A systematic overexpression approach reveals native targets to increase squalene production in Synechocystis sp. PCC 6803
Anna T. Germann,
Andreas Nakielski,
Maximilian Dietsch
et al.
Abstract:Cyanobacteria are a promising platform for the production of the triterpene squalene (C30), a precursor for all plant and animal sterols, and a highly attractive intermediate towards triterpenoids, a large group of secondary plant metabolites. Synechocystis sp. PCC 6803 natively produces squalene from CO2 through the MEP pathway. Based on the predictions of a constraint-based metabolic model, we took a systematic overexpression approach to quantify native Synechocystis gene’s impact on squalene production in a… Show more
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