts are either non-neoplastic lesions, like pseudocysts, or tumors with low (SCA), intermediate (IPMN-BD -branch duct intrapappilary mucinous neoplasma or higher potential of malignant transformation (MCN -mucinous cystic neoplasma, IPMN-MD -main duct intrapappilary mucinous) neoplasms, SPN -solid pappilary neoplasms). Pancreatic neuroendocrine tumours (PNEN) constitute about 5% of all pancreatic neoplasm with increasing incidence of 0.32/100,000/year [7,14]; among these, cystic lesions represent from 13 to 17% of all PNENs [15][16][17]. In the study by Bordeianou et.…”

“…It is a matter of a debate whether the CPENs represent just a variant of solid tumour or a different entity. It is suspected that they appear as a result of haemorrhage, necrosis, disturbances of the blood supply caused by the tumour capsule, intraductal growth, or cystic degeneration of solid PNENs [17,22]. However, there are a lot of clinical differences between solid and cystic neuroendocrine tumours [16].…”