A Systematic Review and Meta-Analysis on the Association between Hypertension and Tinnitus

Abstract

Hypertension has been suggested to be one possible risk factor of tinnitus, but the association between hypertension and tinnitus remains uncertain. The authors performed a meta-analysis of the existing studies on the association between hypertension and tinnitus. We performed literature search of studies using SinoMed, CNKI, WanFang, PubMed, Scopus, Web of Science, and Google Scholar. Studies reported the odds ratio and 95% confidence interval (CI) (or provided sufficient information for calculation) of the association between hypertension and tinnitus were included. A total of 19 eligible studies with 20 effect estimates were used in this study. They included 63,154 participants with age ranging from 14 to 92. The pooled OR, which was pooled using a random effects model, was 1.37 (95% CI: 1.16 to 1.62). There was no evidence of publication bias (p = 0.11 for Begg's test, p = 0.96 for Egger's test). By meta-regression, we found that study design may be one possible factor of heterogeneity. Sensitivity analysis found that the result was stable. This study suggests that hypertension might be one risk factor of tinnitus, and hypertension prevention and control might be helpful in preventing tinnitus.

Tinnitus and its risk factors in african americans: The Jackson Heart Study

“…A metaanalysis performed in 2015 of 19 studies showed a significant association between hypertension and tinnitus. 10 Yet, other studies report an association between hypotension and worsening congestive heart failure and tinnitus. 11,12 One study reported an association between nighttime blood pressure and tinnitus.…”

“…Cardiometabolic factors have also been associated with tinnitus. A meta‐analysis performed in 2015 of 19 studies showed a significant association between hypertension and tinnitus . Yet, other studies report an association between hypotension and worsening congestive heart failure and tinnitus .…”

“…One study reported an association between nighttime blood pressure and tinnitus . In addition, stress, decreased sleep, hyperlipidemia, osteoarthritis, rheumatoid arthritis, asthma, diabetes, thyroid disease, hypertension, increased body mass index (BMI), increased neck circumference, anxiety, and depression have been shown to be associated with increased reported tinnitus …”

“…13 In addition, stress, decreased sleep, hyperlipidemia, osteoarthritis, rheumatoid arthritis, asthma, diabetes, thyroid disease, hypertension, increased body mass index (BMI), increased neck circumference, anxiety, and depression have been shown to be associated with increased reported tinnitus. 4,10,[14][15][16] African Americans present an intriguing paradox, where epidemiological studies show higher prevalence of cardiometabolic disease and associated risk factors, but they show lower prevalence of hearing loss and tinnitus compared to other race/ethnicity groups. 4,8,9 Interestingly, African Americans with cardiometabolic disease are more likely to report depression, which may further influence tinnitus report and handicap.…”

Outcomes of Triple-Combination Therapy for Chronic Tinnitus

“…Informed consent was obtained from the patient for the publication of this image. rheumatoid arthritis, asthma, depression, thyroid disease, an abnormal tympanic membrane, and increased noise exposure (3,(15)(16)(17)(18). Hyperinsulinemia (17,19), drug abuse in boys and exposure to second hand smoke in girls (20), obesity, and diabetes mellitus (17), have also been identified as risk factors of tinnitus.…”