A systematic literature review on the clinical efficacy of low dose naltrexone and its effect on putative pathophysiological mechanisms among patients diagnosed with fibromyalgia

Partridge, Sarah; Quadt, Lisa; Bolton, Monica; Eccles, Jessica; Thompson, Charlotte; Colasanti, Alessandro; Bremner, Stephen; Jones, Christopher I.; Bruun, Karin Due; Marwijk, Harm van

doi:10.1016/j.heliyon.2023.e15638

Cited by 4 publications

(1 citation statement)

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“…The immunomodulatory effects of LDN have been hypothesized to provide benefits for patients with fibromyalgia, which represents a neuroinflammatory condition characterized by widespread musculoskeletal pain associated with sleep, memory, and mood issues. There is some evidence indicating that LDN can provide pain relief and improve quality of life in patients [ 40 ]. In one early study on LDN in fibromyalgia, LDN was found to mediate a modest reduction (~30%) in symptoms of pain, fatigue, and stress based on examination of the erythrocyte sedimentation rate as the primary marker for these conclusions [ 20 , 41 ].…”

Section: Therapeutic Potential Of Ldn In the Treatment Of Non-arthrit...mentioning

confidence: 99%

Opiate Antagonists for Chronic Pain: A Review on the Benefits of Low-Dose Naltrexone in Arthritis versus Non-Arthritic Diseases

et al. 2023

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Chronic pain conditions create major financial and emotional burdens that can be devastating for individuals and society. One primary source of pain is arthritis, a common inflammatory disease of the joints that causes persistent pain in affected people. The main objective of pharmacological treatments for either rheumatoid arthritis (RA) or osteoarthritis (OA) is to reduce pain. Non-steroidal anti-inflammatory drugs, opioids, and opioid antagonists have each been considered in the management of chronic pain in arthritis patients. Naltrexone is an oral-activated opioid antagonist with biphasic dose-dependent pharmacodynamic effects. The molecule acts as a competitive inhibitor of opioid receptors at high doses. However, naltrexone at low doses has been shown to have hormetic effects and provides relief for chronic pain conditions such as fibromyalgia, multiple sclerosis (MS), and inflammatory bowel disorders. Current knowledge of naltrexone suggests that low-dose treatments may be effective in the treatment of pain perception in chronic inflammatory conditions observed in patients with either RA or OA. In this review, we evaluated the therapeutic benefits of low-dose naltrexone (LDN) on arthritis-related pain conditions.

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Section: Therapeutic Potential Of Ldn In the Treatment Of Non-arthrit...mentioning

confidence: 99%